FSHB_HUMAN
ID FSHB_HUMAN Reviewed; 129 AA.
AC P01225; A2TF08; A5JVV3; Q14D61;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1989, sequence version 2.
DT 03-AUG-2022, entry version 213.
DE RecName: Full=Follitropin subunit beta;
DE AltName: Full=Follicle-stimulating hormone beta subunit;
DE Short=FSH-B;
DE Short=FSH-beta;
DE AltName: Full=Follitropin beta chain;
DE Flags: Precursor;
GN Name=FSHB;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2885163; DOI=10.1089/dna.1987.6.205;
RA Watkins P.C., Eddy R., Beck A.K., Vellucci V., Leverone B., Tanzi R.E.,
RA Gusella J.F., Shows T.B.;
RT "DNA sequence and regional assignment of the human follicle-stimulating
RT hormone beta-subunit gene to the short arm of human chromosome 11.";
RL DNA 6:205-212(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, AND
RP SUBUNIT.
RX PubMed=2494176; DOI=10.1016/s0021-9258(18)83656-0;
RA Keene J.L., Matzuk M.M., Otani T., Fauser B.C.J.M., Galway A.B.,
RA Hsueh A.J.W., Boime I.;
RT "Expression of biologically active human follitropin in Chinese hamster
RT ovary cells.";
RL J. Biol. Chem. 264:4769-4775(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3139991; DOI=10.1210/mend-2-9-806;
RA Jameson J.L., Becker C.B., Lindell C.M., Habener J.F.;
RT "Human follicle-stimulating hormone beta-subunit gene encodes multiple
RT messenger ribonucleic acids.";
RL Mol. Endocrinol. 2:806-815(1988).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Akbari Eidgahi M.R., Shaebani A.A., Nasr R.;
RT "Follicle-stimulating hormone (FSHB) beta subunit genes.";
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP PROTEIN SEQUENCE OF 19-129.
RX PubMed=3151250; DOI=10.1007/bf01024882;
RA Shome B., Parlow A.F., Liu W.K., Nahm H.S., Wen T., Ward D.N.;
RT "A reevaluation of the amino acid sequence of human follitropin beta-
RT subunit.";
RL J. Protein Chem. 7:325-339(1988).
RN [9]
RP PRELIMINARY PROTEIN SEQUENCE OF 19-129.
RX PubMed=1249074; DOI=10.1016/s0021-9258(17)33791-2;
RA Saxena B.B., Rathnam P.;
RT "Amino acid sequence of the beta subunit of follicle-stimulating hormone
RT from human pituitary glands.";
RL J. Biol. Chem. 251:993-1005(1976).
RN [10]
RP PRELIMINARY PROTEIN SEQUENCE OF 19-129.
RX PubMed=4835136; DOI=10.1210/jcem-39-1-203;
RA Shome B., Parlow A.F.;
RT "Human follicle stimulating hormone: first proposal for the amino acid
RT sequence of the hormone-specific, beta subunit (hFSHb).";
RL J. Clin. Endocrinol. Metab. 39:203-205(1974).
RN [11]
RP FUNCTION.
RX PubMed=407105; DOI=10.1016/s0015-0282(16)42734-2;
RA Maroulis G.B., Parlow A.F., Marshall J.R.;
RT "Isolated follicle-stimulating hormone deficiency in man.";
RL Fertil. Steril. 28:818-822(1977).
RN [12]
RP PRELIMINARY ASSIGNMENT OF DISULFIDE BONDS.
RX PubMed=6774759; DOI=10.1016/0005-2795(80)90084-7;
RA Fujiki Y., Rathnam P., Saxena B.B.;
RT "Studies on the disulfide bonds in human pituitary follicle-stimulating
RT hormone.";
RL Biochim. Biophys. Acta 624:428-435(1980).
RN [13]
RP DISULFIDE BONDS.
RX PubMed=11501762; DOI=10.1515/bc.2001.120;
RA Amoresano A., Orru S., Siciliano R.A., De Luca E., Napoleoni R., Sirna A.,
RA Pucci P.;
RT "Assignment of the complete disulphide bridge pattern in the human
RT recombinant follitropin beta-chain.";
RL Biol. Chem. 382:961-968(2001).
RN [14]
RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF MUTANT ALA-27.
RX PubMed=11222739; DOI=10.1210/mend.15.3.0603;
RA Fox K.M., Dias J.A., Van Roey P.;
RT "Three-dimensional structure of human follicle-stimulating hormone.";
RL Mol. Endocrinol. 15:378-389(2001).
RN [15]
RP X-RAY CRYSTALLOGRAPHY (2.92 ANGSTROMS) OF 19-129 IN COMPLEX WITH CGA AND
RP FSHR, DISULFIDE BONDS, AND GLYCOSYLATION AT ASN-25 AND ASN-42.
RX PubMed=15662415; DOI=10.1038/nature03206;
RA Fan Q.R., Hendrickson W.A.;
RT "Structure of human follicle-stimulating hormone in complex with its
RT receptor.";
RL Nature 433:269-277(2005).
RN [16] {ECO:0007744|PDB:4MQW}
RP X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 19-129 IN COMPLEX WITH CGA AND
RP FSHR, GLYCOSYLATION AT ASN-25 AND ASN-42, FUNCTION, SUBUNIT, DISULFIDE
RP BONDS, AND MUTAGENESIS OF THR-78.
RX PubMed=24692546; DOI=10.1074/jbc.m114.549592;
RA Jiang X., Fischer D., Chen X., McKenna S.D., Liu H., Sriraman V., Yu H.N.,
RA Goutopoulos A., Arkinstall S., He X.;
RT "Evidence for follicle-stimulating hormone receptor as a functional
RT trimer.";
RL J. Biol. Chem. 289:14273-14282(2014).
RN [17]
RP INVOLVEMENT IN HH24, AND FUNCTION.
RX PubMed=8220432; DOI=10.1038/ng0993-83;
RA Matthews C.H., Borgato S., Beck-Peccoz P., Adams M., Tone Y., Gambino G.,
RA Casagrande S., Tedeschini G., Benedetti A., Chatterjee V.K.K.;
RT "Primary amenorrhoea and infertility due to a mutation in the beta-subunit
RT of follicle-stimulating hormone.";
RL Nat. Genet. 5:83-86(1993).
RN [18]
RP VARIANT HH24 GLY-69.
RX PubMed=9271483; DOI=10.1056/nejm199708283370905;
RA Layman L.C., Lee E.-J., Peak D.B., Namnoum A.B., Vu K.V., van Lingen B.L.,
RA Gray M.R., McDonough P.G., Reindollar R.H., Jameson J.L.;
RT "Delayed puberty and hypogonadism caused by mutations in the follicle-
RT stimulating hormone beta-subunit gene.";
RL N. Engl. J. Med. 337:607-611(1997).
RN [19]
RP INVOLVEMENT IN HH24.
RX PubMed=9280841; DOI=10.1056/nejm199708283370918;
RA Matthews C., Chatterjee V.K.;
RT "Isolated deficiency of follicle-stimulating hormone re-revisited.";
RL N. Engl. J. Med. 337:642-642(1997).
RN [20]
RP VARIANT ILE-20.
RX PubMed=10391209; DOI=10.1038/10290;
RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,
RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,
RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,
RA Lander E.S.;
RT "Characterization of single-nucleotide polymorphisms in coding regions of
RT human genes.";
RL Nat. Genet. 22:231-238(1999).
RN [21]
RP ERRATUM OF PUBMED:10391209.
RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,
RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,
RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,
RA Lander E.S.;
RL Nat. Genet. 23:373-373(1999).
CC -!- FUNCTION: Together with the alpha chain CGA constitutes follitropin,
CC the follicle-stimulating hormone, and provides its biological
CC specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled
CC receptor, on target cells to activate downstream signaling pathways
CC (PubMed:2494176, PubMed:24692546). Follitropin is involved in follicle
CC development and spermatogenesis in reproductive organs (PubMed:407105,
CC PubMed:8220432). {ECO:0000269|PubMed:24692546,
CC ECO:0000269|PubMed:2494176, ECO:0000269|PubMed:407105,
CC ECO:0000269|PubMed:8220432}.
CC -!- SUBUNIT: Heterodimer. The active follitropin is a heterodimer composed
CC of an alpha chain/CGA shared with other hormones and a unique beta
CC chain/FSHB shown here. {ECO:0000269|PubMed:15662415,
CC ECO:0000269|PubMed:24692546, ECO:0000269|PubMed:2494176}.
CC -!- INTERACTION:
CC P01225; P01215: CGA; NbExp=4; IntAct=EBI-1030645, EBI-718913;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2494176}.
CC Note=Efficient secretion requires dimerization with CGA.
CC {ECO:0000269|PubMed:2494176}.
CC -!- DISEASE: Hypogonadotropic hypogonadism 24 with or without anosmia
CC (HH24) [MIM:229070]: A form of hypogonadotropic hypogonadism, a group
CC of disorders characterized by absent or incomplete sexual maturation by
CC the age of 18 years, in conjunction with low levels of circulating
CC gonadotropins and testosterone and no other abnormalities of the
CC hypothalamic-pituitary axis. HH24 is characterized by primary
CC amenorrhea in women, oligo or azoospermia with low to normal
CC testosterone levels in men, and infertility.
CC {ECO:0000269|PubMed:8220432, ECO:0000269|PubMed:9271483,
CC ECO:0000269|PubMed:9280841}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- PHARMACEUTICAL: Available under the names Gonal-F or Metrodin HP
CC (Serono) and Puregon (Organon). Used in the treatment of infertility in
CC women with proven hypopituitarism or who have not responded to
CC clomifene; or in superovulation treatment for assisted conception (such
CC as in vitro fertilization). Metrodin HP is also used in the treatment
CC of hypogonadotrophic hypogonadism in men for the stimulation of
CC spermatogenesis.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Wikipedia; Note=Follicle-stimulating hormone entry;
CC URL="https://en.wikipedia.org/wiki/Follicle_stimulating_hormone";
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DR EMBL; M16647; AAA52476.1; -; Genomic_DNA.
DR EMBL; M16646; AAA52476.1; JOINED; Genomic_DNA.
DR EMBL; M24540; AAA52470.1; -; Genomic_DNA.
DR EMBL; M24539; AAA52470.1; JOINED; Genomic_DNA.
DR EMBL; M54914; AAB02868.1; -; Genomic_DNA.
DR EMBL; M54913; AAB02868.1; JOINED; Genomic_DNA.
DR EMBL; EF198021; ABM88373.1; -; Genomic_DNA.
DR EMBL; EF585489; ABQ57401.1; -; mRNA.
DR EMBL; EF585490; ABQ57402.1; -; Genomic_DNA.
DR EMBL; EU081884; ABU96749.1; -; Genomic_DNA.
DR EMBL; EU081885; ABU96750.1; -; Genomic_DNA.
DR EMBL; AL358944; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471064; EAW68260.1; -; Genomic_DNA.
DR EMBL; BC113488; AAI13489.1; -; mRNA.
DR EMBL; BC113490; AAI13491.1; -; mRNA.
DR CCDS; CCDS7868.1; -.
DR PIR; A40920; FTHUB.
DR RefSeq; NP_000501.1; NM_000510.2.
DR RefSeq; NP_001018090.1; NM_001018080.1.
DR PDB; 1FL7; X-ray; 3.00 A; B/D=19-129.
DR PDB; 1XWD; X-ray; 2.92 A; B/E=19-129.
DR PDB; 4AY9; X-ray; 2.50 A; B/E/H=19-129.
DR PDB; 4MQW; X-ray; 2.90 A; B/E/H=19-129.
DR PDBsum; 1FL7; -.
DR PDBsum; 1XWD; -.
DR PDBsum; 4AY9; -.
DR PDBsum; 4MQW; -.
DR AlphaFoldDB; P01225; -.
DR SMR; P01225; -.
DR BioGRID; 108766; 1.
DR ComplexPortal; CPX-665; Follicle-stimulating hormone complex.
DR DIP; DIP-35604N; -.
DR ELM; P01225; -.
DR IntAct; P01225; 3.
DR STRING; 9606.ENSP00000416606; -.
DR GlyConnect; 165; 10 N-Linked glycans.
DR GlyGen; P01225; 3 sites, 28 N-linked glycans (3 sites).
DR iPTMnet; P01225; -.
DR PhosphoSitePlus; P01225; -.
DR SwissPalm; P01225; -.
DR BioMuta; FSHB; -.
DR DMDM; 120552; -.
DR MassIVE; P01225; -.
DR PaxDb; P01225; -.
DR PeptideAtlas; P01225; -.
DR PRIDE; P01225; -.
DR Antibodypedia; 12775; 995 antibodies from 38 providers.
DR DNASU; 2488; -.
DR Ensembl; ENST00000254122.8; ENSP00000254122.3; ENSG00000131808.11.
DR Ensembl; ENST00000417547.1; ENSP00000416606.1; ENSG00000131808.11.
DR Ensembl; ENST00000533718.2; ENSP00000433424.1; ENSG00000131808.11.
DR GeneID; 2488; -.
DR KEGG; hsa:2488; -.
DR MANE-Select; ENST00000533718.2; ENSP00000433424.1; NM_001382289.1; NP_001369218.1.
DR UCSC; uc001msl.4; human.
DR CTD; 2488; -.
DR DisGeNET; 2488; -.
DR GeneCards; FSHB; -.
DR HGNC; HGNC:3964; FSHB.
DR HPA; ENSG00000131808; Tissue enriched (pituitary).
DR MalaCards; FSHB; -.
DR MIM; 136530; gene.
DR MIM; 229070; phenotype.
DR neXtProt; NX_P01225; -.
DR OpenTargets; ENSG00000131808; -.
DR Orphanet; 52901; Isolated follicle stimulating hormone deficiency.
DR PharmGKB; PA28382; -.
DR VEuPathDB; HostDB:ENSG00000131808; -.
DR eggNOG; ENOG502S39C; Eukaryota.
DR GeneTree; ENSGT00940000160051; -.
DR HOGENOM; CLU_126319_3_0_1; -.
DR InParanoid; P01225; -.
DR OMA; LCWKAIC; -.
DR OrthoDB; 1362225at2759; -.
DR PhylomeDB; P01225; -.
DR TreeFam; TF332940; -.
DR PathwayCommons; P01225; -.
DR Reactome; R-HSA-209822; Glycoprotein hormones.
DR Reactome; R-HSA-375281; Hormone ligand-binding receptors.
DR Reactome; R-HSA-418555; G alpha (s) signalling events.
DR Reactome; R-HSA-9660821; ADORA2B mediated anti-inflammatory cytokines production.
DR SABIO-RK; P01225; -.
DR SignaLink; P01225; -.
DR SIGNOR; P01225; -.
DR BioGRID-ORCS; 2488; 6 hits in 1061 CRISPR screens.
DR EvolutionaryTrace; P01225; -.
DR GeneWiki; FSHB; -.
DR GenomeRNAi; 2488; -.
DR Pharos; P01225; Tbio.
DR PRO; PR:P01225; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; P01225; protein.
DR Bgee; ENSG00000131808; Expressed in adenohypophysis and 45 other tissues.
DR ExpressionAtlas; P01225; baseline and differential.
DR Genevisible; P01225; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0016914; C:follicle-stimulating hormone complex; IDA:UniProtKB.
DR GO; GO:0016913; F:follicle-stimulating hormone activity; IDA:UniProtKB.
DR GO; GO:0007292; P:female gamete generation; TAS:ProtInc.
DR GO; GO:0007565; P:female pregnancy; TAS:ProtInc.
DR GO; GO:0042699; P:follicle-stimulating hormone signaling pathway; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:0045780; P:positive regulation of bone resorption; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; NAS:BHF-UCL.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; NAS:BHF-UCL.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0010893; P:positive regulation of steroid biosynthetic process; IDA:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; NAS:BHF-UCL.
DR GO; GO:0006701; P:progesterone biosynthetic process; TAS:BHF-UCL.
DR GO; GO:0045670; P:regulation of osteoclast differentiation; IEA:Ensembl.
DR GO; GO:0010469; P:regulation of signaling receptor activity; IDA:UniProtKB.
DR GO; GO:0060011; P:Sertoli cell proliferation; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEP:BHF-UCL.
DR CDD; cd00069; GHB_like; 1.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR001545; Gonadotropin_bsu.
DR InterPro; IPR018245; Gonadotropin_bsu_CS.
DR PANTHER; PTHR11515; PTHR11515; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR SMART; SM00068; GHB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Disease variant; Disulfide bond;
KW Glycoprotein; Hormone; Hypogonadotropic hypogonadism; Pharmaceutical;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000269|PubMed:3151250"
FT CHAIN 19..129
FT /note="Follitropin subunit beta"
FT /id="PRO_0000011711"
FT CARBOHYD 25
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:15662415,
FT ECO:0000269|PubMed:4835136, ECO:0007744|PDB:4MQW"
FT CARBOHYD 42
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:15662415,
FT ECO:0000269|PubMed:4835136, ECO:0007744|PDB:4MQW"
FT DISULFID 21..69
FT /evidence="ECO:0000269|PubMed:24692546,
FT ECO:0007744|PDB:4MQW"
FT DISULFID 35..84
FT /evidence="ECO:0000269|PubMed:24692546,
FT ECO:0007744|PDB:4MQW"
FT DISULFID 38..122
FT /evidence="ECO:0000269|PubMed:24692546,
FT ECO:0007744|PDB:4MQW"
FT DISULFID 46..100
FT /evidence="ECO:0000269|PubMed:24692546,
FT ECO:0007744|PDB:4MQW"
FT DISULFID 50..102
FT /evidence="ECO:0000269|PubMed:24692546,
FT ECO:0007744|PDB:4MQW"
FT DISULFID 105..112
FT /evidence="ECO:0000269|PubMed:24692546,
FT ECO:0007744|PDB:4MQW"
FT VARIANT 20
FT /note="S -> I (in dbSNP:rs6170)"
FT /evidence="ECO:0000269|PubMed:10391209"
FT /id="VAR_012047"
FT VARIANT 69
FT /note="C -> G (in HH24; dbSNP:rs5030776)"
FT /evidence="ECO:0000269|PubMed:9271483"
FT /id="VAR_033015"
FT MUTAGEN 78
FT /note="T->E: Increased activation of the follicle-
FT stimulating hormone signaling pathway."
FT /evidence="ECO:0000269|PubMed:24692546"
FT STRAND 21..32
FT /evidence="ECO:0007829|PDB:4AY9"
FT HELIX 33..35
FT /evidence="ECO:0007829|PDB:4AY9"
FT STRAND 37..53
FT /evidence="ECO:0007829|PDB:4AY9"
FT STRAND 68..81
FT /evidence="ECO:0007829|PDB:4AY9"
FT STRAND 85..87
FT /evidence="ECO:0007829|PDB:4MQW"
FT STRAND 90..103
FT /evidence="ECO:0007829|PDB:4AY9"
FT TURN 107..109
FT /evidence="ECO:0007829|PDB:4AY9"
FT STRAND 110..114
FT /evidence="ECO:0007829|PDB:4AY9"
SQ SEQUENCE 129 AA; 14700 MW; 9D2AF00DD76B8E2B CRC64;
MKTLQFFFLF CCWKAICCNS CELTNITIAI EKEECRFCIS INTTWCAGYC YTRDLVYKDP
ARPKIQKTCT FKELVYETVR VPGCAHHADS LYTYPVATQC HCGKCDSDST DCTVRGLGPS
YCSFGEMKE
