ID   ALDH_STRCO              Reviewed;         507 AA.
AC   Q9RJZ6;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Probable aldehyde dehydrogenase;
DE            EC=1.2.1.3;
GN   OrderedLocusNames=SCO1174; ORFNames=SCG11A.05;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC         Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.3;
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; AL939108; CAB61586.1; -; Genomic_DNA.
DR   RefSeq; NP_625464.1; NC_003888.3.
DR   RefSeq; WP_011027628.1; NZ_VNID01000006.1.
DR   AlphaFoldDB; Q9RJZ6; -.
DR   SMR; Q9RJZ6; -.
DR   STRING; 100226.SCO1174; -.
DR   GeneID; 1096597; -.
DR   KEGG; sco:SCO1174; -.
DR   PATRIC; fig|100226.15.peg.1172; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_0_2_11; -.
DR   InParanoid; Q9RJZ6; -.
DR   OMA; ILMGAWK; -.
DR   PhylomeDB; Q9RJZ6; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..507
FT                   /note="Probable aldehyde dehydrogenase"
FT                   /id="PRO_0000056464"
FT   ACT_SITE        263
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        302
FT                   /evidence="ECO:0000250"
FT   BINDING         219..225
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   507 AA;  55674 MW;  0110815B2D8F96DD CRC64;
     MTRYAAPGTE GAIVSYQSRY DHFIGGEYVP PARGQYFENP SPVNGLPFTE IARGTADDVE
     RALDAAHEAA PGWGRTSVTE RSDILLKIAD RMEANLERLA VAESWENGKP VRETLAADIP
     LAIDHFRYFA GAVRAQEGSL GEIDDDTVAY HFHEPLGVVA QIIPWNFPIL MATWKLAPAL
     AAGNAVVLKP AEQTPASIHY WLSLVADLLP PGVLNVVNGF GVEAGKPLAS SPRVAKVAFT
     GETTTGRLIM QYASENIKPV TLELGGKSPN IFFEDVWARD DDFRDKALEG FTMFALNQGE
     VCTCPSRALV QRGVYAEFME AAVARTELIK PGHPLDTDTM IGAQASNDQL EKILSYLDIG
     RQEGAKVLTG GERIEHDGEL KGGYYVQPTI FEGHNRMRIF QEEIFGPVVS VTSFDDFDDA
     VKTANDTLYG LGAGVWTRDM NTAYRAGRAI QAGRVWTNCY HAYPAHAAFG GYKQSGIGRE
     NHKMMLEHYQ QTKNILCSYS PKKLGFF