FSIP1_HUMAN
ID FSIP1_HUMAN Reviewed; 581 AA.
AC Q8NA03; Q6X2C8; Q86Y89;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Fibrous sheath-interacting protein 1;
GN Name=FSIP1; ORFNames=HSD10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RA Hu T.H., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.;
RT "A new spermatogenesis-related gene.";
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS HIS-354 AND
RP ARG-402.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the FSIP1 family. {ECO:0000305}.
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DR EMBL; AY260140; AAP20066.1; -; mRNA.
DR EMBL; AK093308; BAC04128.1; -; mRNA.
DR EMBL; CH471125; EAW92382.1; -; Genomic_DNA.
DR EMBL; BC045191; AAH45191.1; -; mRNA.
DR CCDS; CCDS10050.1; -.
DR RefSeq; NP_001311267.1; NM_001324338.1.
DR RefSeq; NP_689810.3; NM_152597.4.
DR RefSeq; XP_011519607.1; XM_011521305.2.
DR RefSeq; XP_011519608.1; XM_011521306.1.
DR AlphaFoldDB; Q8NA03; -.
DR SMR; Q8NA03; -.
DR BioGRID; 127805; 6.
DR IntAct; Q8NA03; 2.
DR STRING; 9606.ENSP00000280236; -.
DR iPTMnet; Q8NA03; -.
DR PhosphoSitePlus; Q8NA03; -.
DR BioMuta; FSIP1; -.
DR DMDM; 74729808; -.
DR EPD; Q8NA03; -.
DR MassIVE; Q8NA03; -.
DR MaxQB; Q8NA03; -.
DR PaxDb; Q8NA03; -.
DR PeptideAtlas; Q8NA03; -.
DR PRIDE; Q8NA03; -.
DR ProteomicsDB; 72621; -.
DR Antibodypedia; 52142; 229 antibodies from 20 providers.
DR DNASU; 161835; -.
DR Ensembl; ENST00000350221.4; ENSP00000280236.3; ENSG00000150667.8.
DR GeneID; 161835; -.
DR KEGG; hsa:161835; -.
DR MANE-Select; ENST00000350221.4; ENSP00000280236.3; NM_152597.5; NP_689810.3.
DR UCSC; uc001zki.4; human.
DR CTD; 161835; -.
DR DisGeNET; 161835; -.
DR GeneCards; FSIP1; -.
DR HGNC; HGNC:21674; FSIP1.
DR HPA; ENSG00000150667; Group enriched (intestine, testis).
DR MIM; 615795; gene.
DR neXtProt; NX_Q8NA03; -.
DR OpenTargets; ENSG00000150667; -.
DR PharmGKB; PA142671750; -.
DR VEuPathDB; HostDB:ENSG00000150667; -.
DR eggNOG; ENOG502RXFB; Eukaryota.
DR GeneTree; ENSGT00390000013879; -.
DR HOGENOM; CLU_031884_1_0_1; -.
DR InParanoid; Q8NA03; -.
DR OMA; PCKVETA; -.
DR OrthoDB; 608640at2759; -.
DR PhylomeDB; Q8NA03; -.
DR TreeFam; TF351151; -.
DR PathwayCommons; Q8NA03; -.
DR SignaLink; Q8NA03; -.
DR BioGRID-ORCS; 161835; 13 hits in 1069 CRISPR screens.
DR ChiTaRS; FSIP1; human.
DR GenomeRNAi; 161835; -.
DR Pharos; Q8NA03; Tbio.
DR PRO; PR:Q8NA03; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q8NA03; protein.
DR Bgee; ENSG00000150667; Expressed in mucosa of transverse colon and 101 other tissues.
DR ExpressionAtlas; Q8NA03; baseline and differential.
DR Genevisible; Q8NA03; HS.
DR InterPro; IPR026246; Fsip1.
DR PANTHER; PTHR22012; PTHR22012; 1.
DR Pfam; PF15554; FSIP1; 1.
DR PRINTS; PR02075; FIBSHEATHIP1.
PE 2: Evidence at transcript level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..581
FT /note="Fibrous sheath-interacting protein 1"
FT /id="PRO_0000314918"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 105..153
FT /evidence="ECO:0000255"
FT COMPBIAS 11..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..365
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..581
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 87
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q66H16"
FT VARIANT 64
FT /note="N -> D (in dbSNP:rs1166719)"
FT /id="VAR_038124"
FT VARIANT 354
FT /note="R -> H (in dbSNP:rs937961)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_038125"
FT VARIANT 374
FT /note="E -> G (in dbSNP:rs16969673)"
FT /id="VAR_038126"
FT VARIANT 402
FT /note="C -> R (in dbSNP:rs10152640)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_038127"
FT VARIANT 411
FT /note="L -> F (in dbSNP:rs12908846)"
FT /id="VAR_038128"
FT VARIANT 528
FT /note="G -> A (in dbSNP:rs16969386)"
FT /id="VAR_038129"
FT CONFLICT 75
FT /note="S -> R (in Ref. 1; AAP20066)"
FT /evidence="ECO:0000305"
FT CONFLICT 574
FT /note="A -> G (in Ref. 1; AAP20066)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 581 AA; 66121 MW; 979A8B4DE2177C74 CRC64;
MDIIKGNLDG ISKPASNSRI RPGSRSSNAS LEVLSTEPGS FKVDTASNLN SGKEDHSESS
NTENRRTSND DKQESCSEKI KLAEEGSDED LDLVQHQIIS ECSDEPKLKE LDSQLQDAIQ
KMKKLDKILA KKQRREKEIK KQGLEMRIKL WEEIKSAKYS EAWQSKEEME NTKKFLSLTA
VSEETVGPSH EEEDTFSSVF HTQIPPEEYE MQMQKLNKDF TCDVERNESL IKSGKKPFSN
TEKIELRGKH NQDFIKRNIE LAKESRNPVV MVDREKKRLV ELLKDLDEKD SGLSSSEGDQ
SGWVVPVKGY ELAVTQHQQL AEIDIKLQEL SAASPTISSF SPRLENRNNQ KPDRDGERNM
EVTPGEKILR NTKEQRDLHN RLREIDEKLK MMKENVLEST SCLSEEQLKC LLDECILKQK
SIIKLSSERK KEDIEDVTPV FPQLSRSIIS KLLNESETKV QKTEVEDADM LESEECEASK
GYYLTKALTG HNMSEALVTE AENMKCLQFS KDVIISDTKD YFMSKTLGIG RLKRPSFLDD
PLYGISVSLS SEDQHLKLSS PENTIADEQE TKDAAEECKE P
