ID   ALDH_VIBCH              Reviewed;         506 AA.
AC   P0C6D7; P23240; Q9KTS0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Aldehyde dehydrogenase;
DE            EC=1.2.1.3;
GN   Name=aldA; OrderedLocusNames=VC_0819;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KP8.56;
RX   PubMed=1902210; DOI=10.1128/jb.173.9.2842-2851.1991;
RA   Parsot C.R., Mekalanos J.J.;
RT   "Expression of the Vibrio cholerae gene encoding aldehyde dehydrogenase is
RT   under control of ToxR, the cholera toxin transcriptional activator.";
RL   J. Bacteriol. 173:2842-2851(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=9501228; DOI=10.1073/pnas.95.6.3134;
RA   Karaolis D.K.R., Johnson J.A., Bailey C.C., Boedeker E.C., Kaper J.B.,
RA   Reeves P.R.;
RT   "A Vibrio cholerae pathogenicity island associated with epidemic and
RT   pandemic strains.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:3134-3139(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: May be involved in V.cholerae virulence, as its expression is
CC       under the control of ToxR, a transcriptional activator of several genes
CC       associated with virulence.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC         Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.3;
CC   -!- PATHWAY: Alcohol metabolism; ethanol degradation; acetate from ethanol:
CC       step 2/2.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF93982.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M60658; AAA03051.1; -; Unassigned_DNA.
DR   EMBL; AF034434; AAC12273.1; -; Genomic_DNA.
DR   EMBL; AE003852; AAF93982.1; ALT_INIT; Genomic_DNA.
DR   PIR; A82276; A82276.
DR   PIR; T09437; T09437.
DR   RefSeq; WP_000640055.1; NZ_LT906614.1.
DR   AlphaFoldDB; P0C6D7; -.
DR   SMR; P0C6D7; -.
DR   STRING; 243277.VC_0819; -.
DR   PRIDE; P0C6D7; -.
DR   DNASU; 2614486; -.
DR   EnsemblBacteria; AAF93982; AAF93982; VC_0819.
DR   GeneID; 57739523; -.
DR   KEGG; vch:VC_0819; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_0_2_6; -.
DR   OMA; HGIGYYP; -.
DR   UniPathway; UPA00780; UER00768.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006068; P:ethanol catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase; Reference proteome; Virulence.
FT   CHAIN           1..506
FT                   /note="Aldehyde dehydrogenase"
FT                   /id="PRO_0000056465"
FT   ACT_SITE        262
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        301
FT                   /evidence="ECO:0000250"
FT   BINDING         240..245
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   506 AA;  55885 MW;  69E7F561D6CFED07 CRC64;
     MIYPIPNSET STVHFKDVYD NYIGGQWMKP HSGEYFSNTS PVNGLVFCRV ARSSSQDVEL
     ALDAAHNALE SWSTTSAVER SNILLRIADR IESNLETLAI VESWDNGKPI RETLAADLPL
     TIDHFRYFAA CIRSQEGAAS ELDSRTLTYH LPEPIGVVGQ IIPWNFPLLM AAWKLAPALA
     AGCTVVLKPA EQTPVSILFL MEIIGDLIPA GVINVVNGFG SEAGNALATS QRIDKLAFTG
     STEIGNHILK CAADNLIPST IELGGKSPNI YFPDIFSHED QYLDKCIEGA LLAFFNQGEV
     CTCPSRILVH ESIYEKFIAK IIERVALIKQ GNPLDTETQI GAQVSKEQYD KILGYIQIGK
     DEGAELIFGG HPNNQENYLS GGYYIKPTLF FGHNQMHIFQ EEIFGPVIAI TKFKDEIEAL
     HLANDTVYGL GAGVWTRDIN IAHRMAKNIK AGRVWVNCYH AYPAHAAFGG YKKSGIGRET
     HKLTLSHYQN IKNVLISHEI HPLGLF