FSIP2_HUMAN
ID FSIP2_HUMAN Reviewed; 6907 AA.
AC Q5CZC0; Q53TL3; Q53TN5; Q5HYH2; Q6ZTZ5; Q6ZU14; Q6ZU21;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-JUL-2010, sequence version 4.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Fibrous sheath-interacting protein 2;
GN Name=FSIP2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 216-1736 AND 5244-6907 (ISOFORM
RP 1).
RC TISSUE=Colon carcinoma, Fetal kidney, and Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5499-6907 (ISOFORM 1), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2495-6907 (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP VARIANTS PHE-700 AND THR-2764.
RX PubMed=26477546; DOI=10.1016/j.ajhg.2015.09.009;
RG Care4Rare Canada Consortium;
RA Srour M., Hamdan F.F., McKnight D., Davis E., Mandel H.,
RA Schwartzentruber J., Martin B., Patry L., Nassif C., Dionne-Laporte A.,
RA Ospina L.H., Lemyre E., Massicotte C., Laframboise R., Maranda B.,
RA Labuda D., Decarie J.C., Rypens F., Goldsher D., Fallet-Bianco C.,
RA Soucy J.F., Laberge A.M., Maftei C., Boycott K., Brais B., Boucher R.M.,
RA Rouleau G.A., Katsanis N., Majewski J., Elpeleg O., Kukolich M.K.,
RA Shalev S., Michaud J.L.;
RT "Joubert Syndrome in French Canadians and Identification of Mutations in
RT CEP104.";
RL Am. J. Hum. Genet. 97:744-753(2015).
RN [5]
RP INVOLVEMENT IN SPGF34, FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=30137358; DOI=10.1093/humrep/dey264;
RA Martinez G., Kherraf Z.E., Zouari R., Fourati Ben Mustapha S., Saut A.,
RA Pernet-Gallay K., Bertrand A., Bidart M., Hograindleur J.P.,
RA Amiri-Yekta A., Kharouf M., Karaouzene T., Thierry-Mieg N.,
RA Dacheux-Deschamps D., Satre V., Bonhivers M., Toure A., Arnoult C.,
RA Ray P.F., Coutton C.;
RT "Whole-exome sequencing identifies mutations in FSIP2 as a recurrent cause
RT of multiple morphological abnormalities of the sperm flagella.";
RL Hum. Reprod. 33:1973-1984(2018).
CC -!- FUNCTION: Plays a role in spermatogenesis.
CC {ECO:0000305|PubMed:30137358}.
CC -!- SUBUNIT: May interact with AKAP4. {ECO:0000250|UniProtKB:A2ARZ3}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5CZC0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5CZC0-2; Sequence=VSP_039412, VSP_039413;
CC -!- TISSUE SPECIFICITY: Predominantly expressed in testis.
CC {ECO:0000269|PubMed:30137358}.
CC -!- DISEASE: Spermatogenic failure 34 (SPGF34) [MIM:618153]: An autosomal
CC recessive infertility disorder caused by spermatogenesis defects that
CC result in multiple abnormalities of sperm flagellum, including
CC irregular-caliber, short, coiled, or absent flagella.
CC {ECO:0000269|PubMed:30137358}. Note=The disease may be caused by
CC variants affecting the gene represented in this entry.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAY14863.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AK126051; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAI46017.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAI46017.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC007966; AAY15001.1; -; Genomic_DNA.
DR EMBL; AC008174; AAY14863.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BX647691; CAI46017.1; ALT_SEQ; mRNA.
DR EMBL; BX648733; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; CR936597; CAI56743.1; -; mRNA.
DR EMBL; AK126036; BAC86406.1; -; mRNA.
DR EMBL; AK126051; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK126089; BAC86432.1; -; mRNA.
DR CCDS; CCDS54426.2; -. [Q5CZC0-1]
DR RefSeq; NP_775922.3; NM_173651.3. [Q5CZC0-1]
DR IntAct; Q5CZC0; 4.
DR STRING; 9606.ENSP00000344403; -.
DR GlyGen; Q5CZC0; 6 sites, 6 N-linked glycans (6 sites).
DR iPTMnet; Q5CZC0; -.
DR PhosphoSitePlus; Q5CZC0; -.
DR BioMuta; FSIP2; -.
DR DMDM; 300669711; -.
DR EPD; Q5CZC0; -.
DR jPOST; Q5CZC0; -.
DR MassIVE; Q5CZC0; -.
DR MaxQB; Q5CZC0; -.
DR PaxDb; Q5CZC0; -.
DR PeptideAtlas; Q5CZC0; -.
DR PRIDE; Q5CZC0; -.
DR ProteomicsDB; 62734; -. [Q5CZC0-1]
DR ProteomicsDB; 62735; -. [Q5CZC0-2]
DR Antibodypedia; 51870; 42 antibodies from 10 providers.
DR DNASU; 401024; -.
DR Ensembl; ENST00000424728.6; ENSP00000401306.1; ENSG00000188738.16. [Q5CZC0-1]
DR GeneID; 401024; -.
DR KEGG; hsa:401024; -.
DR MANE-Select; ENST00000424728.6; ENSP00000401306.1; NM_173651.4; NP_775922.3.
DR UCSC; uc061qle.1; human. [Q5CZC0-1]
DR CTD; 401024; -.
DR DisGeNET; 401024; -.
DR GeneCards; FSIP2; -.
DR HGNC; HGNC:21675; FSIP2.
DR HPA; ENSG00000188738; Tissue enriched (testis).
DR MalaCards; FSIP2; -.
DR MIM; 615796; gene.
DR MIM; 618153; phenotype.
DR neXtProt; NX_Q5CZC0; -.
DR OpenTargets; ENSG00000188738; -.
DR Orphanet; 276234; Non-syndromic male infertility due to sperm motility disorder.
DR VEuPathDB; HostDB:ENSG00000188738; -.
DR eggNOG; ENOG502S41A; Eukaryota.
DR GeneTree; ENSGT00680000100018; -.
DR HOGENOM; CLU_000048_0_0_1; -.
DR InParanoid; Q5CZC0; -.
DR OMA; SYSYPQA; -.
DR OrthoDB; 9535at2759; -.
DR PhylomeDB; Q5CZC0; -.
DR PathwayCommons; Q5CZC0; -.
DR SignaLink; Q5CZC0; -.
DR BioGRID-ORCS; 401024; 14 hits in 1039 CRISPR screens.
DR ChiTaRS; FSIP2; human.
DR GenomeRNAi; 401024; -.
DR Pharos; Q5CZC0; Tdark.
DR PRO; PR:Q5CZC0; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q5CZC0; protein.
DR Bgee; ENSG00000188738; Expressed in sperm and 100 other tissues.
DR ExpressionAtlas; Q5CZC0; baseline and differential.
DR Genevisible; Q5CZC0; HS.
DR GO; GO:0097224; C:sperm connecting piece; IDA:UniProtKB.
DR GO; GO:0097229; C:sperm end piece; IDA:UniProtKB.
DR GO; GO:0097225; C:sperm midpiece; IDA:UniProtKB.
DR GO; GO:0097228; C:sperm principal piece; IMP:UniProtKB.
DR GO; GO:0030317; P:flagellated sperm motility; IMP:UniProtKB.
DR GO; GO:0061512; P:protein localization to cilium; IMP:UniProtKB.
DR GO; GO:0007288; P:sperm axoneme assembly; IMP:UniProtKB.
DR InterPro; IPR038891; FSIP2.
DR InterPro; IPR031554; FSIP2_C.
DR PANTHER; PTHR47315; PTHR47315; 1.
DR Pfam; PF15783; FSIP2; 5.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome;
KW Repeat.
FT CHAIN 1..6907
FT /note="Fibrous sheath-interacting protein 2"
FT /id="PRO_0000331750"
FT REGION 273..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 954..990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1545..1573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3202..3257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5650..5672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5725..5781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5850..5880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6852..6874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 5738..5766
FT /evidence="ECO:0000255"
FT COMPBIAS 443..458
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5725..5741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5742..5774
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 430
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A2ARZ3"
FT VAR_SEQ 3464..3466
FT /note="VFS -> GRC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039412"
FT VAR_SEQ 3467..6907
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039413"
FT VARIANT 306
FT /note="M -> V (in dbSNP:rs9808218)"
FT /id="VAR_042938"
FT VARIANT 700
FT /note="L -> F"
FT /evidence="ECO:0000269|PubMed:26477546"
FT /id="VAR_075707"
FT VARIANT 2764
FT /note="P -> T (in dbSNP:rs201794247)"
FT /evidence="ECO:0000269|PubMed:26477546"
FT /id="VAR_075708"
FT CONFLICT 241
FT /note="T -> A (in Ref. 2; CAI56743)"
FT /evidence="ECO:0000305"
FT CONFLICT 336
FT /note="K -> R (in Ref. 2; CAI56743)"
FT /evidence="ECO:0000305"
FT CONFLICT 430
FT /note="S -> P (in Ref. 2; CAI56743)"
FT /evidence="ECO:0000305"
FT CONFLICT 1288
FT /note="R -> Q (in Ref. 2; CAI56743)"
FT /evidence="ECO:0000305"
FT CONFLICT 2499
FT /note="R -> M (in Ref. 3; BAC86432)"
FT /evidence="ECO:0000305"
FT CONFLICT 2808
FT /note="T -> I (in Ref. 3; BAC86432)"
FT /evidence="ECO:0000305"
FT CONFLICT 2895
FT /note="F -> L (in Ref. 3; BAC86432)"
FT /evidence="ECO:0000305"
FT CONFLICT 2900
FT /note="K -> E (in Ref. 3; BAC86432)"
FT /evidence="ECO:0000305"
FT CONFLICT 5357
FT /note="E -> D (in Ref. 2; BX648733)"
FT /evidence="ECO:0000305"
FT CONFLICT 5523
FT /note="N -> D (in Ref. 3; AK126051)"
FT /evidence="ECO:0000305"
FT CONFLICT 5564
FT /note="I -> V (in Ref. 2; BX648733)"
FT /evidence="ECO:0000305"
FT CONFLICT 5583
FT /note="Y -> N (in Ref. 3; AK126051)"
FT /evidence="ECO:0000305"
FT CONFLICT 5649
FT /note="I -> T (in Ref. 2; BX648733 and 3; AK126051)"
FT /evidence="ECO:0000305"
FT CONFLICT 5775
FT /note="R -> Q (in Ref. 3; AK126051)"
FT /evidence="ECO:0000305"
FT CONFLICT 5824
FT /note="L -> P (in Ref. 2; CAI46017)"
FT /evidence="ECO:0000305"
FT CONFLICT 5960
FT /note="R -> H (in Ref. 3; AK126051/BAC86406)"
FT /evidence="ECO:0000305"
FT CONFLICT 6165
FT /note="L -> Q (in Ref. 3; AK126051/BAC86406)"
FT /evidence="ECO:0000305"
FT CONFLICT 6526
FT /note="G -> E (in Ref. 2; CAI46017)"
FT /evidence="ECO:0000305"
FT CONFLICT 6591
FT /note="T -> I (in Ref. 2; BX648733)"
FT /evidence="ECO:0000305"
FT CONFLICT 6622
FT /note="P -> S (in Ref. 2; CAI46017)"
FT /evidence="ECO:0000305"
FT CONFLICT 6644
FT /note="V -> E (in Ref. 3; BAC86406)"
FT /evidence="ECO:0000305"
FT CONFLICT 6730
FT /note="T -> I (in Ref. 2; BX648733)"
FT /evidence="ECO:0000305"
FT CONFLICT 6736
FT /note="Q -> R (in Ref. 2; CAI46017)"
FT /evidence="ECO:0000305"
FT CONFLICT 6760
FT /note="M -> V (in Ref. 2; BX648733)"
FT /evidence="ECO:0000305"
FT CONFLICT 6794
FT /note="M -> V (in Ref. 2; BX648733)"
FT /evidence="ECO:0000305"
FT CONFLICT 6883
FT /note="T -> A (in Ref. 2; BX648733/CAI46017 and 3;
FT AK126051/BAC86406)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 6907 AA; 780607 MW; B0E81A627B82ABA2 CRC64;
MELYLGACSK PAKVAVTKTV ASVLAADTQQ CRDGVHKTHF AGVGPAQLLD LPLGVKLPVI
PGSNAVFYTT NFGEKLFRPS YGFNLTDPYC RLLENQYKSL HDPHLKAYYK RKDILKRLKK
GGYITSNNKV VCTLRELNKY RQYLTSLKLD FERNYIKEQR ILAKQLHNIP ENNQIPQHCD
VAQVQNWLLK EGTESIKDQE RLMRHRYLDM ISRKLEQLER TAEEQRLFLM DREERRQREH
TRRKLTLRRK IEEEWKTKEM LLLTRMAEDV KREERIEEQQ HRNREESDRK KQDLLEKKMA
YHLQKMQDTG FNGEDIGKNT FKYRGQDGTH ASPKNKKKTS EDIMLVYPAG DQNTYKETHG
HTANAAHQRQ NSSNNFTKKN SASVVYQADV QDNGINQKRD GMVSKNSSIF DDRGGINISG
QGSIISAQVS PTRNFSRVSQ AFLDPSKEEK ETNADWDGRP TKRSSYLCES GPQAHATDPG
IFSSPVYTNM QQNLLQNCLQ EKVTSEELNI IIQNVMTWVV ATVTSILYPA ITKYEKRLQN
NTYPVSDDSI LSSDSSSFCS TCSEDFTYRS YTSATTKTFQ AEPCAFVVDT SVRRPTTPIK
PPPAHVEKTV VGKTCHIKGQ SIISKHKYNK TNLLYSYPKL RSCKSDSHLL ASFETGTKKS
KDATTETDSL GSSLHCDKTA KAMDEMKNLK NVFVNFKCYL KGETEVILES ILREIMSDLT
QAIPSLSSVT AEVFVEQCER EKEILLSNAH IPSVASEIVE NMLEKLESAV EKKCVEMFSQ
DLSVDIKPSL AASDELLTSS NGKPLKNSMP HTLDPMCDIA EDMVHAILEK LMTLVSFKQN
EFLHLKDTNK LSCQQHKTDP ICMFLQRAGK NKSSLESDEA SLIVNEEVQN LISNIFSQSS
LVAYIEEAIN AILGYIQTEL NNERIIASEE TVVLLQLLED ILFQLHQEPV NESFQKSRQP
RISSPSDTKE KYRLTGTRLS NSPRSGRPFP PINVPGMVLY SDDENEEIDN IVKNVLDSTF
KDEKVKSQEQ IPNHWFTKGN TCFECKRNIK PPTKPGSRSK AAFHDWELKT EPPSTNHEDI
LKKKLSSNKD ISTFSQDQKH QIEKASENIV TSILKEMLKD ISSVPFGHLD SKTGSEASVL
VSEKPQGLSH QEWIDQMFSV SEISTVAQEI TDSVLNILHK ASNYISNTTK SSISSSVHQI
SLHNSDTEHI VKEAPNKYPL KTWFDSEKKM KYLSLFDVDP EKPPWLKSGK SEPKPVDDIN
DKIIRTIFKR LKSFICPKLH MGFKSSLRSQ LSKYTAKIVN IVLCAIQNEL ELHKENLNLR
EIDHTKSLTD KGFFANTDKK LESLVTSIDD DILASPLLTC IYDMLLSSEN AHQRSISLSS
RKPKSATDSV DVQSILPNRQ DKKSFHKYLA TPCTHHSVNG GNHIKENAKL QVLERIGETL
HEMLSKLLGT HLHSQLSCSQ QSREMTNKNQ KMAAALQSNI QLISKAILDY ILAKLCGVDM
DTSFASCGLK AISESLDIDN PSFASIIEKM AKSTKIISSI VSRRVQEDNK EETKSKAKPV
APVSSKTPST KEMHPNKLKA VASDILNMVF AKLEGFANGH LEILGAINDG NKKSNKIGWE
YESTNISRDT HEASFLSALY MHAKKVSSAI LKVIQTELNV TSSDLKTSVE NPPPETQILK
YVVKLILDAV SSDMFNEMES EGGGIETYRY RPTYGSLPGG AESDSFLEDD AYTAKKIIDE
RSPQREEVKT RSLKQWALEK TLNKIEVKLK EPHISPIAPI IRNILNEIFQ STLINQLNVL
SLSHSNFNGM PHNVDEPTPQ TSVQFMDKMM DPLLSEADIT IVTDNIVRTV FHKLYSAAMT
ERNVRENRYK TITFSANVSS HEHTYKGKSS VTALDENPCT FQSRFSVADK ETKVNLAEDI
VQAILTNLET FATSKVKSLF YSQVNFTVPV ALPIQQDHST LSKALSAKDS YSDEQFSCCS
VDHTKSGKTN LCQLSLSKLN TYALQVARRN LQGIKQELDK ERENPFLTHD IGISESIASQ
IVNALLDIIS RKGKCDKNSS DKEIDLDQQK GVIEKLLNET KYRKVLQLQI QDTIEGILCD
IYEKTLFQNN LSFATPTLKC SIADKHSEEN SEMFMEGANK IIPKLSVPKS DVILISNDIV
NIVLHNLSSA ATLVINAKNP TSARLPLTFC DTFPKIDCQQ PLKGSKTERK TERFSYSRNQ
KSAYADDNQI TVVEKEDTQK SATDSCEENA NFITKTIFKR LESFATERID SLITLAFQSK
EKSFVIPELE NCKQNDSIFY DSSQVESDVN VLKISATETI LSQELTDFTF VGRREKLGST
IHLSQARLKT YADVIASAIL KLIKNDLDLE IQKIYPYQNN ILFQENIIVS EIVDSMLKML
DDKRSVKEIC FNSKENSNFS QLALSNEILL GHKEKERSTK QSLFTKYPLE QNQMILENKR
QIIVLEEIFM RNGESKNKEK GELLIAVEEL LNKLYQRVRE VTGHLPPLNE TANFISNSKI
KTSDTTQKNS FQSHINSVAN DIVESVLGKM YLVVVTSLYE NNKSRTEVEI SDHNDSLLMK
PLRFRETKQA GKISNSPRYA ISQAYSYVDS QNISVMENTL LPYLPLQVKK DLIQMVLNKI
TNFVSLPLKV SPKDNPKPCF KAHLKTRSKI TTLPKFTKKT HLGLSAAKAK SKTKLGPGEK
TLKDSRSKTA IGLSHIMSAG DAKNLLDTKL PTSELKIYAK DIIINILETI VKEFGKVKQT
KALPSDQIIA AGKIVNTVLQ ELYVTNNCNL AYPMKSSHLR LSQGNIGTGS LPKQQACFYL
ENVSSQLEHI FPREGIFKKL FDKWQTESND KENEKCKLLM IAENVLTEIS IKAKELEYSL
SLLNLPPLEN CESRFYNHFK GASTRAEDTK AQINMFGREI VEMLLEKLQL CFLSQIPTPD
SEETLSNSKE HITAKSKYGF PNKHSLSSLP IYNTKTKDQI SVGSSNQIVQ EIVETVLNML
ESFVDLQFKH ISKYEFSEIV KMPIENLSSI QQKLLNKKML PKLQPLKMFS DKSESNTINF
KENIQNILLR VHSFHSQLLT YAVNIISDML AVIKNKLDNE ISQMEPSSIS ILKENIVASE
IIGTLMDQCT YFNESLIQNL SRESLFQGAE NAYTVNQVEL ATNMKMFTSK LKEGSLGINP
SQVSKTGFVF CSDEDMKEKY RVSSDLPTSV RSSVEDTVKN SEPTKRPDSE TMPSCSTRNK
VQDHRPRESN FGSFDQTMKG NSYLPEGSFL QKLLRKASDS TEAALKQVLS FIEMGKGENL
RVFHYENLKP VVEPNQIQTT ISPLKICLAA ENIVNTVLSS CGFPSQPHTN ENREIMKPFF
ISKQSSLSEV SGGQKDNEKS LLRMQDKKIN YIPEEENENL EASREDSSFL QKLKKKEYPK
IETVKEVEAF TFADHEMGSN EVHLIARHVT TSVVTYLKNF ETTVFSEEKM SVSTWSRKKY
ESKQFLRNIY DDSSIYQCCE HLTESVLYHL TSSISDGTKK GREKEKAWEI QEATFSKIIS
IHSQVFESRS ISIGELALCI SEIIIKILFN NKIIQADIAQ KMVAIPTKYT YCPGIVSGGF
DDLFQDLLVG VIHVLSKEIE VDYHFESNVR NKSFSMHRNN SVPLCNKINR QASPRDWQFS
TQQIGQLFQK NKLSYLACKL NSLVGNLKTS ESKEVVNKVF NIVSDLFSPD ECLDTGMDSG
KIQRTYFYSS NNEQPNSILT NNLQLSSKSV FLLNVVCEKL IRILLEECTS TAFPDKGSVS
EETSAEECQL LKMLQSVEDG KSDYRKGGMD CECLQVDYMS DLLENVAEID QDLLTSDSML
TIISHSLVKS LMDKLSHSIQ QAPESLPFAN KHLNYRTREI QSSFIKARKS ELIELGQSKS
SLELRSYDSN SLTVSLNNPS VVSSKIQAPF NKHCAVKSSS VSPFERQRTK EMDKVAIHNK
LHQEGIYAGV YSATFLEGII SELFFNLSMS LWGKNKNITV SWLNEMNTLF VNNVVNEFNN
AQVTVLRNAE ERLCFPPVHT ETVSKIVDSV YYDVLQQYEL KVACGNNPVY DNASIAEQIT
NGILLEILDY KLPSCFKEHL IPHSYYPLKP EIILQKLQSN LTEFTSLPRS SSDYSTMLSH
SFLEDVIRRL LSQLIPPPIT CSSLGKKYLM SSDFNEMSTC IINKVMSAIS KHKIWFTIYD
NQYLYTGKNL QKMVDSVYCN ILQMSDSLVS IQKSIVSRSP IMIDQIASFI IQEIIENHLQ
PFLSGEVLCH PRTPLDPVST IVTQVLSEVI ESHRPQKQSP LDIHLDSFVR EIVARLLSKI
FSPKHNTEIE LKNMTQRIVN SINRHFNKAK IHILYDDKEQ AFFSFNTDIV DELATSVYRN
ALKQHGLDLA VDKESEDSGI FVENITNLIV AAISDYLLHP LFSGDFSAST YSNSVAENIV
QDILSNISKS TEPSQSVPLY NTLLPYTFLE DMIRVLLSKL FSSASSLVLN RDTQKDISRV
NFNDIASNLV SDIRMKVSQH EIRFSKEEEE TKFIYSEDDI QHLVDSVFAN VVQTSGSQES
AVQNITSSND ILIDRIAGFI IKHICQKHLQ PFVSGKSLSS SDTYFDDERR QLFYTSVYSS
TFLEDVISGV LRKIFHRVVG IVQTKSIRDS EDELFEKAEE LIHLITGEFS KAQVSIIDNT
EERLCLPPVE RDVVKTIVDM VYSKVLQEYE MEVVPNKDFL NDTKTLAARI TNIILAEIFD
FQIHPDLIAN LPFKSHSKLS ANVLIQRVQY DISKSRFQRQ ASTMYTTMLS HSHLEKIVTQ
LTSQISPLNT SAEQSDTTKS DLSNTVIKLI NEIMSIISKH EICIIKYGNK KQSMISAKDI
QSMVDSIYAD LSHSNIYQSI TKDKKSISDI PVSKIASFII KEIFNHHIQS FLSEDKTLLL
AAVDQTYKLK AIDPKQRELS FIVNSSVFLE EVISELLCKI LYAFSHNMLV TENPDRVKLK
LTRIVTTLVN SIVLEFTTSE ILVADNFDKN LCFSERYKEM VQKIVNSVYG KVLDQYKSLI
QIHRVIQSDT ICFGRKIYYL LLEEIYDYQV QSLVSGELES SSYSYPQADN IIRNVLNIIT
KDSHALPPYI TVLPHSLLED MVYRLLGHVF PSTHTENELK EKKFPPDDEF VEAASKLTDE
IIKEISEHEI RLSMAEDNAE SMQLEPIENL VDSICNNILK TSEFQAEVQK DADKKGCSFL
SKLAGFIMKE IMYHHLQPFL HGEESSFSDL SDYDHVSELA KSGKEKTQPS LYSATFLEDI
IIDLVHKFCS LLIITEDSKK NEMAELDIMG LALKLANSLI REFKKSDIKV LPNAEKMFSF
PPIDKETVDK ISNFVYEQFI EKCTSHDIQK GDESNIAIGM IAALTQKAIS AFRIQPLFSG
DWSSTFFSFL NPDNITQRVQ HLPQNTFTQI SRCAKENQLS LPDQSYKDTS STPDCKNMMS
TLEINRGTMN RKKSFKTKDT SVKKGDIQNP VLSSINAIMK SGMINLTSGL ATGVTNKKEV
DENKVGICTQ KHSENVSKVT STTTVKSKDT QEPNLSETFN NNEIEKKRNL IPTDKKGKDD
EIYTHFSLII DDTEYEKEVL GSDSEIGYKK KIDNARESSF KKDDKLFQLS SLKSKRNLGT
TTDTLEIRIR TSSNEGRRDS PTQTCRDEEH HSDYEHVQNV IENIFEDVLE LSSSPEPAYY
SKLSYDQSPP GDNVLNVIQE ISRDSAQSVT TKKVSSSTNK NISAKEKEEE EREKEKVREE
IKSEPSKPDD PQNQRESKPG IFPAKFLEDV ITEMVKQLIF SSIPETQIQD RCQNVSDKQN
QAKLYDTAMK LINSLLKEFS DAQIKVFRPD KGNQFPGGKV SSVPKVPPRY KEPTTDEAPS
SIKIKSADKM PPMHKMMRKP SSDKIPSIDK TLVNKVVHSS VCNILNDYGS QDSIWKNINS
NGENLARRLT SAVINEIFQR QVNLIFCDEV SVSACLPLES KDVVKKVQKL AQTASKECQT
SSPYTIILPH KFLENVISAL FSKIFSTISS TKTKEPEDNL STELNFLQMK LVSAVATEIS
QDKYMTIQYV ETLQSDDDEI IQLVVQSVYN NLLPQFGSQE IIQNCVTSGC KILSENIVDL
VLREVASNQL QSYFCGELTP HQCVEVENIV EKILKDVFQT TDVPLPKPSH ADKLSYNIIE
EIAVKFLSKL LSIFPKVHKE RTKSLETDMQ KITSKVLNSV QEFISKSKIK LVPPTKESPT
VPVADNATIE NIVNSIYTSV LKHSGSYTSV FKDLMGKSNV LSDTIGFLMV NAISNSEFQP
QVEEEVSNSE LVLEAVKIME KVIKIIDELK SKEKSSSRKG LTLDAKLLEE VLALFLAKLI
RLPSSSSKDE KNLSKTELNK IASQLSKLVT AEISRSSISL IASDPEEHCL NPENTERIYQ
VVDSVYSNIL QQSGTNKEFY YDIKDTNTAF PKKVASLIID GVSSFPLDTI NSTISNADLS
GELDVNRIVQ KAQEHAFNVI PELEQEKLDQ NLSEEESPIK IVPHVGKKPV KIDPKIISEH
LAVISIKTQP LEKLKQECLK RTGHSIAELR RASISGRNYS LGSPDLEKRK TERRTSLDKT
GRLDVKPLEA VARNSFQNIR KPDITKVELL KDVQSKNDLI VRLVAHDIDQ VYLENYIKEE
RDSDEDEVVL TQTFAKEEGI KVFEDQVKEV KKPIQSKLSP KSTLSTSSLK KFLSLSKCCQ
TTASANIEST EAISNQVIES KETHVKRAVA ELDMATPKTM PETASSSWEE KPQCKKEEKN
LVTEPTHYFI HRIMSSSSYN QEDLISSTGE AEDCHSDPSA KILEESSQEQ KPEHGNSVKF
ITIFERSKDV LGSANPSKEV ISETPKPDVS KQGSKMLTKM SSTLSKVFSQ CNTNISRSSS
PAHQDEH
