ID   FSIP2_MOUSE             Reviewed;        6995 AA.
AC   A2ARZ3; A2ARZ1;
DT   04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 3.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Fibrous sheath-interacting protein 2;
GN   Name=Fsip2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   POSSIBLE INTERACTION WITH AKAP4, AND DEVELOPMENTAL STAGE.
RX   PubMed=12606363; DOI=10.1095/biolreprod.102.013466;
RA   Brown P.R., Miki K., Harper D.B., Eddy E.M.;
RT   "A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the
RT   sperm flagellum.";
RL   Biol. Reprod. 68:2241-2248(2003).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [4]
RP   TISSUE SPECIFICITY.
RX   PubMed=30137358; DOI=10.1093/humrep/dey264;
RA   Martinez G., Kherraf Z.E., Zouari R., Fourati Ben Mustapha S., Saut A.,
RA   Pernet-Gallay K., Bertrand A., Bidart M., Hograindleur J.P.,
RA   Amiri-Yekta A., Kharouf M., Karaouzene T., Thierry-Mieg N.,
RA   Dacheux-Deschamps D., Satre V., Bonhivers M., Toure A., Arnoult C.,
RA   Ray P.F., Coutton C.;
RT   "Whole-exome sequencing identifies mutations in FSIP2 as a recurrent cause
RT   of multiple morphological abnormalities of the sperm flagella.";
RL   Hum. Reprod. 33:1973-1984(2018).
CC   -!- FUNCTION: Plays a role in spermatogenesis.
CC       {ECO:0000250|UniProtKB:Q5CZC0}.
CC   -!- SUBUNIT: May interact with AKAP4. {ECO:0000305|PubMed:12606363}.
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in testis.
CC       {ECO:0000269|PubMed:30137358}.
CC   -!- DEVELOPMENTAL STAGE: First detected in testis of 16 day old mice.
CC       {ECO:0000269|PubMed:12606363}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAM17862.3; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAM17864.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AL845500; CAM17864.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL845500; CAM17862.3; ALT_SEQ; Genomic_DNA.
DR   SMR; A2ARZ3; -.
DR   STRING; 10090.ENSMUSP00000120314; -.
DR   iPTMnet; A2ARZ3; -.
DR   PhosphoSitePlus; A2ARZ3; -.
DR   EPD; A2ARZ3; -.
DR   jPOST; A2ARZ3; -.
DR   PaxDb; A2ARZ3; -.
DR   PeptideAtlas; A2ARZ3; -.
DR   PRIDE; A2ARZ3; -.
DR   ProteomicsDB; 266873; -.
DR   Antibodypedia; 51870; 42 antibodies from 10 providers.
DR   Ensembl; ENSMUST00000143764; ENSMUSP00000120314; ENSMUSG00000075249.
DR   MGI; MGI:2664111; Fsip2.
DR   VEuPathDB; HostDB:ENSMUSG00000075249; -.
DR   eggNOG; ENOG502S41A; Eukaryota.
DR   GeneTree; ENSGT00680000100018; -.
DR   HOGENOM; CLU_000048_0_0_1; -.
DR   InParanoid; A2ARZ3; -.
DR   OMA; SYSYPQA; -.
DR   PhylomeDB; A2ARZ3; -.
DR   TreeFam; TF342086; -.
DR   PRO; PR:A2ARZ3; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; A2ARZ3; protein.
DR   Bgee; ENSMUSG00000075249; Expressed in spermatid and 3 other tissues.
DR   ExpressionAtlas; A2ARZ3; baseline and differential.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0031514; C:motile cilium; IC:MGI.
DR   GO; GO:0097224; C:sperm connecting piece; ISO:MGI.
DR   GO; GO:0097229; C:sperm end piece; ISO:MGI.
DR   GO; GO:0097225; C:sperm midpiece; ISO:MGI.
DR   GO; GO:0097228; C:sperm principal piece; ISO:MGI.
DR   GO; GO:0030317; P:flagellated sperm motility; ISO:MGI.
DR   GO; GO:0061512; P:protein localization to cilium; ISO:MGI.
DR   GO; GO:0007288; P:sperm axoneme assembly; ISO:MGI.
DR   InterPro; IPR038891; FSIP2.
DR   InterPro; IPR031554; FSIP2_C.
DR   PANTHER; PTHR47315; PTHR47315; 3.
DR   Pfam; PF15783; FSIP2; 5.
PE   1: Evidence at protein level;
KW   Coiled coil; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..6995
FT                   /note="Fibrous sheath-interacting protein 2"
FT                   /id="PRO_0000353212"
FT   REGION          273..292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          308..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          351..476
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1452..1472
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2554..2595
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2699..2731
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3182..3270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5489..5665
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5719..5740
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5823..5878
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5943..5996
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6973..6995
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          665..692
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        357..398
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        399..418
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        419..439
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        440..455
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1454..1472
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3182..3208
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3220..3253
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5509..5628
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5635..5665
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5719..5739
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5829..5876
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5966..5992
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        6973..6988
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         430
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
SQ   SEQUENCE   6995 AA;  784857 MW;  FC847718F818E457 CRC64;
     MELYLSACSK TANVAANKAA SSTVAEDSQQ CVDGRHKTPI PGVGAAQLLD LPLGVKLPMI
     PGTDTVYFTT NISEKLFRPS YGFNLSDPYC RLLETQYKSL HDPHLRTYYK RKDILRRLKK
     GGYITSNNKI VCSLRELNKY RQYLTSLKLD FERNYLREQQ LISKQLHKLQ ETSQLPHCSD
     VTRFQNWLLQ DNTHSIKDQE RLLRHRYLDM ISKELEQLER TAEEQRLLRI DRDERRQREY
     TRKKLTLRRK IEEEWKTKEM MLLTKIGEDV KREQKIEEQR RKSREESDRK KQAMLEKKMA
     YHLQKMQDTG LKDDIGRNGF DYRGQNGTTF ESSSKKRKKQ FDDIKIVYPD GDQKAYRGTS
     GQVSATVNQS QSSSKDVTKV SASSVTYPAE VQNSSSEQKR SEVTKRLSDE RGKNSTDDSA
     RESIISTQLS PTRNAKLSQI SLDHQKEEKE MKSTWNGGLS KKSSYAGEPG SPTDAPPQGI
     FSFPVNSNTQ QNLQHCLKDK VTSEELNSII QNIMTWVVAT VTSILYPAIT KYEERVQNNT
     YPVTDDSDLS SDSSSFCSTC SEGFTYRNYT AKTLPVDPCT FASDMPIKKP PTPLKPPSAH
     VERTVIDQTY QRQGQSVPSQ VNYQKTSLDY QFPKIGSSKS DSHLLTSLET CTKKSKDATT
     ETESLEISLL YDKKAKAMDQ IKNLKNVFVN FKCHLKGETQ LILESIFQEI MSDLSQAIPS
     LSSVTAEVFV DQTETEREEL LSNVDICSVA SEIVENMLEK LESAVEKRCV QMFSQEDLSV
     DIKPSLSTSG DYLSSVETKP SEETLSYTLE PMCDVADDMV HAILEKLMIL ASYKKNDVPP
     EDTTKHFQQT KTEPIHKVHQ QTEQKKASFA SDPANQIVKE EIQSLISSIF SQSSLVGYVE
     EAISTILGYV QTELNNERLI ASEETVVLLQ LLDDVLTQLH QQPVKAGVKK PRRPRVRNLS
     DPEEKYRVTG TRPFNNLKSK RPFPPVNVPG MVLYSEDDDE EIDNFVQSVL DSSFNDEKSS
     SQEQVPNYWP KKRDTYFESK RSNKLPTKST FQNKVGSHDW GLKLELSLSS EDIVKTKHCL
     GQEPSIFSQD QKHQIQKASE NIVKHILTDM LKDMSSDSSS HLGSQTGKGA SAFISEKSQG
     LSDQEWMEQM FSVSEICAFA HEITDSVINI LHKASMHIPN TIKNAFTSVH PTHVAPFDTA
     HTSKETPSKM PFKVWFDSEK KMKYLSSLNM EHEKTSQLRS GKCEPKRVND ITDKITNTIF
     KRLKLFVCPK LQIGNKSSLI EKSLHSQLST YTMKIVNIIL HAIQSELEIN KTKPNLKETD
     HPKCHKNKGW FTDPNKVVES RVTSVNDDIM ESPLLTCICE MISSTNEDKK NTSTYTDKTL
     STSICESGNF HKQSILSNKQ DKNSFCQLLA KPCLQHSLAD EKDFKVSSKL EVLDQIGDTL
     HEMLGKLTGD HPDPQPSCSH QNTETIDKDP PTMSNTQLIS KAILENVLAK LCDVDIDTSI
     VNSGPKTVPE SLDIDNLSFA STMEEMAKCT NIISNIISKI MKDNKEVTKS KAKNDLPTSS
     KTEIPKEMCP QNLKNIASDI LNMVFAKLEH FASGSVVNVG NLNDENKKEH TVDWECESNS
     SPADSHDKSL QSTLYSHAKK VSNGILKAIQ TELNMNPPDC KTDKKRSPEE TQILTNIVDL
     ILDVVSSDMF AEPESENQSN ENYGYRPTYG NFLPGGAESD SFLDDDTQNK ELIRDATSFN
     EETRTLSTDQ MGLERTLSKI EVKLKEPHRS PIVPIIRNIL NEIFQSALIN QLNVFSLSRA
     HFSGMPQNAP TSSTQTSAHF MDQMMGPLVS DTDVSIVVND VVRTVFHKLY SAAMTERHVS
     ENRGKTIILS ANVSFRECTY GGNAPVSGLN ENVCDLQSSW NVDKQIKINV VEDIVQAILG
     NLETFAASKV ESLFCPQVKF TVPVTLPVMQ EEGSLSQALS GKDSYSDNQL PCLVDHGNPE
     QMDSWYQMSL SKLNIYAKDV ARKILQGIKH ELDKEQESPL LTNNIVVSEN IASQVVNKVL
     DIVSCKSKCD KKSSDKDHYS EQQVGIIEQL VNKREYRKIL EFQIQDTIEG ILCDIYENIL
     YQNNLSFATP TLKYGIPAKH SEANFEQVVM GTNIIPKVSV PKADVILVSK DIVDIVLHNL
     TSLVVLAINA KDSAPARVAI YDIFPKPQFQ QPLSITQRTE ETPGHFSHSK NKNLGSPDVY
     QVPVNGKEDT KELAPDPCKE NANRITQPIF NRLQSFATER INSLMTPAFQ SKGNVFVSPQ
     FEIGKDDNCI FHEPGQAESD VDVLKLTTRT VTSQELVEPI FTSCRENFGT TPHLSQTNLK
     DYAAFIASTI LKLIKNDLDL EVQSMHTYSS HILFQKNMIV SEIVNNILKI LPNKEPIKEF
     FLSSPENSSC SQLTISSEDL VGYKEKEKAT ALPQFTNDSL EENQVTVEKE SQRDVLEEIF
     MRKGESKPRE KTEILRTVEE VLKKLSQKIM EIIGHVAPFN ESPHTVSKSK SKTAAATQKK
     FFQSRINNVS NDILENVLSE MHSVVVTSLY RNNKSKREGE MHDSSDSSSV KPSGSRETKP
     TRKRSSPLRL GVPQMHPHAD NLNALVLENT ILPYSPLQIG KYLVQIVLEN LSNFVSLHLE
     EGYPPEGSYD DLYLLRLHNA KLSPKNSPRP GGKASLKMRS KINSLSKFKT KPHLGISSTK
     TKIKNKLSAG EKTPRESRSK TALGLPQTPQ VEDTKTTLKT KLPVAELRLY ATNIITDILQ
     VILSSLERAA QHRAMFNTKV LASSQILEAS KIVNAVLQEL YATNNDNLAS PINISSLSDR
     RLSKQNLGAG YPTEQPCFYL ENVSSQLEQI FPKEGILKKM FDKWQTETSD TETEKSKLLT
     IAENILTEIS IKAKDLEYSL SLLNLPPLEE CENRLYDRFK GVSTRAEDTN AQINMFGREI
     VEMLFEKLQL CFLSQMPTQD SNGILTSRKE HGTSKSKHGV PTKPILGGIQ TYNSKMADQV
     SMSPSNQIVH EIVERVLHML ESFVDLKFKH ISKYEFSEIV KMPIDNLFQA QQRQLSKKML
     PKLPFRKFGD ESKPGTIISK DDGQNTLLQV HLFHSELLTY SVTAVSGMLR IIKNKLDKEI
     SQMEPSPVSI LKENITASEI IGTLIDQCSH FEESLIKNLP TKHWFQGTEN VYIVNQVEFA
     TPVKMPPSNT SDTPRTRRSS QGSVSGMGFS SEDDMKEKYS VTSNSSSHIS SCVENTNKSL
     EPMGRSNSEA MPSGSRHKAH DHGQRKPNFT PFEQVTKTHN FLPQGSVLQK LFKKVNDSTE
     ESLKQVLSFI ETGKRENPRV FHYETTKSAE PNEIKTTAPP LKICLAAENI VNTVLSSYGF
     PHQPNTNEST ETMKPFFMSR QIPLSEVCEG QKDTEKTLLK TWYSRKALIQ EEESEGLEAC
     QEDFSLLHKW KNKKPQMTTE TVEETKTIVF ADHELGPNEM HLVARHVTTS VITHLKNFKT
     GVSTEKFSHV SSLSKKIDDA NQPLISIYSN SSVCQFCEHL SDAVICYLFL NISDGIKKCS
     REKAWEIQDA IIDKNVIIHS QLYKTRSISI GDLALSIFEV IVEVLANRNM INADKAHQAS
     IKAKYMFCPG VTSSDFDDIF QDLLKEVIFV LSKILGINHF ENNVRNKSYP TLKNNLPVFN
     KVNTIENQIG PRKLESSPPL TDQLAQKNKL NYLARRLNSL VGSLRSRESK EVVNEVFNIV
     LDLFLPDEIP DGDLSSGKLA KTFSSSNNQP SNRSLANNVG LSPKSIFLLN IVCEKLIRTL
     LEKCMGGTPF FEDSSLFREI PEECQHVKVL PSVQGGGFDY REAPMDCEQF QGDYMSELLE
     NLADVDQDLL SSDCILNVIS HSLVKSLMDK LSHGLQQAPF ENKYRNYRTR EMQPFITKAK
     RQELIEPEET KGHVGFMSYD NNFLTKSLNN TNANSFKKHT QFGKKHAGKS ISLSFSDGKE
     SRGINTACFH KLCQRGVNGG VFSATFLEEI ISELFYNLST SLWKKNPNIT EAWLNEINTL
     LINNVVKKLN DAEITVLRYP EERLYFPSAH KGCIAKIVDS IYYDVLQQYE FTVTCGGNLP
     YDNTPVAKRI SNSILLEVID YQLPSCFKGK LRSNLYHTLN AEIILYKLHN SLKNFNSEPM
     TSKDYSTMLP HSFLEYVIRR VLAQLISLPI KSSSLEKKYL ASSDFNEMSN CITNKVMSAI
     SKHKIWLTIY DNQCLYTDKN LQKMVDSVYS NILQMSSSVD SIQKNIISRS PIMIDQIASF
     IIQEIIENHL QPFLCGERLP RPKTPLDEVS YMVKQVLSDV VESHKSQKPS PFGIYPDKLV
     GETVTRVLSK IFSPNTNINV ELENVTQKIV SSVHKHLDKA KIPILCHKQP PFPFSNTDIV
     DELVTSVYKN VLKQHGLDPD IDESVNGEVF VENITKLITA AISDYLLHPL FSGDLPAASC
     SNSVTDHTVY DILGDINKSS KPNQTLPLYN TLLPYTFLED MIRVLLSKFF PSAPKIDSYK
     AASKDKEGVN FNEIASNLIS DIRRKISQHE IRFSKDEDKT KSFYSENDVQ HLVDAVFMNI
     LENYGSPESV EQNITKSNDV FIDQIAGFII KYICEHHLQP FLERKQLSTS SYKYSDDDRQ
     DLLYGSAYSS TFLEDVVSGV VSKIFHRVIG IVQVNSTINS ENILFDKAEN LIYWITEEFS
     KAQVTTIENA EERLSLSPVE GNILQKIIDT VYSKILEEHE MEIMPNKDFL NDTKALASQI
     TEIILSEISY FQIPPDLVAN LPLRLHSKLS QNVLVNKVHY DISKSRFRRQ ASTMYTTMLS
     HVHLEKIVTQ LMSQINPSDS SVGHSDTYQS ELSNTVVKLI NEIMSIISKH AICIVKHGNE
     KQSMISEKEM QSMVDSIYAD LSHSNLYQSL TKDKKGLSSI PVSKIANFII KEIFNHHLES
     FLSGDKSILS ASVAQTCKKK ATTSTKQREL SFIVNSAVFL EEVITELLCK ILQTFIQNSL
     SMETPERAIA EIMDIVTTLV KSIVFEFTSS EILVAEHLDE SLWFSETYKE MVQKTVNSVY
     GNIFYEYKSL TQLHRAVQYD TSGFGGKMYH FLLEEMYDYQ VQSLVSGELM PSCYASPQSA
     NIIKNVLNVI LKDTNALPSC ITVLPCSLIE NMIYKLLENI FPSDDTTNEL KKEEKEEAGP
     DDVDEFMAAA SKLTDEIIQE ISEHEIRFAN AEDTASMIYE TTENFIDSVC NNILKNSEFQ
     AEVQKDAHKK GGSFLSKIAG SIIKEIMDHY LQLFLYGEGS HSSKLPHFGG ASVVAKSGKE
     KAPSSLFSAA FLEDVIVDLA HKFCSFLTLT DDARKKDLPE AEIVSLAIKF ANSLIRDFRK
     SGIKVLPHAE EIFSFPPIAK ETIDEISNFV YDQFIGKLGA DGIQKDGTGN MVIEMVSSLA
     QKAISTFKIQ PLFSGDWCST FFSFLDAENI SQRVQLLPKE TSMQISGALK QNQLALSKIT
     SIKKDDTQDP ILNSIATIMK SNIINLLSGP SAGVTDAKKE DESKVKPATR ETTSPPTSPP
     ATMKSQGSQV QQLATSPPTS MKSQRIQVQQ SVMSPPTTMK GKGAQVQQFA TSPPTSMKSQ
     GSQVQQSAMS PPTTMKSRGA QVQESVTSPF TTKESRGAQV QQSAMSPPPS MKDRGAQVQE
     SSTSPPTTMK SRGAQVQHLS SKYKGNETGK ENLVLVNEQG QILEIFTHFA VAKTVENSPE
     KEVFISDLKI QNEKKLDVSK SSVKTDDRPM SKDKETMTEK TVLIPQQPVK EERKQSVVKT
     DTEEEQYSEN ECVENVIENI YDNVFIVSSQ EPLDFSRPIY SRSLTSDKAL VILKDSAQLV
     PAKDLSSSGH RDIAAKEKAS KETETKIRRD RSETKRSKEM KSKSSMTDHP KPSESKSKIV
     PAKFLEDVIA ELVNKLVFTF ISDKTTDTNE QKPGELYDTA MRLVNSMTKE LSDAEIKVFR
     PEKEDEVQAA KEPAPTSPPE VKETVTKEPS PSTNIKNEDQ MSDVQKTPEQ SSPDKLPALE
     KIPSIEKSIV NKIVHSCVCN IFKECKSQES ICENINSNGE NLAKRLTSTV INEIFQHQLN
     LIFSDEVPAS ACVPLESKDV EQKVQNVVQT VSKECQTASP YTVQLPYKFL EDVTSGLLAK
     VFSKLSNVKT KLTPENVLTQ LDFLQSNLVK TIAAEISKNE DLIIQYVESL HPNDDEVIQL
     VVQTIYNNLL PQFGSQEILQ KCIISGCKLL SKTIVDLVLR EVTGNQLQNY FGGELTPIQC
     AEVDNVVENI LTNVVLTTPS QPSGPRKLSY NIIETIAVKF LSKLLSVFPK GHPERTKSQE
     TEMRKITSKI LHSIQEFISK SKIKVVQPVK ESEAVPSADK AAIEKVVNSV YTNLLKHCGS
     PTSAFEDLMR KSDVISDIIG FSMVKEISNS EFQPQAEEEL SSSELALEAV KIMEKVVKII
     DELKSQEKPA SITDVMLDSR VLEEALALFL AKLVKTPGPA SKDTTSLTKP ELNKIASQLT
     KSVTAEISKS NISLVESNHE EQSLDPENIE VISQVVESVY SNVVKQSGTE NELSDIKGTK
     KAFPKKVASL IVDGVSSVPS CRVITESSYT AAHGDLDTNR IIEKAQKHAA LMSSDSDKDS
     KKELEDEFPV RIVPHVRNKP LRIDPNIVSD HLAVISMKTQ PLETLQMDCL KRTGCSIAEL
     RRNSIRGIGP SSTDVSEMGT RQKERRISLD RTGRLDVKPL EAVGRNSFQN VRRPDITRVE
     LLKDINNKTD LIIRLVAHDI GRKESDSSLS EGMVSDEEEV VLGEVVGDQC LRKISGGRVQ
     QVKKSAESHV VSSKTATSTS NLKRFLALSK CCQPTSGENI ESIEESGIQI MDPNKAYVKR
     AAAELDMPSC KSLAEETTSR DKLQYKEEEI LASEPTHYFI HRIMSTSSYN QEDLISGEAE
     EFLPDAKANA LEESCQEPQE GNSNSLEFVT IYKGSKHIAG SARLSKEHVS EMPRSSISKQ
     GSRVLAKVSS TLSKVFSRSS GSIPKSSSPP HQDKR