FSL7_GIBZE
ID FSL7_GIBZE Reviewed; 496 AA.
AC I1S160;
DT 12-SEP-2018, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2012, sequence version 1.
DT 25-MAY-2022, entry version 56.
DE RecName: Full=Fusarielin biosynthesis cluster transcription factor FSL7 {ECO:0000303|PubMed:22252016};
DE AltName: Full=Fusarielin biosynthesis cluster protein 7 {ECO:0000303|PubMed:22252016};
GN Name=FSL7 {ECO:0000303|PubMed:22252016};
GN ORFNames=FG10458, FGRAMPH1_01T08153;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
RN [4]
RP FUNCTION.
RX PubMed=22252016; DOI=10.1111/j.1462-2920.2011.02696.x;
RA Soerensen J.L., Hansen F.T., Sondergaard T.E., Staerk D., Lee T.V.,
RA Wimmer R., Klitgaard L.G., Purup S., Giese H., Frandsen R.J.;
RT "Production of novel fusarielins by ectopic activation of the polyketide
RT synthase 9 cluster in Fusarium graminearum.";
RL Environ. Microbiol. 14:1159-1170(2012).
CC -!- FUNCTION: Transcription regulator that specifically up-regulates the
CC gene cluster that mediates the biosynthesis of fusarielins F, G and H,
CC decaketide compounds with 5 methylations and a decaline core that act
CC as mycoestrogens as they stimulate growth of MCF-7 breast cancer cells
CC (PubMed:22252016). Probably binds the 5'-CGGNNNCCG-3' motif present in
CC the promoter of all the cluster genes (PubMed:22252016).
CC {ECO:0000269|PubMed:22252016}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR EMBL; HG970332; CEF75880.1; -; Genomic_DNA.
DR RefSeq; XP_011319437.1; XM_011321135.1.
DR AlphaFoldDB; I1S160; -.
DR SMR; I1S160; -.
DR GeneID; 23557363; -.
DR KEGG; fgr:FGSG_10458; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G08153; -.
DR eggNOG; ENOG502SV4P; Eukaryota.
DR HOGENOM; CLU_617607_0_0_1; -.
DR InParanoid; I1S160; -.
DR PHI-base; PHI:1766; -.
DR Proteomes; UP000070720; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..496
FT /note="Fusarielin biosynthesis cluster transcription factor
FT FSL7"
FT /id="PRO_0000444964"
FT DNA_BIND 16..46
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 57..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 496 AA; 54157 MW; 89CB51BEE6FAEF0D CRC64;
MSQPCKDSDA KLRAACDRCH ELKIRCTRTG GTESRCDRCE KNDIDCVYRA HRRIGRPKSQ
KSRCGPNTTA RQNDTTTRGR IQQEQQEQMD ISPPENRDSI NSDFDFSIFE ASGAVEWHRS
SDVINVSTHQ VSSTHPPFIS PDCSLSHESS MSQTGSGSPF SMLNIGTMPV CDLDLSTLHG
YGPSTDLVRS INHRSGSENE SMEGNAELQS TQSASGSPQE EDQMLEDRLL RHQAKLRCLY
STVDATRNLI STTNDTVSHG APLDKVLEAI MELVEILQTN ANHTSSSSSS NSTTVDGPSE
IRNQSRSRQD IANFNDIAIL HVSISYAYIV KILAPIILSL EKSSVPVGST SSSTYNDTTA
HPSSASLPSQ TGGPTKPRTV SVSLGSFSLA SKPALNAQIL LGMISRMLDQ LHDATQPILM
QVRHHHVPTQ PVALQEREHH DAAMTREQHV STGHGPDRHT SPVLSSAQAA VDSIRNEEKE
LLAKLNKVGN STSATW
