FSLB_DICDI
ID FSLB_DICDI Reviewed; 642 AA.
AC Q55CD6;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Frizzled and smoothened-like protein B;
DE Flags: Precursor;
GN Name=fslB; ORFNames=DDB_G0270730;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
RN [3]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=18559084; DOI=10.1186/1471-2164-9-291;
RA Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B.,
RA Skelton J., Ivens A., Bozzaro S.;
RT "Genome-wide transcriptional changes induced by phagocytosis or growth on
RT bacteria in Dictyostelium.";
RL BMC Genomics 9:291-291(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Down-regulated by phagocytic stimuli and growth on bacteria.
CC {ECO:0000269|PubMed:18559084}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72715.1; -; Genomic_DNA.
DR RefSeq; XP_646545.1; XM_641453.1.
DR AlphaFoldDB; Q55CD6; -.
DR SMR; Q55CD6; -.
DR STRING; 44689.DDB0230120; -.
DR PaxDb; Q55CD6; -.
DR EnsemblProtists; EAL72715; EAL72715; DDB_G0270730.
DR GeneID; 8617511; -.
DR KEGG; ddi:DDB_G0270730; -.
DR dictyBase; DDB_G0270730; fslB.
DR eggNOG; ENOG502T166; Eukaryota.
DR HOGENOM; CLU_030318_0_0_1; -.
DR InParanoid; Q55CD6; -.
DR OMA; LACWIRK; -.
DR PhylomeDB; Q55CD6; -.
DR PRO; PR:Q55CD6; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.10.2000.10; -; 1.
DR InterPro; IPR000539; Frizzled/Smoothened_TM.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like.
DR Pfam; PF01534; Frizzled; 1.
DR SUPFAM; SSF63501; SSF63501; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Disulfide bond; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..642
FT /note="Frizzled and smoothened-like protein B"
FT /id="PRO_0000371364"
FT TOPO_DOM 27..264
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..294
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..344
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 366..375
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..398
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 399..416
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..437
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 438..460
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 461..481
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 482..514
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 515..535
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 536..642
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 47..197
FT /note="FZ"
FT REGION 578..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 584..611
FT /evidence="ECO:0000255"
FT COMPBIAS 578..601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 80
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 153
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 162
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 177
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 203
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 222
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 261
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 482
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 52..123
FT /evidence="ECO:0000250"
FT DISULFID 65..116
FT /evidence="ECO:0000250"
FT DISULFID 143..194
FT /evidence="ECO:0000250"
SQ SEQUENCE 642 AA; 72406 MW; 1D6F38ED27056949 CRC64;
MFNKNNNNNK IIIILKLFLI ILIVNNNNNI KTFGLNLPDG YGAGLVDPTA TCSNYIGDSI
DQPLCNEKLP NYKNIYTSKN ITIQYINQKI VEKTFISLTF LQSKCFDLNF AEFGICDIYF
PPCFQTPTTI TPIKSVSLPQ RLCKSACERM VSNCSSLGAS LNCSDPLKFP RIATLYNLTD
YGFTANGGFF PVPCSDPLAT FENKSTTSEL IEICPSPLLL FNSSDPKYSA DRGYTYLTPT
NCVLPCVAPI YTEKKWHQMY NMSKILSTIS FVCSIYNVLT FGILNHRRSK YNYCITFFSA
SVIIITMMDI VTYGIGYEKL LCPEPGRFAV QSDVSCGATG ALFHIGITNG VFWWTTMSIC
LFAVVKRIKL FDFRYFIIFN TTASLISVII PLAGNAFMAG TGSLACWIRK TWYVNSVFWI
PCGIALTIGS VCIILVIYEI YKITKNVSTK DNRMILLQIK PFLCVTLVGG SFYYLFIFNF
DNESHSKEYK EKVVDYVMCL LSDTGKECLM AGPNYVAYFV FYFFIRLFGI TFFCIYGTSQ
NARDIWIHSK ILNHPNIKPF LLKYNIINFN SMTHYGSGTN PTSNSKNSKN NQNNQNNNSR
KEFESKNIEL EVNESISKGQ TTRGADDEEE SNINSASNTS SD
