FSLC_DICDI
ID FSLC_DICDI Reviewed; 635 AA.
AC Q86J18; Q555S3;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Frizzled and smoothened-like protein C;
DE Flags: Precursor;
GN Name=fslC; ORFNames=DDB_G0274287;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000012; EAL70036.1; -; Genomic_DNA.
DR RefSeq; XP_643987.1; XM_638895.1.
DR AlphaFoldDB; Q86J18; -.
DR PaxDb; Q86J18; -.
DR EnsemblProtists; EAL70036; EAL70036; DDB_G0274287.
DR GeneID; 8619413; -.
DR KEGG; ddi:DDB_G0274287; -.
DR dictyBase; DDB_G0274287; fslC.
DR eggNOG; ENOG502T166; Eukaryota.
DR HOGENOM; CLU_030318_0_0_1; -.
DR InParanoid; Q86J18; -.
DR PhylomeDB; Q86J18; -.
DR PRO; PR:Q86J18; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.10.2000.10; -; 1.
DR InterPro; IPR000539; Frizzled/Smoothened_TM.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like.
DR Pfam; PF01534; Frizzled; 1.
DR SUPFAM; SSF63501; SSF63501; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Coiled coil; Disulfide bond; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..635
FT /note="Frizzled and smoothened-like protein C"
FT /id="PRO_0000371365"
FT TOPO_DOM 21..244
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..275
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..314
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 336..356
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..377
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 378..398
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..419
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 420..440
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..461
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 462..496
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 497..517
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 518..635
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 32..166
FT /note="FZ"
FT REGION 559..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 594..623
FT /evidence="ECO:0000255"
FT COMPBIAS 559..596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..617
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 65
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 141
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 156
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 185
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 203
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 382
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 396
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 37..108
FT /evidence="ECO:0000250"
FT DISULFID 50..101
FT /evidence="ECO:0000250"
SQ SEQUENCE 635 AA; 72089 MW; 0B641BAD7E1FD917 CRC64;
MKFKLIIFII IIYIIKILKS EILNEFGYGL VDENLKCLSF IGDSNNQQLC NNKLINKQLI
YSTINKSNQI QSLKMVEQSF KQLTFLQGKC LNLNFAQFGI CDIYFPSCVE TSFGISLPKR
LCKSVCKQIV TDCPTLGVSL NCSDSNKFPT IGTLYNLTKY GYTENNGFYQ VECSNPTNYY
YNEINSTNNQ FIEICPSPLV LRNQSDSKYG EDKGYTYLSP TNCVLGCPQP FFKNNKWVQM
YKMSIVLSTL SFICSIYNII TFGLLSKLKS KYNLCITFFS VSTVLMSLMD IVTYGIGYEE
LLCPESGRYA IQSDVACGVT GAFFHIGITT GVLWWTTMSI CLYSEVKRFK MISFRYIIIF
NSVISLILLI IPLSGQAFMS GNGSLGCWIR KTWYANGTFW IPCGISLFIG AICIVLVIYE
IFKISRNLSK DNKPLMFQIR PFLCVLLVGG SFLYLFIFYF NNERNLDKYK AAIPSYVQCL
LSSDENGEDC LTDGPGFGAY FTFYFFTRLF GITSFSIYGT SKIARDIWFE SAYNHPFFNP
YIVKCLSLLG ISKHFSSNSI SGSNQKRFNR NGSNFNMKQN KSNPNDSISL SVVESTKKQD
TENELESNIE TKENRSTDIS IENTTSSKDS NTNSF
