FSLD_DICDI
ID FSLD_DICDI Reviewed; 634 AA.
AC Q55DT7;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=Frizzled and smoothened-like protein D;
DE Flags: Precursor;
GN Name=fslD; ORFNames=DDB_G0269528;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72114.1; -; Genomic_DNA.
DR RefSeq; XP_646044.1; XM_640952.1.
DR AlphaFoldDB; Q55DT7; -.
DR PaxDb; Q55DT7; -.
DR EnsemblProtists; EAL72114; EAL72114; DDB_G0269528.
DR GeneID; 8616991; -.
DR KEGG; ddi:DDB_G0269528; -.
DR dictyBase; DDB_G0269528; fslD.
DR eggNOG; ENOG502T166; Eukaryota.
DR HOGENOM; CLU_030318_0_0_1; -.
DR InParanoid; Q55DT7; -.
DR PhylomeDB; Q55DT7; -.
DR PRO; PR:Q55DT7; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Coiled coil; Glycoprotein; Membrane; Receptor; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..634
FT /note="Frizzled and smoothened-like protein D"
FT /id="PRO_0000371366"
FT TOPO_DOM 22..257
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..287
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..335
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..356
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 357..368
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..389
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 390..410
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 411..431
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 432..454
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 455..475
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 476..513
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 514..534
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 535..634
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 34..178
FT /note="FZ"
FT REGION 560..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 126
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 168
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 215
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 243
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 254
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 634 AA; 70779 MW; 831C6B576661949A CRC64;
MINKFKFYLI FLKLILILVN CQNSLNDYGF GIVDESSICT SYIGDELCKN RLSNSESIYT
TPGGGGGGGI DKLSQISTLP ILQKGFQSLT FSQGICKDLN FIEFGMCDSA LSPCIETTPK
ITPGYNISLP QRVCKSVCER MLIGCPQLAI QIDCSISFLF PKIGTFYNLT KYGYTANGGM
YMVPCIDTEI NYEKNKVQEN VGFLESCPYP LLLKNSTDPQ YAEKRGYTYL TPTNCVLPCP
IPNYTKRQMD SVINMSKAMS SISFVLSLFN VITFGLLIKK KSKYNVCIAL MAIGSSFIYL
SDIINYGVGI EKQLCPEPGR VATQRVDSLC GFTGSIFHIG ITLCVLWSMT MGIVLYSKIK
QFKLPNFRYF LIGNLSFTVV TLIILASAKK FQGGNGFLEC WMRDRWYVVA IFWIPCGIAL
LLGVLSICGV IFEIYKISKN VSLKDSKVVI RELKPFVLVV TVSASLIYLF VFYFDSESKY
DFYKKGVEDY ILCLLTSENP LDECYTVGPN FNSYFMFYFL IRFFGILFFG IFGTSEIARN
AWTESFFVTK IKSKISITTV SSSTRGGGGD TSGIKSSSSS SNSGVCNNNN STRKNYGDDF
NSKNLSQPDN TIITNNNNND NNNKMEIELD SIDI
