FSLH_DICDI
ID FSLH_DICDI Reviewed; 621 AA.
AC Q556C6;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Frizzled and smoothened-like protein H;
DE Flags: Precursor;
GN Name=fslH; ORFNames=DDB_G0274773;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
RN [4]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=18590548; DOI=10.1186/1471-2180-8-109;
RA Carilla-Latorre S., Calvo-Garrido J., Bloomfield G., Skelton J., Kay R.R.,
RA Ivens A., Martinez J.L., Escalante R.;
RT "Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common
RT and specific effects from PAO1 and PA14 strains.";
RL BMC Microbiol. 8:109-109(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Up-regulated by P.aeruginosa, PAO1 strain and down-regulated
CC by P.aeruginosa, PA14 strain infection. {ECO:0000269|PubMed:18590548}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000012; EAL70279.1; -; Genomic_DNA.
DR RefSeq; XP_643884.1; XM_638792.1.
DR AlphaFoldDB; Q556C6; -.
DR PaxDb; Q556C6; -.
DR EnsemblProtists; EAL70279; EAL70279; DDB_G0274773.
DR GeneID; 8619310; -.
DR KEGG; ddi:DDB_G0274773; -.
DR dictyBase; DDB_G0274773; fslH.
DR eggNOG; ENOG502RBXU; Eukaryota.
DR HOGENOM; CLU_030318_0_0_1; -.
DR InParanoid; Q556C6; -.
DR OMA; KCEKYIG; -.
DR PhylomeDB; Q556C6; -.
DR PRO; PR:Q556C6; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.10.2000.10; -; 1.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..621
FT /note="Frizzled and smoothened-like protein H"
FT /id="PRO_0000371370"
FT TOPO_DOM 22..246
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..277
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..318
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 340..359
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..380
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 381..400
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 422..464
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 465..485
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 486..520
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 521..541
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 542..621
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 27..166
FT /note="FZ"
FT REGION 575..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 60
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 107
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 163
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 176
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 206
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 32..103
FT /evidence="ECO:0000250"
FT DISULFID 46..96
FT /evidence="ECO:0000250"
SQ SEQUENCE 621 AA; 69274 MW; 32C935055D1F1EE2 CRC64;
MNLKFYNLIF FISFLICCIH GQRYLPVEGG KCEKYIGDGD SGKRICNGYL ANPDSVYVHN
KTQQETLKDL RSLINLLELN NPSKECINPS NYKIMCAMMF PECIEINGTN IVKPITLPIY
TCNSFCKEAL VTCSVPNTIA SCDGGTNLPI QLPYTPIEWV KYNLTIYGGV DDYRVNCTDP
TLISDSGSSS EIEVGCVEPL IKRPTNDTKG DLEKGYFYVN SQCVINCPVT GMHPKSVWNQ
IFKINDVLSS ISLACTLILL FTFGILNPKL NRFDKKNLFF IAGVFGMSVS GVLIAANGSE
KTVCPTPERY AVNTDRVCVA SGFLVHFSAL FAILWWTIGL ADVYYGIKFV GKKIKIKVRY
YLLATLTISL AFTLVPLGTG QYQAGLSNVM CFLKDEIYQS MTFFVPLGIC LTMGTILMIL
VMREIYVIVK SNSTSSSFSS SSSKSKSKSK SSDSISYLKL QVKPMLNIIL FYFTFLYLFL
FVRVINSRYQ EYEDSAIPYM LCLAKGGGDS CRLKGPSAGS LGYFAYCLRI YGIYLFIISF
LSSRTIKIWK ESIILNNAFV TPIIKFIDSS FSNRFSSSKN TSTTQNSTLN NTESDTSKRG
NSSAVSINLE SRNYNTDDDD L
