FSLK_DICDI
ID FSLK_DICDI Reviewed; 580 AA.
AC Q54PA5;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Frizzled and smoothened-like protein K;
DE Flags: Precursor;
GN Name=fslK; ORFNames=DDB_G0284729;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
RN [3]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=18559084; DOI=10.1186/1471-2164-9-291;
RA Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B.,
RA Skelton J., Ivens A., Bozzaro S.;
RT "Genome-wide transcriptional changes induced by phagocytosis or growth on
RT bacteria in Dictyostelium.";
RL BMC Genomics 9:291-291(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Down-regulated by phagocytic stimuli.
CC {ECO:0000269|PubMed:18559084}.
CC -!- DOMAIN: Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl
CC (Disheveled) family members and is involved in the activation of the
CC Wnt/beta-catenin signaling pathway. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000070; EAL65134.1; -; Genomic_DNA.
DR RefSeq; XP_638470.1; XM_633378.1.
DR AlphaFoldDB; Q54PA5; -.
DR SMR; Q54PA5; -.
DR STRING; 44689.DDB0231861; -.
DR PaxDb; Q54PA5; -.
DR EnsemblProtists; EAL65134; EAL65134; DDB_G0284729.
DR GeneID; 8624721; -.
DR KEGG; ddi:DDB_G0284729; -.
DR dictyBase; DDB_G0284729; fslK.
DR eggNOG; ENOG502R9ZP; Eukaryota.
DR HOGENOM; CLU_030318_0_0_1; -.
DR InParanoid; Q54PA5; -.
DR OMA; YLFGYNF; -.
DR PhylomeDB; Q54PA5; -.
DR PRO; PR:Q54PA5; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..580
FT /note="Frizzled and smoothened-like protein K"
FT /id="PRO_0000371372"
FT TOPO_DOM 19..236
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..264
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..308
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 330..349
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 350..370
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 371..391
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 392..412
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 413..434
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 435..455
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 456..490
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 491..511
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 512..580
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 25..154
FT /note="FZ"
FT REGION 542..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 514..519
FT /note="Lys-Thr-X-X-X-Trp motif, mediates interaction with
FT the PDZ domain of Dvl family members"
FT /evidence="ECO:0000250"
FT COMPBIAS 542..568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 52
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 149
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 170
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 186
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 580 AA; 65458 MW; 407DDC3898C207F8 CRC64;
MRVLFILFLF YFYTYTEAQQ YYPIDPTGKC EQYIGDSVIT PCNSIYVSST ANQSTAMLSL
NLYFSLLGGS SASCQNAYTF ATLCSTYLPE CEIFIDNSTN KEIAMPKRVC LDTCNSVSKN
CQITSYFDCN QLEPISKLPL FPKESSDYNL TTYGGELNYR LDCYDPPKSN ETTVIGYCPF
PLVFRNRTIV GKGSDSLDNS ENYGYTYVSE DSYCTIPCPA PIFSEKQWDN IFDTSDAISL
VSLLCSVYLF ITYMVINPKR NKYDYFFSFF VLSIILMSIA GTIGFSVGGT RKLLCPEINR
RGVYTDPAVA AAGWIFQFAI INAILWFSIN SFELWFQIKF IKRKLHLIKF YILAVLVISI
ALSVPLSAIG EFNAGLGNFV VWIESGKYQN WFFWGPLGIV LTVGTTFIGL VIWEIYKIVS
STNKSDFFKL QLKPLMNMLL IYLTFVYLFG YNFYIHNSLN GFYGSSEEFK NCIISTDGKD
CRIQGPPYSS ILMFVFCLRI YGVYCIALYG FSPKTRSIWS NSIVFNNSMA NKLKTLYISS
GTTKGGTSST DIKMSTNNNS NMDSGGGKSS SMEPDEIILR
