FSLM_DICDI
ID FSLM_DICDI Reviewed; 623 AA.
AC Q556N7; Q86K15;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 2.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Frizzled and smoothened-like protein M;
DE Flags: Precursor;
GN Name=fslM-1; ORFNames=DDB_G0273035;
GN and
GN Name=fslM-2; ORFNames=DDB_G0274033;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000305}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL70450.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAL71155.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AAFI02000011; EAL70450.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AAFI02000009; EAL71155.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_644375.1; XM_639283.1.
DR RefSeq; XP_645038.1; XM_639946.1.
DR AlphaFoldDB; Q556N7; -.
DR PaxDb; Q556N7; -.
DR EnsemblProtists; EAL70450; EAL70450; DDB_G0274033.
DR EnsemblProtists; EAL71155; EAL71155; DDB_G0273035.
DR GeneID; 8618715; -.
DR GeneID; 8619261; -.
DR KEGG; ddi:DDB_G0273035; -.
DR KEGG; ddi:DDB_G0274033; -.
DR dictyBase; DDB_G0273035; fslM-1.
DR dictyBase; DDB_G0274033; fslM-2.
DR eggNOG; ENOG502RF31; Eukaryota.
DR InParanoid; Q556N7; -.
DR PRO; PR:Q556N7; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.10.2000.10; -; 1.
DR InterPro; IPR036790; Frizzled_dom_sf.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..623
FT /note="Frizzled and smoothened-like protein M"
FT /id="PRO_0000371374"
FT TOPO_DOM 19..243
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..273
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..317
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 339..354
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 376..397
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 419..439
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 461..494
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 495..515
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 516..623
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 25..163
FT /note="FZ"
FT REGION 552..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 106
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 109
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 154
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 169
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 199
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 239
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 463
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 30..100
FT /evidence="ECO:0000250"
FT DISULFID 42..93
FT /evidence="ECO:0000250"
SQ SEQUENCE 623 AA; 70199 MW; 9C282ACBBB271E42 CRC64;
MKSIFIIIFI LYVFQVNSQT IYPIDPSGKC EQYIGDTPSS PCSKFLNNLD SIYVSSNATQ
QNAMKKLDEY FGILGAIGTS GCKSDSLTYK TLCSIYLPGC ESFTNNQTNI TIAIPKRICY
NTCNNVTTKC GVPKFYFSCD QIEPVSGLPM FPLNYSEFNL TNYDVGNPNY TVQCYGPLSD
NTMVNLDSSY CPPPLFYHNS TDHDADYDRG YLFVSETSNC VVPNPVPLYT NEQWDQLYNL
SNTLAVLSTF GSLYLLVTFI ILNPKVTSFD RMYGFFNGSV FMMSLSGVIL FIAGGPRALI
KDGGARISVF EDPLCSSTGF IFQLFAINAI LFWAYMGFDL WWRVKYITKP LNIQKYYVPI
AFTISFIFSV IPLATKNYRM VRGNIHCWVH KAVLQNTLFF GPLGLTLTIS TGFIGLVIYE
IYKIVKATGR GGIMKLEIKP ILNIVLIYFS FVYIFAFNFH NDNNSKNTYG SIDEFFQCTL
ESDDPSKCTV GGPSIGSLGY FIYCIRIYGI YCFFLQGLNE RAFKIWKRSI VFNNRFILFI
KVKLFSMDNN SPSESGNSST TAGTSTTINN SNINKKNNNS KPTLSTMDSN AFSKNNDSDS
DFDDYDPYHK KQNDIEIGSV NIK
