FSLN_DICDI
ID FSLN_DICDI Reviewed; 611 AA.
AC Q55CY2;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Frizzled and smoothened-like protein N;
DE Flags: Precursor;
GN Name=fslN; ORFNames=DDB_G0270672;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72686.1; -; Genomic_DNA.
DR RefSeq; XP_646349.1; XM_641257.1.
DR AlphaFoldDB; Q55CY2; -.
DR PaxDb; Q55CY2; -.
DR EnsemblProtists; EAL72686; EAL72686; DDB_G0270672.
DR GeneID; 8617304; -.
DR KEGG; ddi:DDB_G0270672; -.
DR dictyBase; DDB_G0270672; fslN.
DR eggNOG; ENOG502RBR8; Eukaryota.
DR HOGENOM; CLU_447205_0_0_1; -.
DR InParanoid; Q55CY2; -.
DR OMA; ASENDSC; -.
DR PhylomeDB; Q55CY2; -.
DR PRO; PR:Q55CY2; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.10.2000.10; -; 1.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR SUPFAM; SSF63501; SSF63501; 1.
DR PROSITE; PS50038; FZ; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..611
FT /note="Frizzled and smoothened-like protein N"
FT /id="PRO_0000371375"
FT TOPO_DOM 25..230
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252..258
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..302
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 324..338
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 360..380
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 402..430
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 452..491
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 492..512
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 513..611
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 26..187
FT /note="FZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT REGION 538..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 63
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 140
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 156
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 165
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 179
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 31..98
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT DISULFID 40..91
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT DISULFID 82..125
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT DISULFID 114..184
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT DISULFID 118..170
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 611 AA; 69796 MW; 72F4D74993CC2203 CRC64;
MKMKMKILLI FLKFFFLKKL FVNSLDIGSK CEILNPISMC SNYLGYKNIY LPYGYTQEII
EANVTATLTN PMGFSAIPDL ICKENIIKLF CISTYRECNS NINGISFPLP SNPCQKNCFK
VLETCVPFLS FFQGFSCQQN DTDGKDLYPI TENYYNLTSY GGSSNQSIQC SNPNQGSTNT
TVSCVYPLVY VSTDDIKNGE KFHEVMPNCV LPCPLYVYTD KQYDAKFYTE VVFYCVSATI
AVYLILTFGL IQNKITHRSW IIIYLGFTVL ALCASYATQQ YGNGDFRCSS QPGRYRSSQD
GNCMLTGFFF QMGGLGTIFM LSLYSFDFFL TINMKTNKYF LQTSIGVWAL IFFFALLPIK
HYESTIDSAG CWIGEYNNRF WLYFCFYIPA YIVTFLMVIF ITSSIYKVFK MTVLFKSIND
RRILFLNLRS VTFLLVILFC ISFTSMYPLY VSYNGEVFYD AIEKWVYCLL EKGNDQCPRI
QFSRFGLRYM NAFCMSIIGI LLLFGLGIDP HIATIYRESE RFNYLLHLVG IKWGNTPVPS
KKSSTSSNSS GSSGEKTRET RKTRGQSISL KKIDQSNSNS NSNEIESSSI DKQPSSILNN
HNNNDDKQSQ A
