FSLQ_DICDI
ID FSLQ_DICDI Reviewed; 578 AA.
AC Q1ZXE4;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Frizzled and smoothened-like protein Q;
DE Flags: Precursor;
GN Name=fslQ; ORFNames=DDB_G0286609;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000089; EAS66849.1; -; Genomic_DNA.
DR RefSeq; XP_001134532.1; XM_001134532.1.
DR AlphaFoldDB; Q1ZXE4; -.
DR SMR; Q1ZXE4; -.
DR PaxDb; Q1ZXE4; -.
DR EnsemblProtists; EAS66849; EAS66849; DDB_G0286609.
DR GeneID; 8625704; -.
DR KEGG; ddi:DDB_G0286609; -.
DR dictyBase; DDB_G0286609; fslQ.
DR eggNOG; ENOG502RGJ6; Eukaryota.
DR HOGENOM; CLU_447205_0_0_1; -.
DR InParanoid; Q1ZXE4; -.
DR OMA; FYLEERI; -.
DR PhylomeDB; Q1ZXE4; -.
DR PRO; PR:Q1ZXE4; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.10.2000.10; -; 1.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR SUPFAM; SSF63501; SSF63501; 1.
DR PROSITE; PS50038; FZ; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..578
FT /note="Frizzled and smoothened-like protein Q"
FT /id="PRO_0000371378"
FT TOPO_DOM 24..233
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..261
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..305
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 327..341
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 363..388
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 389..409
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 410..422
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 423..443
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 444..490
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 491..511
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 512..578
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 27..157
FT /note="FZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT REGION 544..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 46
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 64
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 99
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 144
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 155
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 181
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 233
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 289
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 32..95
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT DISULFID 41..88
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT DISULFID 79..128
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT DISULFID 121..141
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 578 AA; 65439 MW; B2D21815B36980B9 CRC64;
MKNSFLINIL IIYYLFIILF VNSQDLKLGG SCELIDSNSP CFSKLNYTNF YLQPGDSITQ
LNKNVSDIIR MLEFTTPECK PNAINIMCLK SYPKCETYNE TLSNNTNIIF NLPSLPCNSI
CLKAETPCKI FIDNFIKDLS CNSNFSNGAP MFPINSTDYE FKESGNFNFN VECNDNIIYD
NSSSVINCPA PLLNSKDHVI PGKTTYYYIT DSCILDCPFE IYPGKTKILD RTNYTLTSIS
FITCIFMILT FGVLPNKITH RMESILSFAC GGCITALSLF IQSRQDNFNC SSDPGRFKSQ
SDYLCLLTGL IFQFGAITSI FWSPMIAYDF YITSTLGKIR KFGLYRIVLW SFIFVLTALP
AFGGKYSATV ATNCWINSDD GSAWQYVSFY IPSWCAMGLI CLFSILSVIN VSKMYIQTPN
NRILFFNIKI LITLLLFLFV LTFASSLKFY MEERMDTYFD AIAVWVECIG KGDPSQCELH
APGYDLKALN IVVIGILGFT VFIGYGLDPI VIHIWMESKK FQWVLKKCRL DKIIKLNNSI
NNSNNNNNET ASTSSGNERK QTTVKMSNLK STEINQQP
