ID   FSPM_SOLLC              Reviewed;          96 AA.
AC   P14903;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Fruit-specific protein;
GN   Name=2A11;
OS   Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC   Solanum subgen. Lycopersicon.
OX   NCBI_TaxID=4081;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=cv. UC82B; TISSUE=Fruit;
RX   PubMed=2491680; DOI=10.1007/bf00016019;
RA   Pear J.R., Ridge N.P., Rasmussen R., Rose R.E., Houck C.M.;
RT   "Isolation and characterization of a fruit-specific cDNA and the
RT   corresponding genomic clone from tomato.";
RL   Plant Mol. Biol. 13:639-651(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=cv. VFNT Cherry;
RA   van Haaren M.J.J., Houck C.M.;
RT   "The fruit specific expression of the tomato gene 2A11 is strongly
RT   influenced by far upstream located cis-acting elements.";
RL   Submitted (MAY-1992) to the EMBL/GenBank/DDBJ databases.
CC   -!- TISSUE SPECIFICITY: Fruit specific.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- MISCELLANEOUS: This protein is sulfur-rich (Met and Cys rich).
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DR   EMBL; X13743; CAA32007.1; -; Genomic_DNA.
DR   EMBL; M21775; AAA34129.1; -; mRNA.
DR   EMBL; M21776; AAA34130.1; -; mRNA.
DR   EMBL; M87659; AAA34165.1; -; Genomic_DNA.
DR   PIR; S07603; S07603.
DR   RefSeq; NP_001234762.1; NM_001247833.2.
DR   PDB; 2HLG; NMR; -; A=58-96.
DR   PDBsum; 2HLG; -.
DR   AlphaFoldDB; P14903; -.
DR   SMR; P14903; -.
DR   STRING; 4081.Solyc07g049140.2.1; -.
DR   PaxDb; P14903; -.
DR   PRIDE; P14903; -.
DR   ProMEX; P14903; -.
DR   EnsemblPlants; Solyc07g049140.3.1; Solyc07g049140.3.1; Solyc07g049140.3.
DR   GeneID; 543980; -.
DR   Gramene; Solyc07g049140.3.1; Solyc07g049140.3.1; Solyc07g049140.3.
DR   KEGG; sly:543980; -.
DR   HOGENOM; CLU_188695_0_0_1; -.
DR   InParanoid; P14903; -.
DR   OMA; AAKNSEM; -.
DR   OrthoDB; 1487400at2759; -.
DR   PhylomeDB; P14903; -.
DR   EvolutionaryTrace; P14903; -.
DR   Proteomes; UP000004994; Chromosome 7.
DR   InterPro; IPR004231; COpept_A_inh-like.
DR   Pfam; PF02977; CarbpepA_inh; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Disulfide bond; Knottin; Reference proteome.
FT   CHAIN           1..96
FT                   /note="Fruit-specific protein"
FT                   /id="PRO_0000087357"
FT   DISULFID        59..75
FT                   /evidence="ECO:0000250"
FT   DISULFID        63..78
FT                   /evidence="ECO:0000250"
FT   DISULFID        69..92
FT                   /evidence="ECO:0000250"
FT   STRAND          64..66
FT                   /evidence="ECO:0007829|PDB:2HLG"
FT   HELIX           67..69
FT                   /evidence="ECO:0007829|PDB:2HLG"
FT   STRAND          70..74
FT                   /evidence="ECO:0007829|PDB:2HLG"
FT   STRAND          77..82
FT                   /evidence="ECO:0007829|PDB:2HLG"
FT   STRAND          88..94
FT                   /evidence="ECO:0007829|PDB:2HLG"
SQ   SEQUENCE   96 AA;  10699 MW;  F6B2BF5D0A955FA6 CRC64;
     MAAKNSEMKF AIFFVVLLTT TLVDMSGISK MQVMALRDIP PQETLLKMKL LPTNILGLCN
     EPCSSNSDCI GITLCQFCKE KTDQYGLTYR TCNLLP