FSQA_ASPFU
ID FSQA_ASPFU Reviewed; 525 AA.
AC Q4WD42;
DT 15-FEB-2017, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=C6 finger transcription factor fsqA {ECO:0000303|PubMed:27065235};
DE AltName: Full=Fumipyrrole biosynthesis protein R {ECO:0000303|PubMed:25582336};
DE AltName: Full=Fumisoquins biosynthesis protein A {ECO:0000303|PubMed:27065235};
GN Name=fsqA {ECO:0000303|PubMed:27065235};
GN Synonyms=fmpR {ECO:0000303|PubMed:25582336}; ORFNames=AFUA_6G03430;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
RN [2]
RP INDUCTION, FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=25582336; DOI=10.1111/mmi.12926;
RA Macheleidt J., Scherlach K., Neuwirth T., Schmidt-Heck W., Strassburger M.,
RA Spraker J., Baccile J.A., Schroeder F.C., Keller N.P., Hertweck C.,
RA Heinekamp T., Brakhage A.A.;
RT "Transcriptome analysis of cyclic AMP-dependent protein kinase A-regulated
RT genes reveals the production of the novel natural compound fumipyrrole by
RT Aspergillus fumigatus.";
RL Mol. Microbiol. 96:148-162(2015).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=27065235; DOI=10.1038/nchembio.2061;
RA Baccile J.A., Spraker J.E., Le H.H., Brandenburger E., Gomez C., Bok J.W.,
RA Macheleidt J., Brakhage A.A., Hoffmeister D., Keller N.P., Schroeder F.C.;
RT "Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus
RT fumigatus.";
RL Nat. Chem. Biol. 12:419-424(2016).
CC -!- FUNCTION: Transcription factor that regulates the expression of the
CC gene cluster that mediates the biosynthesis of the isoquinoline
CC alkaloids fumisoquin A, fumisoquin B and fumisoquin C; as well as small
CC amounts of fumipyrrole as a shunt metabolite (PubMed:25582336,
CC PubMed:27065235). The products of the cluster lead to a brown
CC coloration and are important for growth and conidiation
CC (PubMed:25582336). {ECO:0000269|PubMed:25582336,
CC ECO:0000269|PubMed:27065235}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC -!- INDUCTION: Expression is induced by the cAMP-dependent protein kinase A
CC signaling pathway (PubMed:25582336). {ECO:0000269|PubMed:25582336}.
CC -!- DISRUPTION PHENOTYPE: Leads to reduced growth and sporulation, but does
CC not affect virulence in infected mice (PubMed:25582336). Impairs the
CC production of isoquinolines (PubMed:27065235).
CC {ECO:0000269|PubMed:25582336, ECO:0000269|PubMed:27065235}.
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DR EMBL; AAHF01000012; EAL85696.1; -; Genomic_DNA.
DR RefSeq; XP_747734.1; XM_742641.1.
DR AlphaFoldDB; Q4WD42; -.
DR STRING; 746128.CADAFUBP00009220; -.
DR EnsemblFungi; EAL85696; EAL85696; AFUA_6G03430.
DR GeneID; 3505181; -.
DR KEGG; afm:AFUA_6G03430; -.
DR VEuPathDB; FungiDB:Afu6g03430; -.
DR eggNOG; ENOG502SYRD; Eukaryota.
DR HOGENOM; CLU_605645_0_0_1; -.
DR InParanoid; Q4WD42; -.
DR OMA; YILQAYE; -.
DR OrthoDB; 1576792at2759; -.
DR Proteomes; UP000002530; Chromosome 6.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0008152; P:metabolic process; IEA:UniProt.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..525
FT /note="C6 finger transcription factor fsqA"
FT /id="PRO_0000438868"
FT DNA_BIND 12..53
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 80..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 525 AA; 58058 MW; B13101FE73A0C7F0 CRC64;
MMDDKHGRYG ACDRCRGQKL RCVGAGKPIP NSSSRLLRNE IPCDRCRRAK VECYSVRPAP
RRAASNVKEQ MIATQAASER SSSLAYHTSG PVVSPPNSLV TAASKPHPNS LSFNHPRSDA
VAAPGGLQTR RQSRDTDSLG DMPSMPHEWM AYLHDHKMDD RQGLGMETPP LIESDLNLSR
DPAMDSMHEH NMMMELIHQD HQEEWNSGPP ELEAYPDPIV PPNPAPLKAR KLTSPDCDDY
PYGHTRRSSH TPTQPPEPAG RSCIQELAQF NEMLLRDKCS LEDTSARRGY KDSWLSIGRT
LHHCQQFFSI LKRIKYSRPD SQLSADRARS QWSSLPEGTS LADGAPTDSP QARRSLARGA
TPCSSSLARS SSTSSAASTS YLGLSTLLSI LFCYTYILQA YEDILTSILH AVTRPTPTIP
PTLSGLRIDG FQLDGHHTLQ LECLLHVSYN LLEKIENILF GSAGPEELSN PVKYGILGDK
LSAGLIDALF EHNETNGLLH CQGKREVAAK RLIREIQAAL KQLDL
