ID   FSR6_GIBF5              Reviewed;         338 AA.
AC   S0DW94; G8C424;
DT   25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2013, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Fusarubin cluster-specific transcription factor fsr6 {ECO:0000303|PubMed:22492438};
DE   AltName: Full=Fusarubin biosynthesis cluster protein 6 {ECO:0000303|PubMed:22492438};
GN   Name=fsr6 {ECO:0000303|PubMed:22492438}; ORFNames=FFUJ_03989;
OS   Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae
OS   and foot rot disease fungus) (Fusarium fujikuroi).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium fujikuroi species complex.
OX   NCBI_TaxID=1279085;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION, AND DISRUPTION
RP   PHENOTYPE.
RC   STRAIN=CBS 195.34 / IMI 58289 / NRRL A-6831;
RX   PubMed=22492438; DOI=10.1128/aem.00823-12;
RA   Studt L., Wiemann P., Kleigrewe K., Humpf H.U., Tudzynski B.;
RT   "Biosynthesis of fusarubins accounts for pigmentation of Fusarium fujikuroi
RT   perithecia.";
RL   Appl. Environ. Microbiol. 78:4468-4480(2012).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND FUNCTION.
RC   STRAIN=CBS 195.34 / IMI 58289 / NRRL A-6831;
RX   PubMed=23825955; DOI=10.1371/journal.ppat.1003475;
RA   Wiemann P., Sieber C.M.K., von Bargen K.W., Studt L., Niehaus E.-M.,
RA   Espino J.J., Huss K., Michielse C.B., Albermann S., Wagner D.,
RA   Bergner S.V., Connolly L.R., Fischer A., Reuter G., Kleigrewe K., Bald T.,
RA   Wingfield B.D., Ophir R., Freeman S., Hippler M., Smith K.M., Brown D.W.,
RA   Proctor R.H., Muensterkoetter M., Freitag M., Humpf H.-U., Gueldener U.,
RA   Tudzynski B.;
RT   "Deciphering the cryptic genome: genome-wide analyses of the rice pathogen
RT   Fusarium fujikuroi reveal complex regulation of secondary metabolism and
RT   novel metabolites.";
RL   PLoS Pathog. 9:E1003475-E1003475(2013).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis of fusarubins, highly
CC       pigmented naphthoquinones responsible for the coloration of the
CC       fruiting bodies (PubMed:22492438, PubMed:23825955).
CC       {ECO:0000305|PubMed:22492438, ECO:0000305|PubMed:23825955}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- INDUCTION: Expression is induced in presence of sodium nitrate, and
CC       repressed by glutamine (PubMed:22492438).
CC       {ECO:0000269|PubMed:22492438}.
CC   -!- DISRUPTION PHENOTYPE: Impairs the red pigmentation due to the
CC       production of fusarubin (PubMed:22492438). Results in complete down-
CC       regulation of the other five FSR genes (PubMed:22492438).
CC       {ECO:0000269|PubMed:22492438}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HE613440; CCE67075.1; -; Genomic_DNA.
DR   EMBL; HF679024; CCT64758.1; -; Genomic_DNA.
DR   AlphaFoldDB; S0DW94; -.
DR   EnsemblFungi; CCT64758; CCT64758; FFUJ_03989.
DR   EnsemblFungi; KLP16370; KLP16370; LW94_5853.
DR   VEuPathDB; FungiDB:FFUJ_03989; -.
DR   Proteomes; UP000016800; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045122; P:aflatoxin biosynthetic process; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR013700; AflR.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF08493; AflR; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..338
FT                   /note="Fusarubin cluster-specific transcription factor
FT                   fsr6"
FT                   /id="PRO_0000442029"
FT   DNA_BIND        16..44
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
SQ   SEQUENCE   338 AA;  37390 MW;  74F36A11B2721F41 CRC64;
     MSETRSAKPV RLRLACDACT TAKVRCSRTH PCERCEDNGQ AKECCYSASR RHGKRARQRQ
     SAQDSSSSSL TTQFTNAWDD YSTYSAGDLE MLDSWASRSV DVTVDFDDGN GISWVDPWKS
     LGFVSDTTAS QSSGMVSPDL SLSTGPILSI KAPEPTAMHS HDCEALALKV LRSLQCNTNT
     DQSICKSSPI PQKQTFSTPS IDTVLSVNKA ALTNLIPLLK CHCARNPHIA MLHSAILSKV
     IFWYRVAVTA RYHADGVELR PMKIQLGMLD LDDEDQATLQ RTVVLRELRK AEKVMETFDS
     FAGGDDGGLN WHVVAVRNMR EELQGIIQKI KKCQGELM