ID   FSRB_ENTFO              Reviewed;         242 AA.
AC   F2MNH8; Q833V5; Q9RQG4;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Protein FsrB;
DE   AltName: Full=AgrBfs;
GN   Name=fsrB; OrderedLocusNames=OG1RF_11528;
OS   Enterococcus faecalis (strain ATCC 47077 / OG1RF).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=474186;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=ATCC 47077 / OG1RF;
RX   PubMed=10768947; DOI=10.1128/iai.68.5.2579-2586.2000;
RA   Qin X., Singh K.V., Weinstock G.M., Murray B.E.;
RT   "Effects of Enterococcus faecalis fsr genes on production of gelatinase and
RT   a serine protease and virulence.";
RL   Infect. Immun. 68:2579-2586(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 47077 / OG1RF;
RX   PubMed=18611278; DOI=10.1186/gb-2008-9-7-r110;
RA   Bourgogne A., Garsin D.A., Qin X., Singh K.V., Sillanpaa J.,
RA   Yerrapragada S., Ding Y., Dugan-Rocha S., Buhay C., Shen H., Chen G.,
RA   Williams G., Muzny D., Maadani A., Fox K.A., Gioia J., Chen L., Shang Y.,
RA   Arias C.A., Nallapareddy S.R., Zhao M., Prakash V.P., Chowdhury S.,
RA   Jiang H., Gibbs R.A., Murray B.E., Highlander S.K., Weinstock G.M.;
RT   "Large scale variation in Enterococcus faecalis illustrated by the genome
RT   analysis of strain OG1RF.";
RL   Genome Biol. 9:R110.1-R110.16(2008).
CC   -!- FUNCTION: May be involved in the proteolytic processing of a quorum
CC       sensing system signal molecule precursor required for the regulation of
CC       the virulence genes for gelatinase (gelE) and a serine protease (sprE).
CC       {ECO:0000269|PubMed:10768947}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the AgrB family. {ECO:0000305}.
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DR   EMBL; AF108141; AAF14219.1; -; Genomic_DNA.
DR   EMBL; CP002621; AEA94215.1; -; Genomic_DNA.
DR   RefSeq; WP_002377181.1; NZ_CP025020.1.
DR   AlphaFoldDB; F2MNH8; -.
DR   MEROPS; C75.002; -.
DR   GeneID; 60894108; -.
DR   KEGG; efi:OG1RF_11528; -.
DR   HOGENOM; CLU_1145793_0_0_9; -.
DR   OMA; MKFAIVY; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00784; AgrB; 1.
DR   InterPro; IPR006741; AgrB.
DR   Pfam; PF04647; AgrB; 1.
DR   SMART; SM00793; AgrB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Protease; Quorum sensing;
KW   Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..242
FT                   /note="Protein FsrB"
FT                   /id="PRO_0000412114"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   242 AA;  27629 MW;  241012008C7E3CB5 CRC64;
     MLIDWILKNI MDMDQEDQSG KTQWTKYYLT VYFSGLFNFL MILILSVLFG TLSETFIVYV
     VLIFLRPVAG GWHAKTKWLC RLESIVIYVA IPFVLKNSSV SLPFIYKILL ICLLVVLFYW
     YAPQGTAIEP VQPSDLNVLK KQSLIRVCLL ILCSLFVKEK IASVILYGLV IQGLMILPVT
     KNLIEGSVFM KFGKKIIKNV IEKRVAKVSD GVGTKPRLNQ NSPNIFGQWM GQTEKPKKNI
     EK