FSR_ECOLI
ID FSR_ECOLI Reviewed; 406 AA.
AC P52067; Q2MBU8;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Fosmidomycin resistance protein;
GN Name=fsr; OrderedLocusNames=b0479, JW0468;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / DH5-alpha;
RX PubMed=8917080; DOI=10.1016/0378-1119(96)00128-x;
RA Fujisaki S., Ohnuma S., Horiuchi T., Takahashi I., Tsukui S., Nishimura Y.,
RA Nishino T., Kitabatake M., Inokuchi H.;
RT "Cloning of a gene from Escherichia coli that confers resistance to
RT fosmidomycin as a consequence of amplification.";
RL Gene 175:83-87(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RA Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT "Sequence of minutes 4-25 of Escherichia coli.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: Confers the resistance against fosmidomycin.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; D73370; BAA11120.1; -; Genomic_DNA.
DR EMBL; U82664; AAB40233.1; -; Genomic_DNA.
DR EMBL; U00096; AAC73581.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76258.1; -; Genomic_DNA.
DR PIR; JC5041; JC5041.
DR RefSeq; NP_415012.1; NC_000913.3.
DR RefSeq; WP_001251608.1; NZ_SSZK01000009.1.
DR AlphaFoldDB; P52067; -.
DR SMR; P52067; -.
DR BioGRID; 4260849; 16.
DR STRING; 511145.b0479; -.
DR TCDB; 2.A.1.35.1; the major facilitator superfamily (mfs).
DR PaxDb; P52067; -.
DR PRIDE; P52067; -.
DR EnsemblBacteria; AAC73581; AAC73581; b0479.
DR EnsemblBacteria; BAE76258; BAE76258; BAE76258.
DR GeneID; 66671219; -.
DR GeneID; 945119; -.
DR KEGG; ecj:JW0468; -.
DR KEGG; eco:b0479; -.
DR PATRIC; fig|1411691.4.peg.1797; -.
DR EchoBASE; EB3054; -.
DR eggNOG; COG2223; Bacteria.
DR HOGENOM; CLU_040537_2_0_6; -.
DR InParanoid; P52067; -.
DR OMA; YFYMASF; -.
DR PhylomeDB; P52067; -.
DR BioCyc; EcoCyc:FSR-MON; -.
DR BioCyc; MetaCyc:FSR-MON; -.
DR PRO; PR:P52067; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; ISM:EcoCyc.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IEP:EcoliWiki.
DR GO; GO:0046677; P:response to antibiotic; IMP:EcoCyc.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Antibiotic resistance; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..406
FT /note="Fosmidomycin resistance protein"
FT /id="PRO_0000084838"
FT TOPO_DOM 1..42
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 85..102
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..177
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 199..225
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247..266
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..294
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..319
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 320..340
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 341..353
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 375..378
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 400..406
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 406 AA; 43306 MW; E1FC88D0E3F471F3 CRC64;
MAMSEQPQPV AGAAASTTKA RTSFGILGAI SLSHLLNDMI QSLILAIYPL LQSEFSLTFM
QIGMITLTFQ LASSLLQPVV GYWTDKYPMP WSLPIGMCFT LSGLVLLALA GSFGAVLLAA
ALVGTGSSVF HPESSRVARM ASGGRHGLAQ SIFQVGGNFG SSLGPLLAAV IIAPYGKGNV
AWFVLAALLA IVVLAQISRW YSAQHRMNKG KPKATIINPL PRNKVVLAVS ILLILIFSKY
FYMASISSYY TFYLMQKFGL SIQNAQLHLF AFLFAVAAGT VIGGPVGDKI GRKYVIWGSI
LGVAPFTLIL PYASLHWTGV LTVIIGFILA SAFSAILVYA QELLPGRIGM VSGLFFGFAF
GMGGLGAAVL GLIADHTSIE LVYKICAFLP LLGMLTIFLP DNRHKD
