FSTL5_MOUSE
ID FSTL5_MOUSE Reviewed; 847 AA.
AC Q8BFR2; Q80TG3; Q8C4T3;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Follistatin-related protein 5;
DE AltName: Full=Follistatin-like protein 5;
DE AltName: Full=m-D/Bsp120I 1-2;
DE Flags: Precursor;
GN Name=Fstl5; Synonyms=Kiaa1263;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Kato A., Noda M.;
RT "Identification of m-D/Bsp120I 1-2.";
RL Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cecum, Cerebellum, and Corpora quadrigemina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 402-847.
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; AF374460; AAQ02778.1; -; mRNA.
DR EMBL; AK033652; BAC28408.1; -; mRNA.
DR EMBL; AK046070; BAC32590.1; -; mRNA.
DR EMBL; AK081152; BAC38146.1; -; mRNA.
DR EMBL; BC075640; AAH75640.1; -; mRNA.
DR EMBL; AK122482; BAC65764.1; -; mRNA.
DR CCDS; CCDS38455.1; -.
DR RefSeq; NP_001240648.1; NM_001253719.1.
DR RefSeq; NP_848788.2; NM_178673.4.
DR AlphaFoldDB; Q8BFR2; -.
DR STRING; 10090.ENSMUSP00000038506; -.
DR MEROPS; I01.977; -.
DR GlyGen; Q8BFR2; 2 sites.
DR iPTMnet; Q8BFR2; -.
DR PhosphoSitePlus; Q8BFR2; -.
DR MaxQB; Q8BFR2; -.
DR PaxDb; Q8BFR2; -.
DR PRIDE; Q8BFR2; -.
DR ProteomicsDB; 266876; -.
DR Antibodypedia; 28231; 98 antibodies from 18 providers.
DR Ensembl; ENSMUST00000038364; ENSMUSP00000038506; ENSMUSG00000034098.
DR Ensembl; ENSMUST00000160261; ENSMUSP00000125393; ENSMUSG00000034098.
DR GeneID; 213262; -.
DR KEGG; mmu:213262; -.
DR UCSC; uc008pnj.2; mouse.
DR CTD; 56884; -.
DR MGI; MGI:2442179; Fstl5.
DR VEuPathDB; HostDB:ENSMUSG00000034098; -.
DR eggNOG; ENOG502QPNV; Eukaryota.
DR GeneTree; ENSGT00940000156495; -.
DR HOGENOM; CLU_007849_1_0_1; -.
DR InParanoid; Q8BFR2; -.
DR OMA; KYGYVTH; -.
DR OrthoDB; 1065760at2759; -.
DR PhylomeDB; Q8BFR2; -.
DR TreeFam; TF350473; -.
DR BioGRID-ORCS; 213262; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Fstl5; mouse.
DR PRO; PR:Q8BFR2; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q8BFR2; protein.
DR Bgee; ENSMUSG00000034098; Expressed in olfactory epithelium and 99 other tissues.
DR ExpressionAtlas; Q8BFR2; baseline and differential.
DR Genevisible; Q8BFR2; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF07648; Kazal_2; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF100895; SSF100895; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 2: Evidence at transcript level;
KW Calcium; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Metal-binding; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..847
FT /note="Follistatin-related protein 5"
FT /id="PRO_0000010119"
FT DOMAIN 81..135
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DOMAIN 175..210
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 211..246
FT /note="EF-hand 2"
FT /evidence="ECO:0000305"
FT DOMAIN 250..338
FT /note="Ig-like 1"
FT DOMAIN 341..426
FT /note="Ig-like 2"
FT BINDING 188
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 190
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 192
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 199
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 226
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10142"
FT BINDING 228
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10142"
FT BINDING 230
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10142"
FT BINDING 232
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10142"
FT BINDING 237
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10142"
FT CARBOHYD 318
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 394
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 87..119
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 93..112
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 101..133
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 270..321
FT /evidence="ECO:0000250"
FT DISULFID 362..413
FT /evidence="ECO:0000250"
FT CONFLICT 183
FT /note="M -> R (in Ref. 2; BAC38146)"
FT /evidence="ECO:0000305"
FT CONFLICT 468
FT /note="T -> R (in Ref. 4; BAC65764)"
FT /evidence="ECO:0000305"
FT CONFLICT 840
FT /note="T -> I (in Ref. 4; BAC65764)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 847 AA; 95816 MW; F9F9D7BB62E2F14A CRC64;
MFRCWSAILI LGFIFLASEG RPTKESGYGL KSYQPLTRLR HKQEKSQESS RIKEFLIHDG
PFGSCENKYC GLGRHCVINR ETRHAECACM DLCKQHYKPV CGSDGEFYEN HCEVHRAACL
KKQKITIVHN EDCFFEGDNC MAIEYSKMKS MLLDLQNQKY ITQENENPNS DDISRKKPLV
DQMFKYFDAD SNGLVDINEL TQVIKQEELN KDLSDCTLYD LLKYDDFNAD KHLALEEFYR
AFQVIQLSLP EDQRVSITAA TVGQSAVLSC AIVGTLRPPI IWKRNNIVLN NLDLEDINDF
GDDGSLYITK VTTVHMGNYT CYADGYENVR QTHIFQVNVP PVIRVYPESQ AREPGVTASL
RCHAEGIPDP QLGWLKNGID ITPKLSKQLT LQANGSEVHI SNVRYEDTGA YTCIARNEAG
VDEDISSLFV EDSARKTLAN ILWREEGLGI GNMFYVFYED GIKVIQPTEC EFQRHIKPSE
KLLGYQDEVC PKAEEDEVQR CVWASAVNVK DKFIYVAQPT LDRILIVDVQ SQKVVQAVST
DPVPVKLHYD KSHDQVWVLS WGSMEKTSPT LQVITLASGN VPHHTIHTQP VGKQFDRVDD
FFIPTPTLII THMRFGFILH KDESALHKID LETMSYIKTI NLKDSRCIPL SLAYTHLGGY
YFISCKADIT GATPPQLVVD SVTDSIIGFN SDVTGTPYVS PDGHYLVSVN DVKGLVRVQY
ITIRGEILDA FDIHTNLHIS DLAFQPSFTE AHQYNIYGSS SQQTDVLFVE LSSGKVKMIK
SLKEPLKTED WPWSQKNRHI QGSGLFGQYL MTPSKDSLFI LDGRLNKLNC EITEVQKGNT
VVWVGDA
