FT105_SCHPO
ID FT105_SCHPO Reviewed; 925 AA.
AC O13776;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Ubp5-interacting protein ftp105;
DE AltName: Full=Down-regulated in multiple cancers 1 homolog 3;
DE AltName: Full=Hid-1 family protein ftp105;
GN Name=ftp105; ORFNames=SPAC17A5.16;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP FUNCTION.
RX PubMed=18684775; DOI=10.1093/toxsci/kfn153;
RA Kennedy P.J., Vashisht A.A., Hoe K.L., Kim D.U., Park H.O., Hayles J.,
RA Russell P.;
RT "A genome-wide screen of genes involved in cadmium tolerance in
RT Schizosaccharomyces pombe.";
RL Toxicol. Sci. 106:124-139(2008).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH UBP5, FUNCTION, AND
RP SUBCELLULAR LOCATION.
RX PubMed=20838651; DOI=10.1371/journal.pbio.1000471;
RA Kouranti I., McLean J.R., Feoktistova A., Liang P., Johnson A.E.,
RA Roberts-Galbraith R.H., Gould K.L.;
RT "A global census of fission yeast deubiquitinating enzyme localization and
RT interaction networks reveals distinct compartmentalization profiles and
RT overlapping functions in endocytosis and polarity.";
RL PLoS Biol. 8:708-716(2010).
CC -!- FUNCTION: Required for the localization of ubp5 to the Golgi apparatus.
CC Involved in detoxification of cadmium ion.
CC {ECO:0000269|PubMed:18684775, ECO:0000269|PubMed:20838651}.
CC -!- SUBUNIT: Interacts with ubp5. {ECO:0000269|PubMed:20838651}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Golgi
CC apparatus {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:20838651}.
CC -!- SIMILARITY: Belongs to the hid-1 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB11516.1; -; Genomic_DNA.
DR PIR; T37831; T37831.
DR RefSeq; NP_593484.1; NM_001018917.2.
DR AlphaFoldDB; O13776; -.
DR BioGRID; 278643; 91.
DR STRING; 4896.SPAC17A5.16.1; -.
DR iPTMnet; O13776; -.
DR MaxQB; O13776; -.
DR PaxDb; O13776; -.
DR PRIDE; O13776; -.
DR EnsemblFungi; SPAC17A5.16.1; SPAC17A5.16.1:pep; SPAC17A5.16.
DR GeneID; 2542168; -.
DR KEGG; spo:SPAC17A5.16; -.
DR PomBase; SPAC17A5.16; ftp105.
DR VEuPathDB; FungiDB:SPAC17A5.16; -.
DR eggNOG; KOG2226; Eukaryota.
DR HOGENOM; CLU_007392_0_0_1; -.
DR InParanoid; O13776; -.
DR OMA; VCPRPVC; -.
DR PhylomeDB; O13776; -.
DR PRO; PR:O13776; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR GO; GO:0005797; C:Golgi medial cisterna; IBA:GO_Central.
DR GO; GO:0000138; C:Golgi trans cisterna; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR InterPro; IPR026705; Hid-1/Ecm30.
DR PANTHER; PTHR21575; PTHR21575; 1.
DR Pfam; PF12722; Hid1; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Golgi apparatus; Reference proteome.
FT CHAIN 1..925
FT /note="Ubp5-interacting protein ftp105"
FT /id="PRO_0000116710"
FT REGION 650..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 925 AA; 104836 MW; 432E7B468699246F CRC64;
MGGQESKLAF QRGIARLASQ PDIPLDDEVW VSLWSVPESC PEVYDFFPPG LIREMRDHAF
VNLEKLLLVL TSRLFALKND KKFPNPETAP ASEALNCIRL LTRIIPFLNE KLDLEEWHQK
FWWSLRKKRN LPKENSELDL SNFQDDLDFE NSISQKNEFS QKSPSVPLSP VSTFPASSIS
LDASSDVSAA DVSVGGSSTI KEIGSIEETF THEKTLMEEL LDTVFRLLFC RGFTLPLSSP
EQYAYIIWEN GIGTTETQEK TTKELAFNRI EVLRLLLVLI SKRLYRSSEV ASHTLTYLTC
VANKQLILVF LYSLINTTLR LRPDSWKASY STLVPYNDSS IALSKLTSQI LLLFLDHTPH
ETTVEYFRQR LNLSPGAAIE NQYRLYFSRL QLQADYEFLV NELYRLLNAP VSAISAYISI
VQKPNIAFPE IILFLWQAIL YNKRFRAFLI TSPYATEFLT SIQFYALRYR EDNEHSGLVR
ICLFIVHYLS CEKVLCEKLN RNCMNAQSLM SSLGFSVPPM SYAEFLIISS FHISAVKRSP
FSSLSPVILL TICNIAPFVE NLSFVTCAKL MQLCSSLSSP RFLFRNPRNH LLLEYLLQAI
SSIVENKFSQ NPNLSYSIIR LQQVFLNLNS MKLPAVAQTK SQPLVALNSE GSSDFESKSS
DNTSLDGTPL QNTDFKKVAT VEDDSPFDEL DKFSSPFSSS SSRGGLSHIS SRNVSISVPT
VLQDVFSDSP LVLSRKLRGK IPENVSSSEL IKKCASNPFG KDLEIDSNLF APSNSWFNSW
HSRLELDSIL AIISQFSLPV YKKMNEELST TDEAVKLLAN SVLNDVHPRV PNFRYFIWSV
PMNNWFQSLV WLYTLSFDEK GLMATPSLFT TSKVYKQHGN IMKVASPENS SNSMENATKS
ILDKLDLLYL QLPSSVNHDS SLRNK
