位置:首页 > 蛋白库 > FTHS_MALP2
FTHS_MALP2
ID   FTHS_MALP2              Reviewed;         530 AA.
AC   Q8EUQ1;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Formate--tetrahydrofolate ligase {ECO:0000255|HAMAP-Rule:MF_01543};
DE            EC=6.3.4.3 {ECO:0000255|HAMAP-Rule:MF_01543};
DE   AltName: Full=Formyltetrahydrofolate synthetase {ECO:0000255|HAMAP-Rule:MF_01543};
DE            Short=FHS {ECO:0000255|HAMAP-Rule:MF_01543};
DE            Short=FTHFS {ECO:0000255|HAMAP-Rule:MF_01543};
GN   Name=fhs {ECO:0000255|HAMAP-Rule:MF_01543}; OrderedLocusNames=MYPE8690;
OS   Malacoplasma penetrans (strain HF-2) (Mycoplasma penetrans).
OC   Bacteria; Tenericutes; Mycoplasmoidales; Mycoplasmoidaceae; Malacoplasma.
OX   NCBI_TaxID=272633;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HF-2;
RX   PubMed=12466555; DOI=10.1093/nar/gkf667;
RA   Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K.,
RA   Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.;
RT   "The complete genomic sequence of Mycoplasma penetrans, an intracellular
RT   bacterial pathogen in humans.";
RL   Nucleic Acids Res. 30:5293-5300(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-
CC         formyltetrahydrofolate + ADP + phosphate; Xref=Rhea:RHEA:20221,
CC         ChEBI:CHEBI:15740, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57453, ChEBI:CHEBI:57454, ChEBI:CHEBI:456216; EC=6.3.4.3;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01543};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000255|HAMAP-Rule:MF_01543}.
CC   -!- SIMILARITY: Belongs to the formate--tetrahydrofolate ligase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01543}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000026; BAC44661.1; -; Genomic_DNA.
DR   RefSeq; WP_011077690.1; NC_004432.1.
DR   AlphaFoldDB; Q8EUQ1; -.
DR   SMR; Q8EUQ1; -.
DR   STRING; 272633.26454332; -.
DR   EnsemblBacteria; BAC44661; BAC44661; BAC44661.
DR   KEGG; mpe:MYPE8690; -.
DR   eggNOG; COG2759; Bacteria.
DR   HOGENOM; CLU_003601_3_3_14; -.
DR   OMA; CGEIMTM; -.
DR   OrthoDB; 177859at2; -.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000002522; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01543; FTHFS; 1.
DR   InterPro; IPR000559; Formate_THF_ligase.
DR   InterPro; IPR020628; Formate_THF_ligase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01268; FTHFS; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00721; FTHFS_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Ligase; Nucleotide-binding; One-carbon metabolism;
KW   Reference proteome.
FT   CHAIN           1..530
FT                   /note="Formate--tetrahydrofolate ligase"
FT                   /id="PRO_0000199362"
FT   BINDING         46..53
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01543"
SQ   SEQUENCE   530 AA;  59817 MW;  2F9A209EA3D87C9A CRC64;
     MTNNIFKYFN IKELEKFGKF YKVKKEYEIP KKLESKLILV TSINPTPEGE GKTTTLIGIN
     DCLNYFGKES IACLRQPSMG PYFGIKGGAT GSGKCEIQNP EKVNCGFTND FYAIEAANNL
     IMSVIENEIY FNTDLEIDPQ KIIWKRCIDI NDRSLRDINY QVSKNTKINS SFSITAASNL
     MALFCLAKSK SDFKKRIENT LVAFSKSNKA IYVKDLNIID SIMLILDDAL KPNLVFSQDN
     NPIIMHGGPF ANIAHGCNSV IALSCGLNKA EYVLTEAGFG SELGAEKFIN ILCRETNLVP
     NLVVLTITLK AIKYHGVNNS NNTSPLTDEK EKIDIGFNNV IHHFNLLKNL NLNVCIVINK
     FSDDNKNELD YLFNKSSELT KTVISTMWQD GASKNKSLFE TIIESVQEPK PINWTYDLKD
     NAVNKINDLS TKVYNGATIT YSDLATAKLK DNENWIQDYY VCGAKTPYSP SIKNEYMDTN
     KHDIHVEDIE INHAVKFIIP IFSKTFLMPG LPKVPNAKKI KINFDKFKYE
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024