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FTHS_THEAC
ID   FTHS_THEAC              Reviewed;         536 AA.
AC   Q9HI67;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Formate--tetrahydrofolate ligase {ECO:0000255|HAMAP-Rule:MF_01543};
DE            EC=6.3.4.3 {ECO:0000255|HAMAP-Rule:MF_01543};
DE   AltName: Full=Formyltetrahydrofolate synthetase {ECO:0000255|HAMAP-Rule:MF_01543};
DE            Short=FHS {ECO:0000255|HAMAP-Rule:MF_01543};
DE            Short=FTHFS {ECO:0000255|HAMAP-Rule:MF_01543};
GN   Name=fhs {ECO:0000255|HAMAP-Rule:MF_01543}; OrderedLocusNames=Ta1478;
OS   Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS   15155 / AMRC-C165).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273075;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RX   PubMed=11029001; DOI=10.1038/35035069;
RA   Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C.,
RA   Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT   "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT   acidophilum.";
RL   Nature 407:508-513(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-
CC         formyltetrahydrofolate + ADP + phosphate; Xref=Rhea:RHEA:20221,
CC         ChEBI:CHEBI:15740, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57453, ChEBI:CHEBI:57454, ChEBI:CHEBI:456216; EC=6.3.4.3;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01543};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000255|HAMAP-Rule:MF_01543}.
CC   -!- SIMILARITY: Belongs to the formate--tetrahydrofolate ligase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01543}.
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DR   EMBL; AL445067; CAC12596.1; -; Genomic_DNA.
DR   RefSeq; WP_010901878.1; NC_002578.1.
DR   AlphaFoldDB; Q9HI67; -.
DR   SMR; Q9HI67; -.
DR   STRING; 273075.Ta1478; -.
DR   EnsemblBacteria; CAC12596; CAC12596; CAC12596.
DR   GeneID; 1456930; -.
DR   KEGG; tac:Ta1478; -.
DR   eggNOG; arCOG04541; Archaea.
DR   HOGENOM; CLU_003601_3_3_2; -.
DR   OMA; CGEIMTM; -.
DR   OrthoDB; 15172at2157; -.
DR   BRENDA; 6.3.4.3; 6324.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000001024; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01543; FTHFS; 1.
DR   InterPro; IPR000559; Formate_THF_ligase.
DR   InterPro; IPR020628; Formate_THF_ligase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01268; FTHFS; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00721; FTHFS_1; 1.
DR   PROSITE; PS00722; FTHFS_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Ligase; Nucleotide-binding; One-carbon metabolism;
KW   Reference proteome.
FT   CHAIN           1..536
FT                   /note="Formate--tetrahydrofolate ligase"
FT                   /id="PRO_0000199415"
FT   BINDING         51..58
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01543"
SQ   SEQUENCE   536 AA;  57647 MW;  82D0405ABA148E7C CRC64;
     MRDIEEIIKE IGLGRDDYEL YGRYMAKLDL GLQNRGRPRA KLILVTAMTP TPAGEGKTTT
     TIGLGQAMKK LGKNVAIAIR EPSLGPCFGI KGGATGGGKS KVEPSDRINL FFTGDFPTIT
     AAHNLLSAMI NNHMYHGNEL NLDPKRITFP RTIDMNDRSL RSILVGVGPR DMGVLAGDSF
     VITPASEVMA ITGLSLNYQD LKARLSRILA GFTTKNKPVF AGDLKAEGSM AALLRDALKP
     NLVQTTEGVP AFVHTGPFGN IAHGTSSLVA DKIALNLFDY VITEAGFGSD LGAEKFFNLA
     SRIGDLPINA VVLVATIRAI KHHGGSKKEG EDIDAVKTGS KNLIRHVQNI RNFGIDPVVA
     VNRFPTDTDG EIRALGEILD SNGIKWALSE VFAKGGEGGI DLANKVLASL GSHEIKRTYD
     LKDDIRTKIE KIARNVYGAD GVIFEKKALS DMKKAEEIME NPYVCMAKTQ YSFSDDASLL
     NDPHGFTIKV QSINISSGAG FVVPILGEIM TMPGLPKHPA AENIDLTDSG EITGLF
 
 
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