FTR1_YEAST
ID FTR1_YEAST Reviewed; 404 AA.
AC P40088; D3DM52;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Plasma membrane iron permease;
GN Name=FTR1; OrderedLocusNames=YER145C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169868;
RA Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA Botstein D., Davis R.W.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL Nature 387:78-81(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP CHARACTERIZATION.
RX PubMed=8599111; DOI=10.1126/science.271.5255.1552;
RA Stearman R., Yuan D.S., Yamaguchi-Iwai Y., Klausner R.D., Dancis A.;
RT "A permease-oxidase complex involved in high-affinity iron uptake in
RT yeast.";
RL Science 271:1552-1557(1996).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Permease for high affinity iron uptake.
CC -!- INTERACTION:
CC P40088; P38993: FET3; NbExp=6; IntAct=EBI-7138, EBI-6876;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Present with 8370 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC
CC 9.A.10.1) family. {ECO:0000305}.
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DR EMBL; U18917; AAB64672.1; -; Genomic_DNA.
DR EMBL; BK006939; DAA07806.1; -; Genomic_DNA.
DR PIR; S50648; S50648.
DR RefSeq; NP_011072.1; NM_001179035.1.
DR AlphaFoldDB; P40088; -.
DR BioGRID; 36894; 104.
DR ComplexPortal; CPX-868; FET3-FTR1 high affinity iron permease complex.
DR DIP; DIP-5376N; -.
DR IntAct; P40088; 28.
DR MINT; P40088; -.
DR STRING; 4932.YER145C; -.
DR TCDB; 2.A.108.1.1; the iron/lead transporter (ilt) family.
DR iPTMnet; P40088; -.
DR MaxQB; P40088; -.
DR PaxDb; P40088; -.
DR PRIDE; P40088; -.
DR EnsemblFungi; YER145C_mRNA; YER145C; YER145C.
DR GeneID; 856888; -.
DR KEGG; sce:YER145C; -.
DR SGD; S000000947; FTR1.
DR VEuPathDB; FungiDB:YER145C; -.
DR eggNOG; ENOG502QQWE; Eukaryota.
DR GeneTree; ENSGT00940000176478; -.
DR HOGENOM; CLU_046738_1_1_1; -.
DR InParanoid; P40088; -.
DR OMA; ITMLKMD; -.
DR BioCyc; YEAST:G3O-30306-MON; -.
DR PRO; PR:P40088; -.
DR Proteomes; UP000002311; Chromosome V.
DR RNAct; P40088; protein.
DR GO; GO:0033573; C:high-affinity iron permease complex; IDA:SGD.
DR GO; GO:0005886; C:plasma membrane; IDA:SGD.
DR GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IDA:SGD.
DR GO; GO:1901684; P:arsenate ion transmembrane transport; IGI:SGD.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0098706; P:iron ion import across cell outer membrane; IDA:ComplexPortal.
DR GO; GO:0034755; P:iron ion transmembrane transport; IMP:SGD.
DR InterPro; IPR005217; FTR1-like.
DR InterPro; IPR004923; FTR1/Fip1/EfeU.
DR PANTHER; PTHR31632; PTHR31632; 1.
DR Pfam; PF03239; FTR1; 1.
DR TIGRFAMs; TIGR00145; TIGR00145; 1.
PE 1: Evidence at protein level;
KW Ion transport; Iron; Iron transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..404
FT /note="Plasma membrane iron permease"
FT /id="PRO_0000159649"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 404 AA; 45722 MW; 3E155BF6195AD867 CRC64;
MPNKVFNVAV FFVVFRECLE AVIVISVLLS FLKQAIGEHD RALYRKLRIQ VWVGVLLGFI
ICLAIGAGFI GAYYSLQKDI FGSAEDLWEG IFCMIATIMI SMMGIPMLRM NKMQSKWRVK
IARSLVEIPH RKRDYFKIGF LSRRYAMFLL PFITVLREGL EAVVFVAGAG ITTQGSHASA
YPLPVVVGLI CGGLVGYLLY YGASKSSLQI FLILSTSILY LISAGLFSRG AWYFENYRFN
LASGGDASEG GDGNGSYNIR KAVYHVNCCN PELDNGWDIF NALLGWQNTG YLSSMLCYNI
YWLVLIIVLS LMIFEERRGH LPFTKNLQLK HLNPGYWIKN KKKQELTEEQ KRQLFAKMEN
INFNEDGEIN VQENYELPEQ TTSHSSSQNV ATDKEVLHVK ADSL
