FTRV_SYNY3
ID FTRV_SYNY3 Reviewed; 75 AA.
AC Q55781;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Ferredoxin-thioredoxin reductase, variable chain;
DE Short=FTR-V;
DE AltName: Full=Ferredoxin-thioredoxin reductase subunit A;
DE Short=FTR-A;
GN Name=ftrV; OrderedLocusNames=ssr0330;
OS Synechocystis sp. (strain PCC 6803 / Kazusa).
OC Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC unclassified Synechocystis.
OX NCBI_TaxID=1111708;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27184 / PCC 6803 / N-1;
RX PubMed=8590279; DOI=10.1093/dnares/2.4.153;
RA Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N.,
RA Sugiura M., Tabata S.;
RT "Sequence analysis of the genome of the unicellular cyanobacterium
RT Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region
RT from map positions 64% to 92% of the genome.";
RL DNA Res. 2:153-166(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 6803 / Kazusa;
RX PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence analysis of the genome of the unicellular cyanobacterium
RT Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT genome and assignment of potential protein-coding regions.";
RL DNA Res. 3:109-136(1996).
RN [3]
RP PROTEIN SEQUENCE OF 1-7.
RX PubMed=9298645; DOI=10.1002/elps.1150180806;
RA Sazuka T., Ohara O.;
RT "Towards a proteome project of cyanobacterium Synechocystis sp. strain
RT PCC6803: linking 130 protein spots with their respective genes.";
RL Electrophoresis 18:1252-1258(1997).
RN [4]
RP X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH FTRC, AND SUBUNIT.
RC STRAIN=ATCC 27184 / PCC 6803 / N-1;
RX PubMed=10649999; DOI=10.1126/science.287.5453.655;
RA Dai S., Schwendtmayer C., Schurmann P., Ramaswamy S., Eklund H.;
RT "Redox signaling in chloroplasts: cleavage of disulfides by an iron-sulfur
RT cluster.";
RL Science 287:655-658(2000).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 1-74 IN COMPLEXES WITH FTRC;
RP PETF/FERREDOXIN; TRX-F AND TRX-M, FUNCTION, AND SUBUNIT.
RC STRAIN=ATCC 27184 / PCC 6803 / N-1;
RX PubMed=17611542; DOI=10.1038/nature05937;
RA Dai S., Friemann R., Glauser D.A., Bourquin F., Manieri W., Schurmann P.,
RA Eklund H.;
RT "Structural snapshots along the reaction pathway of ferredoxin-thioredoxin
RT reductase.";
RL Nature 448:92-96(2007).
CC -!- FUNCTION: Variable subunit of the ferredoxin-thioredoxin reductase
CC (FTR), which catalyzes the two-electron reduction of thioredoxins by
CC the electrons provided by reduced ferredoxin.
CC {ECO:0000269|PubMed:17611542}.
CC -!- SUBUNIT: Heterodimer of subunit A (variable subunit) and subunit B
CC (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin
CC and thioredoxin. {ECO:0000269|PubMed:10649999,
CC ECO:0000269|PubMed:17611542}.
CC -!- INTERACTION:
CC Q55781; Q55389: ftrC; NbExp=4; IntAct=EBI-863219, EBI-863211;
CC Q55781; P27320: petF; NbExp=4; IntAct=EBI-863219, EBI-863421;
CC -!- SIMILARITY: Belongs to the ferredoxin thioredoxin reductase alpha
CC subunit family. {ECO:0000305}.
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DR EMBL; BA000022; BAA10432.1; -; Genomic_DNA.
DR PIR; S76586; S76586.
DR PDB; 1DJ7; X-ray; 1.60 A; B=1-75.
DR PDB; 2PU9; X-ray; 1.65 A; B=1-74.
DR PDB; 2PUK; X-ray; 3.00 A; B/F=1-73.
DR PDB; 2PUO; X-ray; 1.70 A; B=1-73.
DR PDB; 2PVD; X-ray; 1.95 A; B=1-73.
DR PDB; 2PVG; X-ray; 2.40 A; B=1-73.
DR PDB; 2PVO; X-ray; 3.40 A; B=1-74.
DR PDBsum; 1DJ7; -.
DR PDBsum; 2PU9; -.
DR PDBsum; 2PUK; -.
DR PDBsum; 2PUO; -.
DR PDBsum; 2PVD; -.
DR PDBsum; 2PVG; -.
DR PDBsum; 2PVO; -.
DR AlphaFoldDB; Q55781; -.
DR SMR; Q55781; -.
DR DIP; DIP-35306N; -.
DR IntAct; Q55781; 2.
DR MINT; Q55781; -.
DR STRING; 1148.1001695; -.
DR PaxDb; Q55781; -.
DR EnsemblBacteria; BAA10432; BAA10432; BAA10432.
DR KEGG; syn:ssr0330; -.
DR eggNOG; ENOG5032ZFB; Bacteria.
DR InParanoid; Q55781; -.
DR OMA; YHHPEHR; -.
DR PhylomeDB; Q55781; -.
DR BioCyc; MetaCyc:MON-14462; -.
DR EvolutionaryTrace; Q55781; -.
DR Proteomes; UP000001425; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0015979; P:photosynthesis; IEA:InterPro.
DR InterPro; IPR008990; Elect_transpt_acc-like_dom_sf.
DR InterPro; IPR004207; Fd_thioredoxin_Rdtase_alpha.
DR InterPro; IPR044166; FTRV.
DR PANTHER; PTHR46937; PTHR46937; 1.
DR Pfam; PF02941; FeThRed_A; 1.
DR SUPFAM; SSF50090; SSF50090; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Oxidoreductase;
KW Reference proteome.
FT CHAIN 1..75
FT /note="Ferredoxin-thioredoxin reductase, variable chain"
FT /id="PRO_0000087366"
FT REGION 43..46
FT /note="Interaction with ferredoxin"
FT /evidence="ECO:0000250"
FT STRAND 6..9
FT /evidence="ECO:0007829|PDB:1DJ7"
FT STRAND 14..16
FT /evidence="ECO:0007829|PDB:1DJ7"
FT HELIX 19..21
FT /evidence="ECO:0007829|PDB:2PUO"
FT STRAND 32..38
FT /evidence="ECO:0007829|PDB:1DJ7"
FT STRAND 40..42
FT /evidence="ECO:0007829|PDB:1DJ7"
FT STRAND 53..57
FT /evidence="ECO:0007829|PDB:1DJ7"
FT TURN 58..60
FT /evidence="ECO:0007829|PDB:1DJ7"
FT STRAND 61..65
FT /evidence="ECO:0007829|PDB:1DJ7"
FT HELIX 67..69
FT /evidence="ECO:0007829|PDB:1DJ7"
FT STRAND 70..72
FT /evidence="ECO:0007829|PDB:1DJ7"
SQ SEQUENCE 75 AA; 8558 MW; 37C5E0D41C22C18E CRC64;
MNVGDRVRVT SSVVVYHHPE HKKTAFDLQG MEGEVAAVLT EWQGRPISAN LPVLVKFEQR
FKAHFRPDEV TLIED
