ID   FTR_METAC               Reviewed;         297 AA.
AC   Q8TUQ5;
DT   10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Formylmethanofuran--tetrahydromethanopterin formyltransferase {ECO:0000255|HAMAP-Rule:MF_00579};
DE            Short=Ftr {ECO:0000255|HAMAP-Rule:MF_00579};
DE            EC=2.3.1.101 {ECO:0000255|HAMAP-Rule:MF_00579};
DE   AltName: Full=H4MPT formyltransferase {ECO:0000255|HAMAP-Rule:MF_00579};
GN   Name=ftr {ECO:0000255|HAMAP-Rule:MF_00579}; OrderedLocusNames=MA_0010;
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R.,
RA   Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J.,
RA   Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A.,
RA   White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H.,
RA   Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V.,
RA   Zinder S.H., Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
CC   -!- FUNCTION: Catalyzes the reversible transfer of a formyl group from
CC       formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to
CC       produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and
CC       methanofuran (MFR). {ECO:0000255|HAMAP-Rule:MF_00579}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran
CC         = methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin;
CC         Xref=Rhea:RHEA:18061, ChEBI:CHEBI:15378, ChEBI:CHEBI:57727,
CC         ChEBI:CHEBI:58018, ChEBI:CHEBI:58103, ChEBI:CHEBI:58151;
CC         EC=2.3.1.101; Evidence={ECO:0000255|HAMAP-Rule:MF_00579};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC       methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 2/3.
CC       {ECO:0000255|HAMAP-Rule:MF_00579}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_00579}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00579}.
CC   -!- SIMILARITY: Belongs to the FTR family. {ECO:0000255|HAMAP-
CC       Rule:MF_00579}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE010299; AAM03464.1; -; Genomic_DNA.
DR   RefSeq; WP_011020069.1; NC_003552.1.
DR   AlphaFoldDB; Q8TUQ5; -.
DR   SMR; Q8TUQ5; -.
DR   STRING; 188937.MA_0010; -.
DR   PRIDE; Q8TUQ5; -.
DR   EnsemblBacteria; AAM03464; AAM03464; MA_0010.
DR   GeneID; 1471902; -.
DR   KEGG; mac:MA_0010; -.
DR   HOGENOM; CLU_081314_0_0_2; -.
DR   InParanoid; Q8TUQ5; -.
DR   OMA; VIMCPAE; -.
DR   OrthoDB; 62652at2157; -.
DR   PhylomeDB; Q8TUQ5; -.
DR   UniPathway; UPA00640; UER00693.
DR   Proteomes; UP000002487; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030270; F:formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.520; -; 2.
DR   HAMAP; MF_00579; FTR; 1.
DR   InterPro; IPR014053; ForMFR_H4MPT_ForTrfase.
DR   InterPro; IPR002770; ForMFR_H4MPT_ForTrfase_C.
DR   InterPro; IPR023447; ForMFR_H4MPT_ForTrfase_fd-like.
DR   InterPro; IPR022667; ForMFR_H4MPT_ForTrfase_N.
DR   Pfam; PF01913; FTR; 1.
DR   Pfam; PF02741; FTR_C; 1.
DR   PIRSF; PIRSF006414; Ftr_formyl_trnsf; 1.
DR   SUPFAM; SSF55112; SSF55112; 2.
DR   TIGRFAMs; TIGR03119; one_C_fhcD; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Cytoplasm; Methanogenesis; One-carbon metabolism;
KW   Reference proteome; Transferase.
FT   CHAIN           1..297
FT                   /note="Formylmethanofuran--tetrahydromethanopterin
FT                   formyltransferase"
FT                   /id="PRO_0000138116"
SQ   SEQUENCE   297 AA;  31575 MW;  C340E31F470E5445 CRC64;
     MEINGVEIED TYAEAFPIKI ARVLITAATK RWAQVAATEA TGFATSVIMC PAEAGIEKFA
     SPSETPDGRP GVYVQICTFK YEALEEQLLE RIGQCVLTAP TTAVFNGLPD AEKQFNIGFK
     LKFFGDGMES EAQVAGRKVY KVPIMEGDFV TEENIGAIAG IAGGNFFIFG DSQMSALTAA
     EAAVDAIEEL EGTIAPFPGG IVASGSKSGA NKYKFLKATA NEKFCPSIKD KVENTEVPAD
     VNAIYEIVIN GLDEASIKAA MKAGIEAAVT VPGIKKISAG NYGGKLGKYQ FKLHELF