ID   FTR_METFK               Reviewed;         302 AA.
AC   Q1H0Q5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Formylmethanofuran--tetrahydromethanopterin formyltransferase {ECO:0000255|HAMAP-Rule:MF_00579};
DE            Short=Ftr {ECO:0000255|HAMAP-Rule:MF_00579};
DE            EC=2.3.1.101 {ECO:0000255|HAMAP-Rule:MF_00579};
DE   AltName: Full=H4MPT formyltransferase {ECO:0000255|HAMAP-Rule:MF_00579};
GN   Name=ffsA {ECO:0000255|HAMAP-Rule:MF_00579}; OrderedLocusNames=Mfla_1664;
OS   Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC   Methylophilaceae; Methylobacillus.
OX   NCBI_TaxID=265072;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KT / ATCC 51484 / DSM 6875;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Anderson I., Richardson P.;
RT   "Complete sequence of Methylobacillus flagellatus KT.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the transfer of a formyl group from 5-formyl
CC       tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) to
CC       produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin
CC       (H(4)MPT). {ECO:0000255|HAMAP-Rule:MF_00579}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran
CC         = methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin;
CC         Xref=Rhea:RHEA:18061, ChEBI:CHEBI:15378, ChEBI:CHEBI:57727,
CC         ChEBI:CHEBI:58018, ChEBI:CHEBI:58103, ChEBI:CHEBI:58151;
CC         EC=2.3.1.101; Evidence={ECO:0000255|HAMAP-Rule:MF_00579};
CC   -!- PATHWAY: One-carbon metabolism; formaldehyde degradation; formate from
CC       formaldehyde (H(4)MPT route): step 4/5. {ECO:0000255|HAMAP-
CC       Rule:MF_00579}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_00579}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00579}.
CC   -!- SIMILARITY: Belongs to the FTR family. {ECO:0000255|HAMAP-
CC       Rule:MF_00579}.
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DR   EMBL; CP000284; ABE49932.1; -; Genomic_DNA.
DR   RefSeq; WP_011479886.1; NC_007947.1.
DR   AlphaFoldDB; Q1H0Q5; -.
DR   SMR; Q1H0Q5; -.
DR   STRING; 265072.Mfla_1664; -.
DR   EnsemblBacteria; ABE49932; ABE49932; Mfla_1664.
DR   KEGG; mfa:Mfla_1664; -.
DR   eggNOG; COG2037; Bacteria.
DR   HOGENOM; CLU_081314_0_0_4; -.
DR   OMA; VIMCPAE; -.
DR   OrthoDB; 895502at2; -.
DR   UniPathway; UPA00562; UER00704.
DR   Proteomes; UP000002440; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030270; F:formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046294; P:formaldehyde catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.520; -; 2.
DR   HAMAP; MF_00579; FTR; 1.
DR   InterPro; IPR014053; ForMFR_H4MPT_ForTrfase.
DR   InterPro; IPR002770; ForMFR_H4MPT_ForTrfase_C.
DR   InterPro; IPR023447; ForMFR_H4MPT_ForTrfase_fd-like.
DR   InterPro; IPR022667; ForMFR_H4MPT_ForTrfase_N.
DR   Pfam; PF01913; FTR; 1.
DR   Pfam; PF02741; FTR_C; 1.
DR   PIRSF; PIRSF006414; Ftr_formyl_trnsf; 1.
DR   SUPFAM; SSF55112; SSF55112; 2.
DR   TIGRFAMs; TIGR03119; one_C_fhcD; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Cytoplasm; One-carbon metabolism; Reference proteome;
KW   Transferase.
FT   CHAIN           1..302
FT                   /note="Formylmethanofuran--tetrahydromethanopterin
FT                   formyltransferase"
FT                   /id="PRO_1000025195"
SQ   SEQUENCE   302 AA;  32319 MW;  232BCF0B1F93AACD CRC64;
     MIINGVTIDD TFAEAFGMRG TRVIITAQNL RWAYNAARAM TGFATSVIAC GVEAGIEREL
     TPEETPDGRP GVSILMFAMS SAVLIKQLET RMGQCVLTCP TAAAFSGIDE GYPEITRINL
     GKNLRFFGDG FQISKVFNGK RYWRVPVMDG EFLTEETTGM IRSVGGGNFL ILAESQPQAL
     AACEAAIDAM SKIPNVIMPF PGGVVRSGSK VGSKYKALIA STNDAFCPTL KGITKTELSP
     EIESVMEIVI DGLTDPDIRV AMRAGIAAAC ELGAKNGIKR ISAGNYGGKL GPYHFKLREI
     MA