ID   FTR_METFV               Reviewed;         297 AA.
AC   Q49168; E3GYF3;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Formylmethanofuran--tetrahydromethanopterin formyltransferase {ECO:0000255|HAMAP-Rule:MF_00579};
DE            Short=Ftr {ECO:0000255|HAMAP-Rule:MF_00579};
DE            EC=2.3.1.101 {ECO:0000255|HAMAP-Rule:MF_00579};
DE   AltName: Full=H4MPT formyltransferase {ECO:0000255|HAMAP-Rule:MF_00579};
GN   Name=ftr {ECO:0000255|HAMAP-Rule:MF_00579}; OrderedLocusNames=Mfer_0535;
OS   Methanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanothermaceae; Methanothermus.
OX   NCBI_TaxID=523846;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-37.
RC   STRAIN=ATCC 43054 / DSM 2088 / JCM 10308 / V24 S;
RX   PubMed=7506350; DOI=10.1007/bf00277350;
RA   Lehmacher A.;
RT   "Cloning, sequencing and transcript analysis of the gene encoding
RT   formylmethanofuran: tetrahydromethanopterin formyltransferase from the
RT   hyperthermophilic Methanothermus fervidus.";
RL   Mol. Gen. Genet. 242:73-80(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43054 / DSM 2088 / JCM 10308 / V24 S;
RX   PubMed=21304736; DOI=10.4056/sigs.1283367;
RA   Anderson I., Djao O.D., Misra M., Chertkov O., Nolan M., Lucas S.,
RA   Lapidus A., Del Rio T.G., Tice H., Cheng J.F., Tapia R., Han C.,
RA   Goodwin L., Pitluck S., Liolios K., Ivanova N., Mavromatis K.,
RA   Mikhailova N., Pati A., Brambilla E., Chen A., Palaniappan K., Land M.,
RA   Hauser L., Chang Y.J., Jeffries C.D., Sikorski J., Spring S., Rohde M.,
RA   Eichinger K., Huber H., Wirth R., Goker M., Detter J.C., Woyke T.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P.,
RA   Kyrpides N.C.;
RT   "Complete genome sequence of Methanothermus fervidus type strain (V24S).";
RL   Stand. Genomic Sci. 3:315-324(2010).
CC   -!- FUNCTION: Catalyzes the reversible transfer of a formyl group from
CC       formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to
CC       produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and
CC       methanofuran (MFR). {ECO:0000255|HAMAP-Rule:MF_00579}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran
CC         = methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin;
CC         Xref=Rhea:RHEA:18061, ChEBI:CHEBI:15378, ChEBI:CHEBI:57727,
CC         ChEBI:CHEBI:58018, ChEBI:CHEBI:58103, ChEBI:CHEBI:58151;
CC         EC=2.3.1.101; Evidence={ECO:0000255|HAMAP-Rule:MF_00579};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC       methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 2/3.
CC       {ECO:0000255|HAMAP-Rule:MF_00579}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_00579}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00579}.
CC   -!- SIMILARITY: Belongs to the FTR family. {ECO:0000255|HAMAP-
CC       Rule:MF_00579}.
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DR   EMBL; X70784; CAA50057.1; -; Genomic_DNA.
DR   EMBL; CP002278; ADP77335.1; -; Genomic_DNA.
DR   PIR; S41564; S41564.
DR   RefSeq; WP_013413613.1; NC_014658.1.
DR   AlphaFoldDB; Q49168; -.
DR   SMR; Q49168; -.
DR   STRING; 523846.Mfer_0535; -.
DR   EnsemblBacteria; ADP77335; ADP77335; Mfer_0535.
DR   GeneID; 9962259; -.
DR   KEGG; mfv:Mfer_0535; -.
DR   HOGENOM; CLU_081314_0_0_2; -.
DR   OMA; VIMCPAE; -.
DR   OrthoDB; 62652at2157; -.
DR   BRENDA; 2.3.1.101; 3286.
DR   UniPathway; UPA00640; UER00693.
DR   Proteomes; UP000002315; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030270; F:formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.520; -; 2.
DR   HAMAP; MF_00579; FTR; 1.
DR   InterPro; IPR014053; ForMFR_H4MPT_ForTrfase.
DR   InterPro; IPR002770; ForMFR_H4MPT_ForTrfase_C.
DR   InterPro; IPR023447; ForMFR_H4MPT_ForTrfase_fd-like.
DR   InterPro; IPR022667; ForMFR_H4MPT_ForTrfase_N.
DR   Pfam; PF01913; FTR; 1.
DR   Pfam; PF02741; FTR_C; 1.
DR   PIRSF; PIRSF006414; Ftr_formyl_trnsf; 1.
DR   SUPFAM; SSF55112; SSF55112; 2.
DR   TIGRFAMs; TIGR03119; one_C_fhcD; 1.
PE   1: Evidence at protein level;
KW   Acyltransferase; Cytoplasm; Direct protein sequencing; Methanogenesis;
KW   One-carbon metabolism; Reference proteome; Transferase.
FT   CHAIN           1..297
FT                   /note="Formylmethanofuran--tetrahydromethanopterin
FT                   formyltransferase"
FT                   /id="PRO_0000138118"
SQ   SEQUENCE   297 AA;  31832 MW;  6129F4C5C3290B7E CRC64;
     MKVNGVEIED TFAEAFDIKV SRILVTAASK RLAKIAAREA TGYGTSVIGC PAEAGIDTYI
     PPKNTPDQRP GFTIIICNPS KKKLDHELLE RVGMTILTAP TAAAFDALEN AEEKVNTGFK
     LKFFGDGYEK EGEVQGRKVH IIPIMSGEFI VEEKFGIKSG VAGGNFFIMA ETQGSALLAA
     EMAVDAIKSV EGVMTPFPGG IVASGSKVGS KKYDFLDAST NEKMCVTLKD EIEDSEVPED
     VNGIYEIVID GIDEESVKKA MKVGIEAACK VPGVKKISAG NYGGKLGKYK LHLHDLF