ID   FTR_METJA               Reviewed;         301 AA.
AC   Q57766;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 124.
DE   RecName: Full=Formylmethanofuran--tetrahydromethanopterin formyltransferase {ECO:0000255|HAMAP-Rule:MF_00579};
DE            Short=Ftr {ECO:0000255|HAMAP-Rule:MF_00579};
DE            EC=2.3.1.101 {ECO:0000255|HAMAP-Rule:MF_00579};
DE   AltName: Full=H4MPT formyltransferase {ECO:0000255|HAMAP-Rule:MF_00579};
GN   Name=ftr {ECO:0000255|HAMAP-Rule:MF_00579}; OrderedLocusNames=MJ0318;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: Catalyzes the reversible transfer of a formyl group from
CC       formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to
CC       produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and
CC       methanofuran (MFR). {ECO:0000255|HAMAP-Rule:MF_00579}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran
CC         = methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin;
CC         Xref=Rhea:RHEA:18061, ChEBI:CHEBI:15378, ChEBI:CHEBI:57727,
CC         ChEBI:CHEBI:58018, ChEBI:CHEBI:58103, ChEBI:CHEBI:58151;
CC         EC=2.3.1.101; Evidence={ECO:0000255|HAMAP-Rule:MF_00579};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC       methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 2/3.
CC       {ECO:0000255|HAMAP-Rule:MF_00579}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_00579}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00579}.
CC   -!- SIMILARITY: Belongs to the FTR family. {ECO:0000255|HAMAP-
CC       Rule:MF_00579}.
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DR   EMBL; L77117; AAB98303.1; -; Genomic_DNA.
DR   PIR; G64339; G64339.
DR   RefSeq; WP_010869816.1; NC_000909.1.
DR   AlphaFoldDB; Q57766; -.
DR   SMR; Q57766; -.
DR   STRING; 243232.MJ_0318; -.
DR   EnsemblBacteria; AAB98303; AAB98303; MJ_0318.
DR   GeneID; 1451173; -.
DR   KEGG; mja:MJ_0318; -.
DR   eggNOG; arCOG02695; Archaea.
DR   HOGENOM; CLU_081314_0_0_2; -.
DR   InParanoid; Q57766; -.
DR   OMA; VIMCPAE; -.
DR   OrthoDB; 62652at2157; -.
DR   PhylomeDB; Q57766; -.
DR   UniPathway; UPA00640; UER00693.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030270; F:formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.520; -; 2.
DR   HAMAP; MF_00579; FTR; 1.
DR   InterPro; IPR014053; ForMFR_H4MPT_ForTrfase.
DR   InterPro; IPR002770; ForMFR_H4MPT_ForTrfase_C.
DR   InterPro; IPR023447; ForMFR_H4MPT_ForTrfase_fd-like.
DR   InterPro; IPR022667; ForMFR_H4MPT_ForTrfase_N.
DR   Pfam; PF01913; FTR; 1.
DR   Pfam; PF02741; FTR_C; 1.
DR   PIRSF; PIRSF006414; Ftr_formyl_trnsf; 1.
DR   SUPFAM; SSF55112; SSF55112; 2.
DR   TIGRFAMs; TIGR03119; one_C_fhcD; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Cytoplasm; Methanogenesis; One-carbon metabolism;
KW   Reference proteome; Transferase.
FT   CHAIN           1..301
FT                   /note="Formylmethanofuran--tetrahydromethanopterin
FT                   formyltransferase"
FT                   /id="PRO_0000138119"
SQ   SEQUENCE   301 AA;  32445 MW;  28207E48812B0296 CRC64;
     MEINGVYIED TFAEAFPIWV SRVLITAATK KWAKIAATEA TGFGCSVIMC PAEAGIEKYV
     PPSKTPDGRP GFIIQICHPK KSELEHQMLE RLGQCVLTCP TTAIFDAMGD MADEQLKVGF
     KLKFFGDGYE KKDELYGRKV YKIPIMGGEF ITEAKFGIKK GVAGGNFFIM ADTNASALIA
     AEAAVNAIAS VDGVITPFPG GVVASGSKVG ASNPKYKFMV ATTNHKMCPT LKGVVEDSEI
     PEDVNGVYEI VIDGVDEESV KEAMKQGILA ATRVKGVKKI TAGNYGGKLG KYQFNLRELF
     E