ID   FTR_METMA               Reviewed;         297 AA.
AC   Q8PXA1;
DT   10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   10-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 131.
DE   RecName: Full=Formylmethanofuran--tetrahydromethanopterin formyltransferase {ECO:0000255|HAMAP-Rule:MF_00579};
DE            Short=Ftr {ECO:0000255|HAMAP-Rule:MF_00579};
DE            EC=2.3.1.101 {ECO:0000255|HAMAP-Rule:MF_00579};
DE   AltName: Full=H4MPT formyltransferase {ECO:0000255|HAMAP-Rule:MF_00579};
GN   Name=ftr {ECO:0000255|HAMAP-Rule:MF_00579}; OrderedLocusNames=MM_1321;
OS   Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM
OS   11833 / OCM 88) (Methanosarcina frisia).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=192952;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88;
RX   PubMed=12125824;
RA   Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A.,
RA   Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C.,
RA   Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S.,
RA   Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P.,
RA   Fritz H.-J., Gottschalk G.;
RT   "The genome of Methanosarcina mazei: evidence for lateral gene transfer
RT   between Bacteria and Archaea.";
RL   J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
CC   -!- FUNCTION: Catalyzes the reversible transfer of a formyl group from
CC       formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to
CC       produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and
CC       methanofuran (MFR). {ECO:0000255|HAMAP-Rule:MF_00579}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran
CC         = methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin;
CC         Xref=Rhea:RHEA:18061, ChEBI:CHEBI:15378, ChEBI:CHEBI:57727,
CC         ChEBI:CHEBI:58018, ChEBI:CHEBI:58103, ChEBI:CHEBI:58151;
CC         EC=2.3.1.101; Evidence={ECO:0000255|HAMAP-Rule:MF_00579};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC       methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 2/3.
CC       {ECO:0000255|HAMAP-Rule:MF_00579}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_00579}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00579}.
CC   -!- SIMILARITY: Belongs to the FTR family. {ECO:0000255|HAMAP-
CC       Rule:MF_00579}.
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DR   EMBL; AE008384; AAM31017.1; -; Genomic_DNA.
DR   RefSeq; WP_011033267.1; NC_003901.1.
DR   AlphaFoldDB; Q8PXA1; -.
DR   SMR; Q8PXA1; -.
DR   STRING; 192952.MM_1321; -.
DR   EnsemblBacteria; AAM31017; AAM31017; MM_1321.
DR   GeneID; 44089064; -.
DR   GeneID; 66137247; -.
DR   KEGG; mma:MM_1321; -.
DR   PATRIC; fig|192952.21.peg.1534; -.
DR   eggNOG; arCOG02695; Archaea.
DR   HOGENOM; CLU_081314_0_0_2; -.
DR   OMA; VIMCPAE; -.
DR   UniPathway; UPA00640; UER00693.
DR   Proteomes; UP000000595; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030270; F:formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.520; -; 2.
DR   HAMAP; MF_00579; FTR; 1.
DR   InterPro; IPR014053; ForMFR_H4MPT_ForTrfase.
DR   InterPro; IPR002770; ForMFR_H4MPT_ForTrfase_C.
DR   InterPro; IPR023447; ForMFR_H4MPT_ForTrfase_fd-like.
DR   InterPro; IPR022667; ForMFR_H4MPT_ForTrfase_N.
DR   Pfam; PF01913; FTR; 1.
DR   Pfam; PF02741; FTR_C; 1.
DR   PIRSF; PIRSF006414; Ftr_formyl_trnsf; 1.
DR   SUPFAM; SSF55112; SSF55112; 2.
DR   TIGRFAMs; TIGR03119; one_C_fhcD; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Cytoplasm; Methanogenesis; One-carbon metabolism;
KW   Reference proteome; Transferase.
FT   CHAIN           1..297
FT                   /note="Formylmethanofuran--tetrahydromethanopterin
FT                   formyltransferase"
FT                   /id="PRO_0000138121"
SQ   SEQUENCE   297 AA;  31561 MW;  CE949BE4F1AAB16C CRC64;
     MEINGVEIED TYAEAFPIKI ARVLITAVTK RWAQVAATEA TGFGTSVIMC PAEAGIERFA
     SPSETPDGRP GAYIQICTFK YEALEEQLLE RIGQCVLTAP TTAVFNGLPD SEKQFNVGFK
     LKFFGDGMES EAQIAGRKVF KVPIMEGDFV TEDNIGAIAG IAGGNFFIFG DSQMSALTAA
     EAAVDAIAEL EGTITPFPGG IVASGSKSGA NKYKFLKATA NEKFCPSIKD KVENTEIPAD
     VNAVYEIVIN GLDEASIKAA MKAGIEAAVT VPGIKKISAG NYGGKLGKYQ FKLHELF