ID   FTSA_BORBU              Reviewed;         413 AA.
AC   Q44774; Q44914; Q44923; Q57474;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Cell division protein FtsA {ECO:0000255|HAMAP-Rule:MF_02033};
GN   Name=ftsA {ECO:0000255|HAMAP-Rule:MF_02033}; OrderedLocusNames=BB_0300;
OS   Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)
OS   (Borrelia burgdorferi).
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX   NCBI_TaxID=224326;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RA   Dunn J.J., Butler-Loffredo L., Kieleczawa J., Medalle J., Luft B.J.;
RL   Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=212;
RA   Ge Y., Old I.G., Saint Girons I., Charon N.W.;
RL   Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX   PubMed=9403685; DOI=10.1038/37551;
RA   Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA   Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L.,
RA   Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L.,
RA   Peterson J.D., Kerlavage A.R., Quackenbush J., Salzberg S.L., Hanson M.,
RA   van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F.,
RA   Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C.,
RA   Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B.,
RA   Smith H.O., Venter J.C.;
RT   "Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.";
RL   Nature 390:580-586(1997).
CC   -!- FUNCTION: Cell division protein that is involved in the assembly of the
CC       Z ring. May serve as a membrane anchor for the Z ring.
CC       {ECO:0000255|HAMAP-Rule:MF_02033}.
CC   -!- SUBUNIT: Self-interacts. Interacts with FtsZ. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_02033}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_02033}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_02033}.
CC       Note=Localizes to the Z ring in an FtsZ-dependent manner. Targeted to
CC       the membrane through a conserved C-terminal amphipathic helix.
CC       {ECO:0000255|HAMAP-Rule:MF_02033}.
CC   -!- SIMILARITY: Belongs to the FtsA/MreB family. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
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DR   EMBL; U43739; AAA85623.1; -; Genomic_DNA.
DR   EMBL; Z12164; CAA78155.1; -; Genomic_DNA.
DR   EMBL; X96685; CAA65463.1; -; Genomic_DNA.
DR   EMBL; X96433; CAA65296.1; -; Genomic_DNA.
DR   EMBL; L76303; AAB51401.1; -; Genomic_DNA.
DR   EMBL; AE000783; AAC66648.1; -; Genomic_DNA.
DR   PIR; D70137; D70137.
DR   RefSeq; NP_212434.1; NC_001318.1.
DR   RefSeq; WP_002656287.1; NC_001318.1.
DR   AlphaFoldDB; Q44774; -.
DR   SMR; Q44774; -.
DR   STRING; 224326.BB_0300; -.
DR   PRIDE; Q44774; -.
DR   DNASU; 1195137; -.
DR   EnsemblBacteria; AAC66648; AAC66648; BB_0300.
DR   GeneID; 56567731; -.
DR   KEGG; bbu:BB_0300; -.
DR   PATRIC; fig|224326.49.peg.699; -.
DR   HOGENOM; CLU_037850_3_2_12; -.
DR   OMA; DGIIRHT; -.
DR   Proteomes; UP000001807; Chromosome.
DR   GO; GO:0032153; C:cell division site; IEA:UniProtKB-UniRule.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_02033; FtsA; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR020823; Cell_div_FtsA.
DR   InterPro; IPR003494; SHS2_FtsA.
DR   Pfam; PF02491; SHS2_FTSA; 1.
DR   PIRSF; PIRSF003101; FtsA; 1.
DR   SMART; SM00842; FtsA; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR01174; ftsA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome.
FT   CHAIN           1..413
FT                   /note="Cell division protein FtsA"
FT                   /id="PRO_0000062730"
FT   CONFLICT        155
FT                   /note="E -> G (in Ref. 2; CAA78155/CAA65463)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   413 AA;  45036 MW;  169D3F54BFF826EE CRC64;
     MSRNLIVGLD VGTSKICTVV AEVNLNDQLE IVGIGTSISR GVRKGVLINI EAALDSISNS
     IEAAELISGC DITSLSVSMS GSSVEGTNSR GVVAINSKTR EINEEDVERV IEAAKAIVIP
     MDREILHVIP QEFIVDGIPH IKNPIDMMGI RLEGEVHIIT GSSSSSQNLV RCVNRAGFAV
     DEVVLGSLAS SYATLSKEER EMGVLFIDMG KGTTDIILYI DGSPYYTGVI PIGVNRVTLD
     IAQVWKVPED VAENIKITAG IAHPSILESQ METVIIPNLG TRPPQEKSRK ELSVIINSRL
     REIFEMMKAE ILKRGLYNKI NGGIVLTGGG ALFPGISNLI EEVFNYPARI GLPMSINGIG
     EEHIDPKFSS ALGLVLYKHE QQKFNKLKKV SSKVKRKNKI SSKLKGWFLK EWF