ID   FTSA_ENTFA              Reviewed;         440 AA.
AC   O07111;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   23-APR-2003, sequence version 2.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Cell division protein FtsA {ECO:0000255|HAMAP-Rule:MF_02033};
GN   Name=ftsA {ECO:0000255|HAMAP-Rule:MF_02033}; OrderedLocusNames=EF_0996;
OS   Enterococcus faecalis (strain ATCC 700802 / V583).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=226185;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A24836;
RX   PubMed=9287029; DOI=10.1128/jb.179.17.5632-5635.1997;
RA   Pucci M.J., Thanassi J.A., Discotto L.F., Kessler R.E., Dougherty T.J.;
RT   "Identification and characterization of cell wall-cell division gene
RT   clusters in pathogenic Gram-positive cocci.";
RL   J. Bacteriol. 179:5632-5635(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700802 / V583;
RX   PubMed=12663927; DOI=10.1126/science.1080613;
RA   Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA   Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA   Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA   DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA   Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA   Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT   "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT   faecalis.";
RL   Science 299:2071-2074(2003).
CC   -!- FUNCTION: Cell division protein that is involved in the assembly of the
CC       Z ring. May serve as a membrane anchor for the Z ring.
CC       {ECO:0000255|HAMAP-Rule:MF_02033}.
CC   -!- SUBUNIT: Self-interacts. Interacts with FtsZ. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_02033};
CC       Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_02033};
CC       Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_02033}. Note=Localizes to
CC       the Z ring in an FtsZ-dependent manner. Targeted to the membrane
CC       through a conserved C-terminal amphipathic helix. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
CC   -!- SIMILARITY: Belongs to the FtsA/MreB family. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC45638.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; U94707; AAC45638.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE016830; AAO80802.1; -; Genomic_DNA.
DR   RefSeq; NP_814732.1; NC_004668.1.
DR   RefSeq; WP_002355898.1; NZ_KE136527.1.
DR   AlphaFoldDB; O07111; -.
DR   SMR; O07111; -.
DR   STRING; 226185.EF_0996; -.
DR   DNASU; 1199884; -.
DR   EnsemblBacteria; AAO80802; AAO80802; EF_0996.
DR   GeneID; 60893383; -.
DR   KEGG; efa:EF0996; -.
DR   PATRIC; fig|226185.45.peg.3202; -.
DR   eggNOG; COG0849; Bacteria.
DR   HOGENOM; CLU_037850_1_1_9; -.
DR   OMA; DGIIRHT; -.
DR   Proteomes; UP000001415; Chromosome.
DR   GO; GO:0032153; C:cell division site; IEA:UniProtKB-UniRule.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_02033; FtsA; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR020823; Cell_div_FtsA.
DR   InterPro; IPR021873; FtsA_C.
DR   InterPro; IPR003494; SHS2_FtsA.
DR   Pfam; PF11983; DUF3484; 1.
DR   Pfam; PF02491; SHS2_FTSA; 1.
DR   PIRSF; PIRSF003101; FtsA; 1.
DR   SMART; SM00842; FtsA; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR01174; ftsA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Membrane; Reference proteome.
FT   CHAIN           1..440
FT                   /note="Cell division protein FtsA"
FT                   /id="PRO_0000062738"
FT   CONFLICT        108
FT                   /note="R -> C (in Ref. 1; AAC45638)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        331..342
FT                   /note="MPGIVDLAQEIF -> IARYCRFRRKRFL (in Ref. 1)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   440 AA;  48178 MW;  6B0AF2A1F6FF2FCE CRC64;
     MAKTGMYVGL DIGTTSVKVV VAEYIEGQMN IIGVGNAKSD GLNRGIVVDI DQTVQAIQRA
     VRQAEEKAGI QIKSVNVGLP ANLLEVESCQ GMIAVSSESK EITDEDVRNV ASAALVRSTP
     PERQIVAILP QDFTVDGFEG IKDPRGMLGV RMEMFGVVYT GPKTIIHNIR KCVEKAGLGI
     NELVITPLAL TETILTDGEK DFGTIVIDMG GGQTTTSVIH DKQLKFTHVN QEGGEFITKD
     ISIVLNTSFN NAEALKINYG DAYPERTSAN EEFPVDVIGK SEPVRVDERY LSEIIEARVE
     QILRKSKEVL DEIDAFELPG GVVLTGGAAS MPGIVDLAQE IFEANVKLYV PNHMGLRNPV
     FANVISIVEY SAQLNDIYHI AKYAIPGEKS KPAQSVAVQQ EVRYDTYAEQ PQEEYEEFNE
     RESGEKVTGK IKDFFSNIFD