ID   FTSA_ENTHR              Reviewed;         442 AA.
AC   O07672;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Cell division protein FtsA {ECO:0000255|HAMAP-Rule:MF_02033};
GN   Name=ftsA {ECO:0000255|HAMAP-Rule:MF_02033};
OS   Enterococcus hirae.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=1354;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=S185;
RX   PubMed=10520745; DOI=10.3109/10425179809072190;
RA   Duez C., Thamm I., Sapunaric F., Coyette J., Ghuysen J.-M.;
RT   "The division and cell wall gene cluster of Enterococcus hirae S185.";
RL   DNA Seq. 9:149-161(1998).
CC   -!- FUNCTION: Cell division protein that is involved in the assembly of the
CC       Z ring. May serve as a membrane anchor for the Z ring.
CC       {ECO:0000255|HAMAP-Rule:MF_02033}.
CC   -!- SUBUNIT: Self-interacts. Interacts with FtsZ. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_02033};
CC       Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_02033};
CC       Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_02033}. Note=Localizes to
CC       the Z ring in an FtsZ-dependent manner. Targeted to the membrane
CC       through a conserved C-terminal amphipathic helix. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
CC   -!- SIMILARITY: Belongs to the FtsA/MreB family. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
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DR   EMBL; Y13922; CAA74237.1; -; Genomic_DNA.
DR   AlphaFoldDB; O07672; -.
DR   SMR; O07672; -.
DR   STRING; 1354.A6P53_03415; -.
DR   GO; GO:0032153; C:cell division site; IEA:UniProtKB-UniRule.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_02033; FtsA; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR020823; Cell_div_FtsA.
DR   InterPro; IPR021873; FtsA_C.
DR   InterPro; IPR003494; SHS2_FtsA.
DR   Pfam; PF11983; DUF3484; 1.
DR   Pfam; PF02491; SHS2_FTSA; 1.
DR   PIRSF; PIRSF003101; FtsA; 1.
DR   SMART; SM00842; FtsA; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR01174; ftsA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Membrane.
FT   CHAIN           1..442
FT                   /note="Cell division protein FtsA"
FT                   /id="PRO_0000062739"
FT   REGION          401..428
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   442 AA;  47955 MW;  5F199A9F4AC5034C CRC64;
     MAKTGMYVGL DIGTTSVKVV VAEYIDSQMN IIGVGNAKSE GINRGIIVDI DKTVQAIQRA
     VRQAEEKAGI QIKGVSVGLP ANLLEVENCQ GMIAVNGDSK EITDEDVRNV ASAALVRSIP
     PERQIVSILP QDFTVDGFEG IKDPRGMIGV RLEMYGLLFT GPKTIVHNIR KCVENAGLVV
     NELVITPLAL TETILSDGEK DFGTIVIDMG GGQTTTAVMH DKQLKFTSLD QEGGEFVTKD
     ISIVLNTSFN NAEALKINYG DAYPERTSAN EEFPVDVIGQ SEPVKVDERY LSEVISARME
     QIFNKAKEAL DQIEALELPG GIVLTGGAAS LPGVVDLAQE IFGVNVKLYV PNQMGLRNPV
     FTNVISIVDY SANLSEVYQL AKIAVTGETV VAHHTTVEQE VTSYDNDSYD APEETVYDEP
     EQKKSDEDVT TKIKGFFSKI FD