ID   FTSA_HAEIN              Reviewed;         425 AA.
AC   P45068;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Cell division protein FtsA {ECO:0000255|HAMAP-Rule:MF_02033};
GN   Name=ftsA {ECO:0000255|HAMAP-Rule:MF_02033}; OrderedLocusNames=HI_1142;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Cell division protein that is involved in the assembly of the
CC       Z ring. May serve as a membrane anchor for the Z ring.
CC       {ECO:0000255|HAMAP-Rule:MF_02033}.
CC   -!- SUBUNIT: Self-interacts. Interacts with FtsZ. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_02033}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_02033}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_02033}.
CC       Note=Localizes to the Z ring in an FtsZ-dependent manner. Targeted to
CC       the membrane through a conserved C-terminal amphipathic helix.
CC       {ECO:0000255|HAMAP-Rule:MF_02033}.
CC   -!- SIMILARITY: Belongs to the FtsA/MreB family. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
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DR   EMBL; L42023; AAC22797.1; -; Genomic_DNA.
DR   PIR; H64185; H64185.
DR   RefSeq; NP_439300.1; NC_000907.1.
DR   RefSeq; WP_005693456.1; NC_000907.1.
DR   AlphaFoldDB; P45068; -.
DR   SMR; P45068; -.
DR   STRING; 71421.HI_1142; -.
DR   DNASU; 950107; -.
DR   EnsemblBacteria; AAC22797; AAC22797; HI_1142.
DR   KEGG; hin:HI_1142; -.
DR   PATRIC; fig|71421.8.peg.1192; -.
DR   eggNOG; COG0849; Bacteria.
DR   HOGENOM; CLU_037850_3_2_6; -.
DR   OMA; DGIIRHT; -.
DR   PhylomeDB; P45068; -.
DR   BioCyc; HINF71421:G1GJ1-1175-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0032153; C:cell division site; IBA:GO_Central.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IBA:GO_Central.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_02033; FtsA; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR020823; Cell_div_FtsA.
DR   InterPro; IPR003494; SHS2_FtsA.
DR   Pfam; PF02491; SHS2_FTSA; 1.
DR   PIRSF; PIRSF003101; FtsA; 1.
DR   SMART; SM00842; FtsA; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR01174; ftsA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome.
FT   CHAIN           1..425
FT                   /note="Cell division protein FtsA"
FT                   /id="PRO_0000062737"
SQ   SEQUENCE   425 AA;  45836 MW;  AF5C4B808D73CE9D CRC64;
     MVKGVETKTI VGLEVGTSKV VVVVGEVFPD GVVNVLGVGS CPSKGIDRGS ITDLDAVVGS
     IQRAIEAAES MADCQIMSVT LAITGEHIQS LNESGFVPIA ESEVTQEEID SALHTASSIK
     LPEGLSLLHV IPQEYAVDRQ MNIKNPLGLQ GVRLKAQVHL IACHQDWQNN LKKAVERCGL
     QVDKVVFSGF AATHSVLTED EKDLGVCLID FGAGTMNVMV YTNGALRFSK VIPYAGNIVT
     NDIAHACTIS RAEAERIKVN YASAFYPARL HGDKKIEVAS IGGRAPRSLT KSDLSLITSA
     RYTELLGVVK DELDKLKAEL EAKHIKFELI AGVVITGGGA QIEDLKECAS NVFHCQVRIA
     SPLNITGLTD YVNRPQYSTV VGLLQYNYSN SDDDLISGSD DSEGTFFESI WQGVKKIVNK
     VRSEF