FTSA_HELPY
ID FTSA_HELPY Reviewed; 492 AA.
AC O25629;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Cell division protein FtsA {ECO:0000255|HAMAP-Rule:MF_02033};
GN Name=ftsA {ECO:0000255|HAMAP-Rule:MF_02033}; OrderedLocusNames=HP_0978;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- FUNCTION: Cell division protein that is involved in the assembly of the
CC Z ring. May serve as a membrane anchor for the Z ring.
CC {ECO:0000255|HAMAP-Rule:MF_02033}.
CC -!- SUBUNIT: Self-interacts. Interacts with FtsZ. {ECO:0000255|HAMAP-
CC Rule:MF_02033}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_02033}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_02033}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_02033}.
CC Note=Localizes to the Z ring in an FtsZ-dependent manner. Targeted to
CC the membrane through a conserved C-terminal amphipathic helix.
CC {ECO:0000255|HAMAP-Rule:MF_02033}.
CC -!- SIMILARITY: Belongs to the FtsA/MreB family. {ECO:0000255|HAMAP-
CC Rule:MF_02033}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE000511; AAD08024.1; -; Genomic_DNA.
DR PIR; B64642; B64642.
DR RefSeq; NP_207769.1; NC_000915.1.
DR RefSeq; WP_000400290.1; NC_018939.1.
DR AlphaFoldDB; O25629; -.
DR SMR; O25629; -.
DR DIP; DIP-3124N; -.
DR IntAct; O25629; 8.
DR MINT; O25629; -.
DR STRING; 85962.C694_05035; -.
DR PaxDb; O25629; -.
DR DNASU; 899510; -.
DR EnsemblBacteria; AAD08024; AAD08024; HP_0978.
DR KEGG; hpy:HP_0978; -.
DR PATRIC; fig|85962.47.peg.1046; -.
DR eggNOG; COG0849; Bacteria.
DR OMA; DGIIRHT; -.
DR PhylomeDB; O25629; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0032153; C:cell division site; IBA:GO_Central.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IBA:GO_Central.
DR GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR HAMAP; MF_02033; FtsA; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR020823; Cell_div_FtsA.
DR InterPro; IPR003494; SHS2_FtsA.
DR Pfam; PF02491; SHS2_FTSA; 1.
DR SMART; SM00842; FtsA; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR TIGRFAMs; TIGR01174; ftsA; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome.
FT CHAIN 1..492
FT /note="Cell division protein FtsA"
FT /id="PRO_0000062740"
FT REGION 288..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 429..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 492 AA; 54493 MW; FA237B467BE39B4A CRC64;
MEHKEIVIGV DLGSRKICAI VAEFKEGILR IIGTAHQDSK EINSKAIKRG RINSLAHASN
AIKEVINSAK KMAGLNADED RNNPMPHFGE YHPKTKAIVS FSGAYTESIR DVTGVASTKD
NVVTIDEINR AINSACAKAG LDNDKHILHA LPYRFTLDKQ EVNDPLGMSG TRLEVFIHIV
YTEKNNIENL EKIMIQSGVE IENIVINSYA ASIATLSNDE RELGVACVDM GGETCNLTIY
SGNSIRYNKY LPVGSHHLTT DLSHMLNTPF PYAEEVKIKY GDLSFEGGEE TPSQNVQIPT
TGSDGHESHI VPLSEIQTIM RERALETFKI IHRSIQDSGL EEHLGGGVVL TGGMALMKGI
KELARTHFTN YPVRLAAPVE KYNIMGMFED LKDPRFSVVV GLILYKAGGH TNYERDSKGV
IRYHESDDYT RTAHQSSPTP HIHSSPTERN LSDLKAPSAP LNTAKNDDFL PIKPTEQKGF
FKSFLDKISK FF
