ID   FTSA_NEIMB              Reviewed;         414 AA.
AC   Q9K0X8;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Cell division protein FtsA {ECO:0000255|HAMAP-Rule:MF_02033};
GN   Name=ftsA {ECO:0000255|HAMAP-Rule:MF_02033}; OrderedLocusNames=NMB0426;
OS   Neisseria meningitidis serogroup B (strain MC58).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC58;
RX   PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA   Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E.,
RA   Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA   Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H.,
RA   Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M.,
RA   Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA   Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V.,
RA   Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA   Moxon E.R., Rappuoli R., Venter J.C.;
RT   "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT   MC58.";
RL   Science 287:1809-1815(2000).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=NZ98/254 / Serogroup B;
RX   PubMed=16645985; DOI=10.1002/pmic.200500821;
RA   Vipond C., Suker J., Jones C., Tang C., Feavers I.M., Wheeler J.X.;
RT   "Proteomic analysis of a meningococcal outer membrane vesicle vaccine
RT   prepared from the group B strain NZ98/254.";
RL   Proteomics 6:3400-3413(2006).
CC   -!- FUNCTION: Cell division protein that is involved in the assembly of the
CC       Z ring. May serve as a membrane anchor for the Z ring.
CC       {ECO:0000255|HAMAP-Rule:MF_02033}.
CC   -!- SUBUNIT: Self-interacts. Interacts with FtsZ. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_02033}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_02033}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_02033}.
CC       Note=Localizes to the Z ring in an FtsZ-dependent manner. Targeted to
CC       the membrane through a conserved C-terminal amphipathic helix.
CC       {ECO:0000255|HAMAP-Rule:MF_02033}.
CC   -!- MISCELLANEOUS: Present in outer membrane vesicle formulations which are
CC       used as vaccines in human.
CC   -!- SIMILARITY: Belongs to the FtsA/MreB family. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
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DR   EMBL; AE002098; AAF40864.1; -; Genomic_DNA.
DR   PIR; E81201; E81201.
DR   RefSeq; NP_273474.1; NC_003112.2.
DR   RefSeq; WP_002216537.1; NC_003112.2.
DR   AlphaFoldDB; Q9K0X8; -.
DR   SMR; Q9K0X8; -.
DR   STRING; 122586.NMB0426; -.
DR   PaxDb; Q9K0X8; -.
DR   EnsemblBacteria; AAF40864; AAF40864; NMB0426.
DR   GeneID; 61281970; -.
DR   KEGG; nme:NMB0426; -.
DR   PATRIC; fig|122586.8.peg.540; -.
DR   HOGENOM; CLU_037850_3_2_4; -.
DR   OMA; DGIIRHT; -.
DR   Proteomes; UP000000425; Chromosome.
DR   GO; GO:0032153; C:cell division site; IBA:GO_Central.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IBA:GO_Central.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_02033; FtsA; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR020823; Cell_div_FtsA.
DR   InterPro; IPR003494; SHS2_FtsA.
DR   Pfam; PF02491; SHS2_FTSA; 1.
DR   PIRSF; PIRSF003101; FtsA; 1.
DR   SMART; SM00842; FtsA; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR01174; ftsA; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome.
FT   CHAIN           1..414
FT                   /note="Cell division protein FtsA"
FT                   /id="PRO_0000320267"
SQ   SEQUENCE   414 AA;  44061 MW;  729655580466026F CRC64;
     MEQQQRYISV LDIGTSKVLA LIGEVQDDDK INIVGLGQAP SRGLRAGMVT NIDATVQAIR
     QAVNDAELMA DTKITHVTTG IAGNHIRSLN SQGVVKIKDG EVTQADIDRA IETAKAINIP
     PDQKILDAVV QDYIIDTQLG VREPIGMSGV RLDTRVHIIT GASTAVQNVQ KCIERCGLKS
     DQIMLQPLAS GQAVLTEDEK DLGVCVIDIG GGTTDIAVYM NGAIRHTSVI PAGGNLITKD
     LSKSLRTPLD AAEYIKIHYG VASCDTEGLG EMIEVPGVGD RTSRQVSSKV LAAIISARIQ
     EIFGVVLGEL QKSGFPKEVL NAGIVLTGGV SMMTGIVEFA EKIFDLPVRT GAPQEMGGLS
     DRVRTPRFST AIGLLHAACK LEGNLPQPEN GAVQEREGGG GLLARLKRWI ENSF