FTSA_PSEAE
ID FTSA_PSEAE Reviewed; 417 AA.
AC P47203;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 08-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Cell division protein FtsA {ECO:0000255|HAMAP-Rule:MF_02033};
GN Name=ftsA {ECO:0000255|HAMAP-Rule:MF_02033}; OrderedLocusNames=PA4408;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RA Levesque R.C., Liao X., Lightfoot J., Charlebois I., Ouellet C.,
RA Morency M., Dewar K., Siehnel R., Lam J., Hancock R.E.;
RT "Physical mapping of 38 loci including aimE, ampC, ampR, arcA, aroK, catR,
RT cypH, dapB, envA, envC, ftsA, ftsZ, groEL, murE, opdE, oprD, oprF, oprH,
RT oprI, oprK, oprP, pbpB, pbpC, pheS, phoA, phoB, phoS, ponA, pyoS1, qin,
RT rpoB, rpoH, sodB, soxR, sucC.";
RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
RN [3]
RP PRELIMINARY NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 184-417.
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=8581173; DOI=10.1099/13500872-142-1-79;
RA Liao X., Charlebois I., Ouellet C., Morency M.J., Dewar K., Lightfoot J.,
RA Foster J., Siehnel R., Schweizer H., Lam J.S., Hancock R.E., Levesque R.C.;
RT "Physical mapping of 32 genetic markers on the Pseudomonas aeruginosa PAO1
RT chromosome.";
RL Microbiology 142:79-86(1996).
CC -!- FUNCTION: Cell division protein that is involved in the assembly of the
CC Z ring. May serve as a membrane anchor for the Z ring.
CC {ECO:0000255|HAMAP-Rule:MF_02033}.
CC -!- SUBUNIT: Self-interacts. Interacts with FtsZ. {ECO:0000255|HAMAP-
CC Rule:MF_02033}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_02033}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_02033}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_02033}.
CC Note=Localizes to the Z ring in an FtsZ-dependent manner. Targeted to
CC the membrane through a conserved C-terminal amphipathic helix.
CC {ECO:0000255|HAMAP-Rule:MF_02033}.
CC -!- SIMILARITY: Belongs to the FtsA/MreB family. {ECO:0000255|HAMAP-
CC Rule:MF_02033}.
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DR EMBL; U19797; AAA95992.2; -; Genomic_DNA.
DR EMBL; AE004091; AAG07796.1; -; Genomic_DNA.
DR PIR; A83094; A83094.
DR RefSeq; NP_253098.1; NC_002516.2.
DR RefSeq; WP_003094115.1; NZ_QZGE01000004.1.
DR AlphaFoldDB; P47203; -.
DR SMR; P47203; -.
DR STRING; 287.DR97_1586; -.
DR PaxDb; P47203; -.
DR PRIDE; P47203; -.
DR DNASU; 881321; -.
DR EnsemblBacteria; AAG07796; AAG07796; PA4408.
DR GeneID; 881321; -.
DR KEGG; pae:PA4408; -.
DR PATRIC; fig|208964.12.peg.4617; -.
DR PseudoCAP; PA4408; -.
DR HOGENOM; CLU_037850_3_2_6; -.
DR InParanoid; P47203; -.
DR OMA; DGIIRHT; -.
DR PhylomeDB; P47203; -.
DR BioCyc; PAER208964:G1FZ6-4495-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0032153; C:cell division site; IBA:GO_Central.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IBA:GO_Central.
DR GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR HAMAP; MF_02033; FtsA; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR020823; Cell_div_FtsA.
DR InterPro; IPR003494; SHS2_FtsA.
DR Pfam; PF02491; SHS2_FTSA; 1.
DR PIRSF; PIRSF003101; FtsA; 1.
DR SMART; SM00842; FtsA; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR TIGRFAMs; TIGR01174; ftsA; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome.
FT CHAIN 1..417
FT /note="Cell division protein FtsA"
FT /id="PRO_0000062743"
SQ SEQUENCE 417 AA; 44646 MW; 3BE2C0CFC785D4E5 CRC64;
MASVQSGKMI VGLDIGTSKV VALVGEVTAD GQLEVVGIGT HPSRGLKKGV VVNIESTVQS
IQRAIDEAQQ MAGCRIHSAF VGIAGNHIRS LNSHGIVAIR DREVNPADIE RVLDAAQAVA
IPADQRVLHT LAQDYVIDNQ EGVREPLGMS GVRLEAKVHV VTCAVNASQN IEKCVRRCGL
EVDDIILEQL ASAYSVLTED EKELGVCLVD IGGGTTDIAI FTEGAIRHTA VIPIAGDQVT
NDIAMALRTP TQYAEEIKIR YACALAKLAG AGETIKVPSV GDRPPRELSR QALAEVVEPR
YDELFTLVQA ELRRSGYEDL IPAGIVLTGG TSKMEGAVEL AEEIFHMPVR LGVPYSVKGL
TDVVRNPIYS TGVGLLMYGL QKQSDGMSMS VSGSSYSSDE PKAPVLERLK RWVQGNF
