ID   FTSA_STAAM              Reviewed;         470 AA.
AC   P63764; Q99US9;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Cell division protein FtsA {ECO:0000255|HAMAP-Rule:MF_02033};
GN   Name=ftsA {ECO:0000255|HAMAP-Rule:MF_02033}; OrderedLocusNames=SAV1185;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Cell division protein that is involved in the assembly of the
CC       Z ring. May serve as a membrane anchor for the Z ring.
CC       {ECO:0000255|HAMAP-Rule:MF_02033}.
CC   -!- SUBUNIT: Self-interacts. Interacts with FtsZ. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_02033};
CC       Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_02033};
CC       Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_02033}. Note=Localizes to
CC       the Z ring in an FtsZ-dependent manner. Targeted to the membrane
CC       through a conserved C-terminal amphipathic helix. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
CC   -!- SIMILARITY: Belongs to the FtsA/MreB family. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
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DR   EMBL; BA000017; BAB57347.1; -; Genomic_DNA.
DR   RefSeq; WP_000391031.1; NC_002758.2.
DR   AlphaFoldDB; P63764; -.
DR   SMR; P63764; -.
DR   World-2DPAGE; 0002:P63764; -.
DR   PaxDb; P63764; -.
DR   EnsemblBacteria; BAB57347; BAB57347; SAV1185.
DR   KEGG; sav:SAV1185; -.
DR   HOGENOM; CLU_037850_1_0_9; -.
DR   OMA; DGIIRHT; -.
DR   PhylomeDB; P63764; -.
DR   BioCyc; SAUR158878:SAV_RS06400-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0032153; C:cell division site; IEA:UniProtKB-UniRule.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_02033; FtsA; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR020823; Cell_div_FtsA.
DR   InterPro; IPR003494; SHS2_FtsA.
DR   Pfam; PF02491; SHS2_FTSA; 1.
DR   PIRSF; PIRSF003101; FtsA; 1.
DR   SMART; SM00842; FtsA; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR01174; ftsA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Membrane.
FT   CHAIN           1..470
FT                   /note="Cell division protein FtsA"
FT                   /id="PRO_0000062747"
FT   REGION          416..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   470 AA;  52935 MW;  5EDEA401E8EB63DF CRC64;
     MEEHYYVSID IGSSSVKTIV GEKFHNGINV IGTGQTYTSG IKNGLIDDFD IARQAIKDTI
     KKASIASGVD IKEVFLKLPI IGTEVYDESN EIDFYEDTEI NGSHIEKVLE GIREKNDVQE
     TEVINVFPIR FIVDKENEVS DPKELIARHS LKVEAGVIAI QKSILINMIK CVEACGVDVL
     DVYSDAYNYG SILTATEKEL GACVIDIGED VTQVAFYERG ELVDADSIEM AGRDITDDIA
     QGLNTSYETA EKVKHQYGHA FYDSASDQDI FTVEQVDSDE TVQYTQKDLS DFIEARVEEI
     FFEVFDVLQD LGLTKVNGGF IVTGGSANLL GVKELLSDMV SEKVRIHTPS QMGIRKPEFS
     SAISTISSSI AFDELLDYVT INYHDNEETE EDVIDVKDKD NESKLGGFDW FKRKTNKKDT
     HENEVESTDE EIYQSEDNHQ EHKQNHEHVQ DKDKDKEESK FKKLMKSLFE