ID   FTSA_STAAR              Reviewed;         468 AA.
AC   Q6GHQ0;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Cell division protein FtsA {ECO:0000255|HAMAP-Rule:MF_02033};
GN   Name=ftsA {ECO:0000255|HAMAP-Rule:MF_02033}; OrderedLocusNames=SAR1161;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Cell division protein that is involved in the assembly of the
CC       Z ring. May serve as a membrane anchor for the Z ring.
CC       {ECO:0000255|HAMAP-Rule:MF_02033}.
CC   -!- SUBUNIT: Self-interacts. Interacts with FtsZ. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
CC   -!- INTERACTION:
CC       Q6GHQ0; Q6GHP9: ftsZ; NbExp=2; IntAct=EBI-9351810, EBI-9351832;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_02033};
CC       Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_02033};
CC       Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_02033}. Note=Localizes to
CC       the Z ring in an FtsZ-dependent manner. Targeted to the membrane
CC       through a conserved C-terminal amphipathic helix. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
CC   -!- SIMILARITY: Belongs to the FtsA/MreB family. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
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DR   EMBL; BX571856; CAG40163.1; -; Genomic_DNA.
DR   RefSeq; WP_000391030.1; NC_002952.2.
DR   PDB; 3WQT; X-ray; 2.20 A; A/B/C/D=1-468.
DR   PDB; 3WQU; X-ray; 2.80 A; A/B/C/D=1-468.
DR   PDBsum; 3WQT; -.
DR   PDBsum; 3WQU; -.
DR   AlphaFoldDB; Q6GHQ0; -.
DR   SMR; Q6GHQ0; -.
DR   IntAct; Q6GHQ0; 1.
DR   MINT; Q6GHQ0; -.
DR   KEGG; sar:SAR1161; -.
DR   HOGENOM; CLU_037850_1_0_9; -.
DR   OMA; DGIIRHT; -.
DR   OrthoDB; 1044637at2; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0032153; C:cell division site; IEA:UniProtKB-UniRule.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_02033; FtsA; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR020823; Cell_div_FtsA.
DR   InterPro; IPR003494; SHS2_FtsA.
DR   Pfam; PF02491; SHS2_FTSA; 1.
DR   PIRSF; PIRSF003101; FtsA; 1.
DR   SMART; SM00842; FtsA; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR01174; ftsA; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell cycle; Cell division; Cell membrane; Membrane.
FT   CHAIN           1..468
FT                   /note="Cell division protein FtsA"
FT                   /id="PRO_0000062749"
FT   REGION          416..468
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   STRAND          6..11
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   STRAND          13..24
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   STRAND          27..37
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   STRAND          39..42
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   STRAND          45..48
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   HELIX           49..67
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   STRAND          73..78
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   STRAND          80..93
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   HELIX           102..112
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   STRAND          121..133
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   TURN            134..136
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   STRAND          137..140
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   STRAND          146..161
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   HELIX           162..173
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   TURN            174..176
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   STRAND          178..184
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   HELIX           185..188
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   HELIX           189..192
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   HELIX           195..200
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   STRAND          202..207
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   STRAND          212..218
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   STRAND          221..229
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   HELIX           232..242
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   HELIX           247..257
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   HELIX           262..264
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   STRAND          270..274
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   STRAND          276..279
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   STRAND          281..285
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   HELIX           286..310
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   STRAND          319..324
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   HELIX           325..328
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   HELIX           332..337
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   STRAND          340..342
FT                   /evidence="ECO:0007829|PDB:3WQU"
FT   STRAND          344..346
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   STRAND          350..353
FT                   /evidence="ECO:0007829|PDB:3WQU"
FT   HELIX           357..359
FT                   /evidence="ECO:0007829|PDB:3WQT"
FT   HELIX           360..376
FT                   /evidence="ECO:0007829|PDB:3WQT"
SQ   SEQUENCE   468 AA;  52677 MW;  B78B4B26847DC3C4 CRC64;
     MEEHYYVSID IGSSSVKTIV GEKFHNGINV IGTGQTYTSG IKNGLIDDFD IARQAIKDTI
     KKASIASGVD IKEVFLKLPI IGTEVYDESN EIDFYEDTEI NGSHIEKVLE GIREKNDVQE
     TEVINVFPIR FIVDKENEVS DPKELIARHS LKVEAGVIAI QKSILINMIK CVEACGVDVL
     DVYSDAYNYG SILTATEKEL GACVIDIGED VTQVAFYERG ELVDADSIEM AGRDITDDIA
     QGLNTSYETA EKVKHQYGHA FYDSASDQDI FTVEQVDSDE TVQYTQKDLS DFIEARVEEI
     FFEVFDVLQD LGLTKVNGGF IVTGGSANLL GVKELLSDMV SEKVRIHTPS QMGIRKPEFS
     SAISTISSSI AFDELLDYVT INYHDNEETE EDVIDVKDKD NESKLGGFDW FKRKTNKKDT
     HENEVESSDE EIYQSEDNHQ EHKQNHEHVQ DKDKEESKFK KLMKSLFE