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FTSA_STAEQ
ID   FTSA_STAEQ              Reviewed;         464 AA.
AC   Q5HQ07;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Cell division protein FtsA {ECO:0000255|HAMAP-Rule:MF_02033};
GN   Name=ftsA {ECO:0000255|HAMAP-Rule:MF_02033}; OrderedLocusNames=SERP0750;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Cell division protein that is involved in the assembly of the
CC       Z ring. May serve as a membrane anchor for the Z ring.
CC       {ECO:0000255|HAMAP-Rule:MF_02033}.
CC   -!- SUBUNIT: Self-interacts. Interacts with FtsZ. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_02033};
CC       Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_02033};
CC       Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_02033}. Note=Localizes to
CC       the Z ring in an FtsZ-dependent manner. Targeted to the membrane
CC       through a conserved C-terminal amphipathic helix. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
CC   -!- SIMILARITY: Belongs to the FtsA/MreB family. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
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DR   EMBL; CP000029; AAW54138.1; -; Genomic_DNA.
DR   RefSeq; WP_002446229.1; NC_002976.3.
DR   AlphaFoldDB; Q5HQ07; -.
DR   SMR; Q5HQ07; -.
DR   STRING; 176279.SERP0750; -.
DR   EnsemblBacteria; AAW54138; AAW54138; SERP0750.
DR   KEGG; ser:SERP0750; -.
DR   eggNOG; COG0849; Bacteria.
DR   HOGENOM; CLU_037850_1_0_9; -.
DR   OMA; DGIIRHT; -.
DR   OrthoDB; 1044637at2; -.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0032153; C:cell division site; IEA:UniProtKB-UniRule.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_02033; FtsA; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR020823; Cell_div_FtsA.
DR   InterPro; IPR003494; SHS2_FtsA.
DR   Pfam; PF02491; SHS2_FTSA; 1.
DR   PIRSF; PIRSF003101; FtsA; 1.
DR   SMART; SM00842; FtsA; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR01174; ftsA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Membrane; Reference proteome.
FT   CHAIN           1..464
FT                   /note="Cell division protein FtsA"
FT                   /id="PRO_0000062754"
FT   REGION          392..464
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        396..464
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   464 AA;  52056 MW;  2E14A9724B1DF66B CRC64;
     MEEHYYVSID IGSSSVKTIV GEKFHNGINV IGTGQTYTSG IKNGLIDDFD IARQAIKDTI
     KKASIASGVD IKDVFLKLPI IGTEVYDESN EIEFYEDTEI DGTHIESVLE GIRDKNDVPE
     TEVINVFPIR FVVDKDNEVS DPKELIARHS LKVDAGVIAI QKSILINMIK CVEACGVDVL
     DVYSDAYNYG SILTPTEKEL GACVIDIGED LTQVAFYERG ELVDAESIEM AGRDITDDIA
     QGLNTTYDTA EKVKHQYGHA FYDSASDQDV FSVDQVDSDE HVQYTQKDLS DFIEQRVEDI
     FFEVFDVLQE LGLTKVNGGF VVTGGSANLL GVKELLQDMV SEKVRIHTPS QMGIRKPEFS
     SAISTISSSI AFDELLDYVT ISYQDNEEFE EEVIESDKDS ETKSSGFDWF KRKSNKKEND
     EVAPEAPREE SYEDRENHLE DEQQTEGKAK EESKFKKLMK SLFE
 
 
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