ID   FTSA_STAES              Reviewed;         464 AA.
AC   Q8CPK5;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Cell division protein FtsA {ECO:0000255|HAMAP-Rule:MF_02033};
GN   Name=ftsA {ECO:0000255|HAMAP-Rule:MF_02033}; OrderedLocusNames=SE_0860;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Cell division protein that is involved in the assembly of the
CC       Z ring. May serve as a membrane anchor for the Z ring.
CC       {ECO:0000255|HAMAP-Rule:MF_02033}.
CC   -!- SUBUNIT: Self-interacts. Interacts with FtsZ. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_02033};
CC       Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_02033};
CC       Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_02033}. Note=Localizes to
CC       the Z ring in an FtsZ-dependent manner. Targeted to the membrane
CC       through a conserved C-terminal amphipathic helix. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
CC   -!- SIMILARITY: Belongs to the FtsA/MreB family. {ECO:0000255|HAMAP-
CC       Rule:MF_02033}.
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DR   EMBL; AE015929; AAO04457.1; -; Genomic_DNA.
DR   RefSeq; NP_764415.1; NC_004461.1.
DR   RefSeq; WP_001830115.1; NZ_WBME01000036.1.
DR   AlphaFoldDB; Q8CPK5; -.
DR   SMR; Q8CPK5; -.
DR   STRING; 176280.SE_0860; -.
DR   EnsemblBacteria; AAO04457; AAO04457; SE_0860.
DR   KEGG; sep:SE_0860; -.
DR   PATRIC; fig|176280.10.peg.833; -.
DR   eggNOG; COG0849; Bacteria.
DR   HOGENOM; CLU_037850_1_0_9; -.
DR   OMA; DGIIRHT; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0032153; C:cell division site; IEA:UniProtKB-UniRule.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_02033; FtsA; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR020823; Cell_div_FtsA.
DR   InterPro; IPR003494; SHS2_FtsA.
DR   Pfam; PF02491; SHS2_FTSA; 1.
DR   PIRSF; PIRSF003101; FtsA; 1.
DR   SMART; SM00842; FtsA; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR01174; ftsA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Membrane.
FT   CHAIN           1..464
FT                   /note="Cell division protein FtsA"
FT                   /id="PRO_0000062753"
FT   REGION          392..464
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        396..464
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   464 AA;  52144 MW;  37DD0E1D2B16B69A CRC64;
     MEEHYYVSID IGSSSVKTIV GEKFHNGINV IGTGQTYTSG IKNGLIDDFD IARQAIKDTI
     KKASIASGVD IKDVFLKLPI IGTEVYDESN EIEFYEDTEI DGTHIESVLE GIRDKNDVPE
     TEVINVFPIR FVVDKDNEVS DPKELIARHS LKVDAGVIAI QKSILINMIK CVEACGVDVL
     DVYSDAYNYG FILTPTEKEL GACVIDIGED LTQVAFYERG ELVDAESIEM AGRDITDDIA
     QGLNTTYDTA EKVKHQYGHA FYDSASDQDV FSVDQVDSDE HVQYTQKDLS DFIEQRVEDI
     FFEVFDVLQE LGLTKVNGGF VVTGGSANLL GVKELLQDMV SEKVRIHTPS QMGIRKPEFS
     SAISTISSSI AFDELLDYVT ISYQDNEEFE EEVIETDKDT ETKSSGFDWF KRKSNKKEND
     EVAPEAPREE SYEDRENHLE DEQQTEGKAK EESKFKKLMK SLFE