ID   ALF1_CHLPN              Reviewed;         349 AA.
AC   Q9Z8Q7; Q9JQ77;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Probable fructose-bisphosphate aldolase class 1;
DE            EC=4.1.2.13;
DE   AltName: Full=Probable fructose-bisphosphate aldolase class I;
DE            Short=FBP aldolase;
GN   Name=fbaB; OrderedLocusNames=CPn_0281, CP_0477, CpB0289;
OS   Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=83558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CWL029;
RX   PubMed=10192388; DOI=10.1038/7716;
RA   Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA   Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT   "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL   Nat. Genet. 21:385-389(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR39;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J138;
RX   PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA   Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA   Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT   "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT   Japan and CWL029 from USA.";
RL   Nucleic Acids Res. 28:2311-2314(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TW-183;
RA   Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA   Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT   "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT   other Chlamydia strains based on whole genome sequence analysis.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-
CC         phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:14729,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776; EC=4.1.2.13;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DeoC/FbaB aldolase family. FbaB subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE001363; AAD18430.1; -; Genomic_DNA.
DR   EMBL; AE002161; AAF38310.1; -; Genomic_DNA.
DR   EMBL; BA000008; BAA98491.1; -; Genomic_DNA.
DR   EMBL; AE009440; AAP98222.1; -; Genomic_DNA.
DR   PIR; A86526; A86526.
DR   PIR; C72097; C72097.
DR   RefSeq; NP_224486.1; NC_000922.1.
DR   RefSeq; WP_010882929.1; NZ_LN847257.1.
DR   AlphaFoldDB; Q9Z8Q7; -.
DR   SMR; Q9Z8Q7; -.
DR   STRING; 115711.CP_0477; -.
DR   EnsemblBacteria; AAD18430; AAD18430; CPn_0281.
DR   EnsemblBacteria; AAF38310; AAF38310; CP_0477.
DR   GeneID; 45050330; -.
DR   KEGG; cpa:CP_0477; -.
DR   KEGG; cpj:dhnA; -.
DR   KEGG; cpn:CPn_0281; -.
DR   KEGG; cpt:CpB0289; -.
DR   PATRIC; fig|115713.3.peg.315; -.
DR   eggNOG; COG1830; Bacteria.
DR   HOGENOM; CLU_057069_0_0_0; -.
DR   OMA; FVKVNYP; -.
DR   OrthoDB; 1560751at2; -.
DR   Proteomes; UP000000583; Chromosome.
DR   Proteomes; UP000000801; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004332; F:fructose-bisphosphate aldolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR   CDD; cd00958; DhnA; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR   InterPro; IPR041720; FbaB-like.
DR   Pfam; PF01791; DeoC; 1.
DR   SMART; SM01133; DeoC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Glycolysis; Lyase; Schiff base.
FT   CHAIN           1..349
FT                   /note="Probable fructose-bisphosphate aldolase class 1"
FT                   /id="PRO_0000138942"
FT   ACT_SITE        237
FT                   /note="Schiff-base intermediate with dihydroxyacetone-P"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   349 AA;  38028 MW;  69882529D685C7D9 CRC64;
     MLNIHDILGN DDENLLSYQC KHITKDKLTL PSHDFVDKVF GLSDRNNRVL RSLQTMFSHG
     RLANSGYLSI LPVDQGIEHS AGASFAINPI YFDPENIVKL AIESGCSAVA STYGTLSLLS
     RKYAHKIPFM LKLNHNELLS YPTKYHQIFF TQVEAAYSMG AVAVGATVYF GSETSNEEIV
     AVSNAFAKAR SLGLATVLWC YLRNPAFVAN GVDYHTAADL TGQADHLGAT LGADIVKQKL
     PTCQGGFKAI NFGKTDERVY SELSSNHPID LCRYQVLNSY CGKVGLINSG GPSGKNDFTE
     AARTAVINKR AGGMGLILGR KAFQRPLSEG IQLLNLVQDI YLDPNITIA