FTSH6_ORYSJ
ID FTSH6_ORYSJ Reviewed; 686 AA.
AC Q67WJ2; A3B9W9;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=ATP-dependent zinc metalloprotease FTSH 6, chloroplastic;
DE Short=OsFTSH6;
DE EC=3.4.24.-;
DE Flags: Precursor;
GN Name=FTSH6; OrderedLocusNames=Os06g0229066, LOC_Os06g12370;
GN ORFNames=OsJ_019841, P0425F05.40, P0525F01.10;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16040665; DOI=10.1104/pp.105.061234;
RA Yu F., Park S., Rodermel S.R.;
RT "Functional redundancy of AtFtsH metalloproteases in thylakoid membrane
RT complexes.";
RL Plant Physiol. 138:1957-1966(2005).
CC -!- FUNCTION: Probable ATP-dependent zinc metallopeptidase. {ECO:0000250}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane
CC {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Stromal side
CC {ECO:0000250}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the AAA ATPase
CC family. {ECO:0000305}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the peptidase M41
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAZ36358.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AP003509; BAD37263.1; -; Genomic_DNA.
DR EMBL; AP003569; BAD37477.1; -; Genomic_DNA.
DR EMBL; AP014962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM000143; EAZ36358.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_015641788.1; XM_015786302.1.
DR AlphaFoldDB; Q67WJ2; -.
DR SMR; Q67WJ2; -.
DR STRING; 4530.OS06T0229066-00; -.
DR MEROPS; M41.019; -.
DR PaxDb; Q67WJ2; -.
DR PRIDE; Q67WJ2; -.
DR GeneID; 4340563; -.
DR KEGG; osa:4340563; -.
DR eggNOG; KOG0731; Eukaryota.
DR HOGENOM; CLU_000688_21_16_1; -.
DR InParanoid; Q67WJ2; -.
DR OrthoDB; 217929at2759; -.
DR Proteomes; UP000000763; Chromosome 6.
DR Proteomes; UP000007752; Chromosome 6.
DR Proteomes; UP000059680; Chromosome 6.
DR GO; GO:0009534; C:chloroplast thylakoid; IBA:GO_Central.
DR GO; GO:0009535; C:chloroplast thylakoid membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR Gene3D; 1.20.58.760; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01458; FtsH; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR005936; FtsH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000642; Peptidase_M41.
DR InterPro; IPR037219; Peptidase_M41-like.
DR InterPro; IPR006311; TAT_signal.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF01434; Peptidase_M41; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF140990; SSF140990; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR01241; FtsH_fam; 1.
DR PROSITE; PS00674; AAA; 1.
DR PROSITE; PS51318; TAT; 1.
PE 3: Inferred from homology;
KW ATP-binding; Chloroplast; Hydrolase; Membrane; Metal-binding;
KW Metalloprotease; Nucleotide-binding; Plastid; Protease; Reference proteome;
KW Thylakoid; Transit peptide; Transmembrane; Transmembrane helix; Zinc.
FT TRANSIT 1..75
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT TRANSIT 76..?
FT /note="Thylakoid"
FT /evidence="ECO:0000255"
FT CHAIN ?..686
FT /note="ATP-dependent zinc metalloprotease FTSH 6,
FT chloroplastic"
FT /id="PRO_0000341342"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 484
FT /evidence="ECO:0000250"
FT BINDING 261..268
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 483
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 487
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 562
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT CONFLICT 512
FT /note="R -> P (in Ref. 3; EAZ36358)"
FT /evidence="ECO:0000305"
FT CONFLICT 521
FT /note="E -> K (in Ref. 3; EAZ36358)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 686 AA; 72624 MW; E00E8E1A73D49D3B CRC64;
MSPTAMSLTT TTSRLPICRA QGGGVAKEKR TTPPPAKITP PSSSSSEAAG LSRRRLLQSA
GLGLGLGLTA ARPARAEATA PEEVTSNRMS YSRFLEYLDA GAVKKVDFFE NGTVAVAEVD
DAAALSRVHR VKVQLPGLPA ELVRKLRDKG VDFAAHPVEP SAGVMLLDLL VNFGFPLLFV
ASLLWRSPTM NNPGGGPSLP FGLGKSKAKF QMEPKTGVTF DDVAGVDEAK QDFQEIVQFL
KFPEKFTAVG ARTPKGVLLV GPPGTGKTLL AKAIAGEAGV PFFSLSGSEF IEMFVGVGAS
RVRDLFDRAK ASAPCLVFID EIDAVGRQRG AGIGGGNDER EQTLNQLLTE MDGFGGGDGG
VVVIAATNRP EILDAALLRP GRFDRRVSVG LPDVRGREEI LLVHGANKRL DPGVSLAVVA
MRTPGFSGAD LANLMNEAAI LAGRRGKDRI TVSEIDDSID RIVAGLEGTS MTDGKSKMLV
AYHEIGHAVC ATLTAGHDEV QKVTLIPRGQ ARGLTWFLPG EEDPALVSRQ QIFAGIVGGL
GGRAAEEVVF GEPEVTTGAA GDLQQVTRVA RRMVTAFGMS EIGPWALAEP AAQGGDVVLR
MLARSSMSER LAADIDAAVR TIVDEAYEVA KAHVRRNRAA IDQLVDVLME KETLGGDEFR
AILSEHVDIG KERRETAART QQLATA
