ID   FTSHL_HAEIN             Reviewed;         381 AA.
AC   P45219;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=ATP-dependent zinc metalloprotease FtsH homolog;
GN   OrderedLocusNames=HI_1465;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000305};
CC   -!- SIMILARITY: In the N-terminal section; belongs to the AAA ATPase
CC       family. {ECO:0000305}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the peptidase M41
CC       family. {ECO:0000305}.
CC   -!- CAUTION: Missing the N-terminal trans-membrane domains found in
CC       paralogs. {ECO:0000305}.
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DR   EMBL; L42023; AAC23112.1; -; Genomic_DNA.
DR   PIR; B64125; B64125.
DR   RefSeq; NP_439616.1; NC_000907.1.
DR   AlphaFoldDB; P45219; -.
DR   SMR; P45219; -.
DR   STRING; 71421.HI_1465; -.
DR   MEROPS; M41.001; -.
DR   EnsemblBacteria; AAC23112; AAC23112; HI_1465.
DR   KEGG; hin:HI_1465; -.
DR   PATRIC; fig|71421.8.peg.1531; -.
DR   eggNOG; COG0465; Bacteria.
DR   HOGENOM; CLU_000688_9_4_6; -.
DR   OMA; TEMANMQ; -.
DR   PhylomeDB; P45219; -.
DR   BioCyc; HINF71421:G1GJ1-1491-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0004176; F:ATP-dependent peptidase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0030163; P:protein catabolic process; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR   Gene3D; 1.20.58.760; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR041569; AAA_lid_3.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR005936; FtsH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000642; Peptidase_M41.
DR   InterPro; IPR037219; Peptidase_M41-like.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF17862; AAA_lid_3; 1.
DR   Pfam; PF01434; Peptidase_M41; 1.
DR   SUPFAM; SSF140990; SSF140990; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01241; FtsH_fam; 1.
DR   PROSITE; PS00674; AAA; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome;
KW   Zinc.
FT   CHAIN           1..381
FT                   /note="ATP-dependent zinc metalloprotease FtsH homolog"
FT                   /id="PRO_0000084634"
FT   REGION          339..381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        349..381
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         159
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255"
FT   BINDING         163
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255"
FT   BINDING         237
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   381 AA;  42106 MW;  CF689D40B15F7EE0 CRC64;
     MGRQRGAGLG GGHDEREQTL NQMLVEMDGF SGNDGVIVIA ATNRPDVLDP ALTRPGRFDR
     QVVVGLPDVK GREQILKVHM RKVSVAQDVD AMTLARGTPG YSGADLANLV NEAALFAARV
     NKRTVTMLEF EKAKDKINMG PERRTMIMTD KQKESTAYHE AGHAIVGYLV PEHDPVHKVT
     IIPRGRALGV TFFLPEGDQI SISQKQLESK LSTLYAGRLA EDLIYGEENI STGASNDIKV
     ATNIARNMVT QWGFSEKLGP ILYTEDEGEV FLGRSMAKAK HMSDETAHSI DEEVRAIVNR
     NYARAREILI DNMDILHAMK DALVKYETIE EEQIKQLMNR EPVTPPSGWG EPKTQQAAYA
     NSTTNDTKPE SAVENTDDFN V