FTSK_CALS4
ID FTSK_CALS4 Reviewed; 709 AA.
AC Q8R5S4;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=DNA translocase FtsK;
GN Name=ftsK; OrderedLocusNames=TTE1378;
OS Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM
OS 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis).
OC Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Caldanaerobacter.
OX NCBI_TaxID=273068;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15242 / JCM 11007 / NBRC 100824 / MB4;
RX PubMed=11997336; DOI=10.1101/gr.219302;
RA Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y.,
RA Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R.,
RA Wang J., Yu J., Yang H.;
RT "A complete sequence of the T. tengcongensis genome.";
RL Genome Res. 12:689-700(2002).
CC -!- FUNCTION: Essential cell division protein that coordinates cell
CC division and chromosome segregation. The N-terminus is involved in
CC assembly of the cell-division machinery. The C-terminus functions as a
CC DNA motor that moves dsDNA in an ATP-dependent manner towards the dif
CC recombination site, which is located within the replication terminus
CC region. Required for activation of the Xer recombinase, allowing
CC activation of chromosome unlinking by recombination (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homohexamer. Forms a ring that surrounds DNA (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Note=Located at the septum. {ECO:0000250}.
CC -!- DOMAIN: Consists of an N-terminal domain, which is sufficient for the
CC localization to the septal ring and is required for cell division,
CC followed by a linker domain, and a C-terminal domain, which forms the
CC translocation motor involved in chromosome segregation. The C-terminal
CC domain can be further subdivided into alpha, beta and gamma subdomains.
CC The alpha and beta subdomains form the DNA pump, and the gamma
CC subdomain is a regulatory subdomain (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family. {ECO:0000305}.
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DR EMBL; AE008691; AAM24600.1; -; Genomic_DNA.
DR RefSeq; WP_011025666.1; NC_003869.1.
DR AlphaFoldDB; Q8R5S4; -.
DR SMR; Q8R5S4; -.
DR STRING; 273068.TTE1378; -.
DR EnsemblBacteria; AAM24600; AAM24600; TTE1378.
DR KEGG; tte:TTE1378; -.
DR eggNOG; COG1674; Bacteria.
DR HOGENOM; CLU_001981_9_2_9; -.
DR OMA; NEMTERY; -.
DR OrthoDB; 349533at2; -.
DR Proteomes; UP000000555; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR025199; FtsK_4TM.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF13491; FtsK_4TM; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell cycle; Cell division; Cell membrane;
KW Chromosome partition; DNA-binding; Membrane; Nucleotide-binding;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..709
FT /note="DNA translocase FtsK"
FT /id="PRO_0000098312"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..709
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 376..563
FT /note="FtsK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT BINDING 396..401
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 709 AA; 78916 MW; BC76C0B84F0A4E7F CRC64;
MIDKKQKPVK EEIVGIIFLA FTLISFLSLY TDSTGIIGKH IGIFLKGFFG TGSYVISALL
LVFALMFLFT NKNFIKLHRS MALLGLFLMF ISLNQLYYFP VLTDFKDYLS VAYISGINNT
GGGIIGSLIV YFLVKMVGII GSYILLISFT AIFIVLITDI SLVSLIKSSY DKLKDRKKVS
AKNKLQDKMA EKKAEEVEST EELVEVEKKE RIDVPIEIVE QVEEERKVYE KAFLEKEEGE
YTPPPITLLK EAIPSPKIKN EVLLEKAKKI EETLRNFGIE AKVVQVTKGP AITRFELQPS
AGVKVSRIVS LTDDLALSLA APSVRIEAPI PGKSAIGIEV PNEKITPVYL REVIDSKKFR
SFKSELAIGL GKDIAGNIVI ADLAKMPHLL IAGATGSGKS VCINSLIVSL LYKASPKQVK
MILIDPKVVE LNIYNGIPHL LTPVVTDPKK AAGVLNWAVQ EMIRRYSLFA DHGVRDIESY
NEKYKEERLY KIVIIIDELS DLMMVSPAEV EEYIFRLAQM ARAAGIHLVI ATQRPSVDVI
TGVIKANIPS RISFAVSSQI DSRTILDMTG AEKLLGKGDM LFDPIGASKP IRVQGAFISE
EEVEAVVNFL KENYSSHYEE IKVEEKTNGK NLDEEEDELL EDAVSVILET GQASISLLQR
KLRIGYARAA RIIDQLEQKG IISGYDGAKP RQIILPREEI QKILERKSV
