FTSK_CHLPN
ID FTSK_CHLPN Reviewed; 806 AA.
AC Q9Z726;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=DNA translocase FtsK;
GN Name=ftsK; OrderedLocusNames=CPn_0880, CP_0989, CpB0909;
OS Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=83558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP INDUCTION.
RX PubMed=11500413; DOI=10.1128/iai.69.9.5423-5429.2001;
RA Byrne G.I., Ouellette S.P., Wang Z., Rao J.P., Lu L., Beatty W.L.,
RA Hudson A.P.;
RT "Chlamydia pneumoniae expresses genes required for DNA replication but not
RT cytokinesis during persistent infection of HEp-2 cells.";
RL Infect. Immun. 69:5423-5429(2001).
CC -!- FUNCTION: Essential cell division protein that coordinates cell
CC division and chromosome segregation. The N-terminus is involved in
CC assembly of the cell-division machinery. The C-terminus functions as a
CC DNA motor that moves dsDNA in an ATP-dependent manner towards the dif
CC recombination site, which is located within the replication terminus
CC region. Required for activation of the Xer recombinase, allowing
CC activation of chromosome unlinking by recombination (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homohexamer. Forms a ring that surrounds DNA (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Note=Located at the septum.
CC {ECO:0000250}.
CC -!- INDUCTION: During infection of human HEp-2 cells, it is strongly down-
CC regulated by IFN-gamma cytokine. {ECO:0000269|PubMed:11500413}.
CC -!- DOMAIN: Consists of an N-terminal domain, which is sufficient for the
CC localization to the septal ring and is required for cell division,
CC followed by a linker domain, and a C-terminal domain, which forms the
CC translocation motor involved in chromosome segregation. The C-terminal
CC domain can be further subdivided into alpha, beta and gamma subdomains.
CC The alpha and beta subdomains form the DNA pump, and the gamma
CC subdomain is a regulatory subdomain (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family. {ECO:0000305}.
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DR EMBL; AE001363; AAD19018.1; -; Genomic_DNA.
DR EMBL; AE002161; AAF38768.1; -; Genomic_DNA.
DR EMBL; BA000008; BAA99088.1; -; Genomic_DNA.
DR EMBL; AE009440; AAP98838.1; -; Genomic_DNA.
DR PIR; F72024; F72024.
DR PIR; F86600; F86600.
DR RefSeq; NP_225075.1; NC_000922.1.
DR RefSeq; WP_010883515.1; NZ_LN847257.1.
DR AlphaFoldDB; Q9Z726; -.
DR SMR; Q9Z726; -.
DR STRING; 115711.CP_0989; -.
DR EnsemblBacteria; AAD19018; AAD19018; CPn_0880.
DR EnsemblBacteria; AAF38768; AAF38768; CP_0989.
DR GeneID; 45050933; -.
DR KEGG; cpa:CP_0989; -.
DR KEGG; cpj:ftsK; -.
DR KEGG; cpn:CPn_0880; -.
DR KEGG; cpt:CpB0909; -.
DR PATRIC; fig|115713.3.peg.960; -.
DR eggNOG; COG1674; Bacteria.
DR HOGENOM; CLU_001981_9_7_0; -.
DR OrthoDB; 349533at2; -.
DR Proteomes; UP000000583; Chromosome.
DR Proteomes; UP000000801; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR025199; FtsK_4TM.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF13491; FtsK_4TM; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Cell cycle; Cell division; Cell inner membrane; Cell membrane;
KW Chromosome partition; DNA-binding; Membrane; Nucleotide-binding;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..806
FT /note="DNA translocase FtsK"
FT /id="PRO_0000098248"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..806
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 468..667
FT /note="FtsK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT BINDING 488..493
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 806 AA; 89886 MW; AA9ED8B2CF9D5D72 CRC64;
MIRERKKSRH PRLPTLPLAA KASLYLFFAC FSGLSLWSFH RDQPCTQNWI GLLGWSFSSF
LLYFFGAAAF FIPLYFLWLS FLYFRRTPRP LFFYKAAAFL SLPFCSAILL SMLSPVGTLP
ALLDTRLPKF ILGNNPPVSY VGGIPFYLFY EGQSFCLKHL IGSVGTALIF GFVMLFSVLY
LCGGIALLKK KTFQDGVKKA FCSFFQTCFK NLKKLINRRN YLPKPSVPFV SKNPFSCTKS
QPSPRRVSET IILDGSISPL PQEEIPGSKK ESFFLTPHPC KRFLTKFVEP QENKAKEGKT
IALSSTPTVV RESKGKERAA LPKLKSLAVP ENDLPQYHLL SKNREARPES LQAELERKAL
ILKQTLTSFG IDADLGNICS GPTLAAFEVL PHSGVKVQKI KSLENDIALK LQASSIRIIA
PIPGKAAVGI EIPTPFPQAV NFRDLLEDYQ KTNRKLQIPL LLGKKANGDN LWADLATMPH
LIIAGTTGSG KSVCINTIVM SMIMTTLPSE IKLVIIDPKK VELTGYSQLP HMLSPVITES
REVYNALVWL VKEMESRYEI LRYLGLRNIQ AFNSRTRNKT IEASYDREIR ETMPFMVGII
DELSDLLLSS SQDIETPIIR LAQMARAVGI HLILATQRPS REVITGLIKA NFPSRISFKV
SNKVNSQIII DEPGAENLMG NGDMLVLLPS VFGTIRAQGA YICDEDINKV IQDLCSRFPT
QYVIPSFHAF DDSDSDNSGE KDPLFAQAKT LILQTGNAST TFLQRKLKIG YARAASLIDQ
LEEARIIGPS EGAKPRQILI QNPLEG
