FTSK_CLOAB
ID FTSK_CLOAB Reviewed; 765 AA.
AC Q97I41;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=DNA translocase FtsK;
GN Name=ftsK; OrderedLocusNames=CA_C1812;
OS Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710
OS / VKM B-1787).
OC Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=272562;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
RX PubMed=11466286; DOI=10.1128/jb.183.16.4823-4838.2001;
RA Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R.,
RA Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F.,
RA Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V.,
RA Smith D.R.;
RT "Genome sequence and comparative analysis of the solvent-producing
RT bacterium Clostridium acetobutylicum.";
RL J. Bacteriol. 183:4823-4838(2001).
CC -!- FUNCTION: Essential cell division protein that coordinates cell
CC division and chromosome segregation. The N-terminus is involved in
CC assembly of the cell-division machinery. The C-terminus functions as a
CC DNA motor that moves dsDNA in an ATP-dependent manner towards the dif
CC recombination site, which is located within the replication terminus
CC region. Required for activation of the Xer recombinase, allowing
CC activation of chromosome unlinking by recombination (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homohexamer. Forms a ring that surrounds DNA (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Note=Located at the septum. {ECO:0000250}.
CC -!- DOMAIN: Consists of an N-terminal domain, which is sufficient for the
CC localization to the septal ring and is required for cell division,
CC followed by a linker domain, and a C-terminal domain, which forms the
CC translocation motor involved in chromosome segregation. The C-terminal
CC domain can be further subdivided into alpha, beta and gamma subdomains.
CC The alpha and beta subdomains form the DNA pump, and the gamma
CC subdomain is a regulatory subdomain (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family. {ECO:0000305}.
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DR EMBL; AE001437; AAK79777.1; -; Genomic_DNA.
DR PIR; F97123; F97123.
DR RefSeq; NP_348437.1; NC_003030.1.
DR RefSeq; WP_010965118.1; NC_003030.1.
DR AlphaFoldDB; Q97I41; -.
DR SMR; Q97I41; -.
DR STRING; 272562.CA_C1812; -.
DR EnsemblBacteria; AAK79777; AAK79777; CA_C1812.
DR GeneID; 44998306; -.
DR KEGG; cac:CA_C1812; -.
DR PATRIC; fig|272562.8.peg.2018; -.
DR eggNOG; COG1674; Bacteria.
DR HOGENOM; CLU_001981_9_6_9; -.
DR OMA; NEMTRRY; -.
DR OrthoDB; 349533at2; -.
DR Proteomes; UP000000814; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell cycle; Cell division; Cell membrane;
KW Chromosome partition; DNA-binding; Membrane; Nucleotide-binding;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..765
FT /note="DNA translocase FtsK"
FT /id="PRO_0000098251"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 188..765
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 435..626
FT /note="FtsK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT BINDING 455..460
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 765 AA; 84580 MW; 4987DDC4D2F2F6EA CRC64;
MVTIKINNNV HIILEVIYLP RNKQYKKNKQ DKISETTLNS DIAGISIFAF GAFAAVSMFF
TSFTGIIGNG MKKLLFTLVG IGAYIFPILL MFIGVCYLIK KGKITFSKRF YGVNIIIINT
LMLIQMQKLS LYYNGNILDG IKKIYESSDT FHGGVISYIL DVPIYKLFGK GYFVLFITLY
IISFLLVSEK SAGEIIRENL KKKPLKKTKP SVDETKTMDY ENDNKDKDET LAKKISSKIK
IVDFMKNEGN VDSNKGQALE EIAVYDSAEK NENESKVIGA ELEDAIGQTS SNNSDITYEF
PPISLLNVNE TSKLKKSDKK ELLSSAEKLT ETLNSFGVDA KVIQVSKGPS VTRYELQPSA
GVKVSKIINL SDDIALNLAA SGVRIEAPIP GKSAIGIEVP NKDLTAVFLS EVIQSETFSN
SKSNLAFALG KDIGGNCVVT DLTKMPHLLI AGATGSGKSV CINTLIISLL YKCAPTDVKL
LMIDPKVVEL SVYNGIPHLL IPVVTNPKKA AGALNWAVNE MTKRYKLFAE NNVRNIEGYN
DLYTKNKVES KLPWIVIIID ELADLMMVCP NDVEDYIGRL AQMARAAGMH LVIATQRPSV
DVITGVIKAN IPSRISFAVS SQIDSRTILD TSGAEKLLGK GDMLFNPVGE SKPIRIQGAF
INEEEVERVV GFIRNESTET QYKEEIIEQI NSNVSKSEGD EDELLEEALK IIIETKQAST
SLIQRKLRIG YNRAARIMDQ LEEKGYISAK DGTKPRNILV DKDDL
