ID   FTSK_HAEIN              Reviewed;         529 AA.
AC   P45264;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=DNA translocase FtsK;
GN   Name=ftsK; OrderedLocusNames=HI_1592;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: May function as a DNA motor that moves dsDNA in an ATP-
CC       dependent manner towards the dif recombination site, which is located
CC       within the replication terminus region. Translocation stops
CC       specifically at Xer-dif sites, where FtsK interacts with the Xer
CC       recombinase, allowing activation of chromosome unlinking by
CC       recombination. FtsK orienting polar sequences (KOPS) guide the
CC       direction of DNA translocation. FtsK can remove proteins from DNA as it
CC       translocates, but translocation stops specifically at XerCD-dif site,
CC       thereby preventing removal of XerC and XerD from dif (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homohexamer. Forms a ring that surrounds DNA (By similarity).
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: Although strongly related to FtsK, it lacks the typical
CC       transmembrane domains located at the N-terminal part of FtsK.
CC   -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family. {ECO:0000305}.
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DR   EMBL; L42023; AAC23240.1; -; Genomic_DNA.
DR   PIR; G64131; G64131.
DR   AlphaFoldDB; P45264; -.
DR   SMR; P45264; -.
DR   STRING; 71421.HI_1592; -.
DR   EnsemblBacteria; AAC23240; AAC23240; HI_1592.
DR   KEGG; hin:HI_1592; -.
DR   eggNOG; COG1674; Bacteria.
DR   HOGENOM; CLU_001981_9_10_6; -.
DR   OMA; YKAEARD; -.
DR   PhylomeDB; P45264; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR041027; FtsK_alpha.
DR   InterPro; IPR002543; FtsK_dom.
DR   InterPro; IPR018541; Ftsk_gamma.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF17854; FtsK_alpha; 1.
DR   Pfam; PF09397; FtsK_gamma; 1.
DR   Pfam; PF01580; FtsK_SpoIIIE; 1.
DR   SMART; SM00843; Ftsk_gamma; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50901; FTSK; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; Cell division; Chromosome partition; DNA-binding;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..529
FT                   /note="DNA translocase FtsK"
FT                   /id="PRO_0000098261"
FT   DOMAIN          174..387
FT                   /note="FtsK"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          509..529
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         194..199
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
SQ   SEQUENCE   529 AA;  58768 MW;  0C0F882EADFE726D CRC64;
     MEAVQLDKNQ EPNYKGYSGS LIHPAFQQQT TKREKPSTPL PSLDLLLKYP PNEQRITPDE
     IMETSQRIEQ QLRNFNVKAS VKDVLVGPVV TRYELELQPG VKASKVTSID TDLARALMFR
     SIRVAEVIPG KPYIGIETPN LHRQMVPLRD VLDSNEFRDS KATLPIALGK DISGKPVIVD
     LAKMPHLLVA GSTGSGKSVG VNTMILSLLY RVQPEDVKFI MIDPKVVELS VYNDIPHLLT
     PVVTDMKKAA NALRWCVDEM ERRYQLLSAL RVRNIEGFNE KIDEYEAMGM PVPNPIWRLG
     DTMDAMPPAL KKLSYIVVIV DEFADLMMVA GKQIEELIAR LAQKARAIGI HLILATQRPS
     VDVITGLIKA NIPSRIAFTV ASKIDSRTIL DQGGAEALLG RGDMLYSGQG SSDLIRVHGA
     YMSDDEVINI ADDWRARGKP DYIDGILESA DDEESSEKGI SSGGELDPLF DEVMDFVINT
     GTTSVSSIQR KFSVGFNRAA RIMDQMEEQG IVSPMQNGKR EILSHRPEY