FTSK_LISIN
ID FTSK_LISIN Reviewed; 762 AA.
AC Q92BW9;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=DNA translocase FtsK;
GN Name=ftsK; OrderedLocusNames=lin1423;
OS Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=272626;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-680 / CLIP 11262;
RX PubMed=11679669; DOI=10.1126/science.1063447;
RA Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT "Comparative genomics of Listeria species.";
RL Science 294:849-852(2001).
CC -!- FUNCTION: Essential cell division protein that coordinates cell
CC division and chromosome segregation. The N-terminus is involved in
CC assembly of the cell-division machinery. The C-terminus functions as a
CC DNA motor that moves dsDNA in an ATP-dependent manner towards the dif
CC recombination site, which is located within the replication terminus
CC region. Required for activation of the Xer recombinase, allowing
CC activation of chromosome unlinking by recombination (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homohexamer. Forms a ring that surrounds DNA (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Note=Located at the septum. {ECO:0000250}.
CC -!- DOMAIN: Consists of an N-terminal domain, which is sufficient for the
CC localization to the septal ring and is required for cell division,
CC followed by a linker domain, and a C-terminal domain, which forms the
CC translocation motor involved in chromosome segregation. The C-terminal
CC domain can be further subdivided into alpha, beta and gamma subdomains.
CC The alpha and beta subdomains form the DNA pump, and the gamma
CC subdomain is a regulatory subdomain (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family. {ECO:0000305}.
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DR EMBL; AL596168; CAC96654.1; -; Genomic_DNA.
DR PIR; AF1610; AF1610.
DR RefSeq; WP_010991527.1; NC_003212.1.
DR AlphaFoldDB; Q92BW9; -.
DR SMR; Q92BW9; -.
DR STRING; 272626.lin1423; -.
DR EnsemblBacteria; CAC96654; CAC96654; CAC96654.
DR KEGG; lin:lin1423; -.
DR eggNOG; COG1280; Bacteria.
DR eggNOG; COG1674; Bacteria.
DR HOGENOM; CLU_001981_9_6_9; -.
DR OMA; FGEWYML; -.
DR OrthoDB; 349533at2; -.
DR Proteomes; UP000002513; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell cycle; Cell division; Cell membrane;
KW Chromosome partition; DNA-binding; Membrane; Nucleotide-binding;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..762
FT /note="DNA translocase FtsK"
FT /id="PRO_0000098268"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..762
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 428..624
FT /note="FtsK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 448..453
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 762 AA; 84089 MW; FF6CF486E9F025A3 CRC64;
MATQKKKTAG RKKTSTRSKK KKSASFRLEI TGAVLIAIGI IGILQLGFVG RGFFALAEMF
VGLLSYVLLA GSIVLGGYMV IRRKMPHLFS KRLVGVYLIV LGFLTYIHMY FIIHNLGANA
PVVSSTWKLV LENLFRPNQV GFVGAGMIGA AITSVTYFLL DRLGTNIIAI LLIIYGFSLV
SGISVRQFFS KITEFVRYLF SKGKAAKEKG KEVKAKRDKK KAEKLVEVEA DEVIEVSQPI
DASKEEKTPP IISNFSSKVE QEKAPLEEKT ESDVKEKDLE MFQQESFENE IYQLPSVDIL
EPAKVTDQSK EYDQIKVNAK KLEDTFESFG VKAKITQVHL GPAVTKYEVQ PSVGVKVSKI
VSLSDDIALA LAAKDIRIEA PIPGKSAIGI EVANQNVAMV SLREVLENNP KNNPDEKLQI
ALGRDISGEA MMASLDKMPH LLVAGATGSG KSVCINGIIT SILLRAKPHE VKMMMIDPKM
VELNVYNGIP HLLAPVVTNP KKAAQALQKV VAEMERRYDL FSHTGTRNMQ GYNDYVKKHN
ELNEEKQPEL PFIVVIVDEL ADLMMVASND VEDAITRLAQ MARAAGIHLI IATQRPSVDV
ITGVIKANIP SRIAFAVSSS IDSRTILDMG GAEKLLGRGD MLLLPVGSSK PTRIQGAFLS
DKEVEDVVNY VISQQKAQYN EEMIPDDIPE VEGEVTDELY HEAVELVVEM QTASVSMLQR
KFRIGYNRAA RLIDEMEQRG VVGPHEGSKP RRVNVELPPD IE
